Nine compounds derivated from 2-mercaptobezothiazole were synthesized. Their structure have been identified by MS-, IR-, and UV- spectroscopy. Antimicrobial activities of some compounds have been tested. Hydrazide BT6 and substituted hydrazides BT7, BT8, BT9 were found to have significant inhibitory activity on P. aeruginosa, S. aureus, Asp. niger and F. oxysporum at concentration 50mcg/ml.
Pharmaceutical Preparations

Realtime xCELLigence analysis (RTCA) is a new cell detection technology to continuously monitor, record and analyze a variety of information generated by cell activity. In drug research, it plays an important role in assessing myocardial toxicity and cell biological activity. Here, we first introduce the underlying mechanisms and characteristics of RTCA. Then we review the applications of RTCA in the research of myocardial toxicity and cell biological activity, to provides the fundamental baseline for understanding and exploiting RTCA. With the real-time, unlabeled, non-invasive, high throughput, and high accuracy features, RTCA not only promotes drug research and development, but also has a broad and good application prospect in other fields.
Pharmaceutical Preparations

According to the results of an investigation on 270 households in May 1999 carried out in Tien Son district, Bac Ninh province, 56 (20.79%) purchasing households came to commune health centre, 195 (72.22%) came to private clinic, 8 (2.96%) came to public pharmacy and 11 (4.03%) came to private pharmacy. Quality of the drug, easiness to access, reasonable price, good counseling... are the favorable factors to promote the purchaser's choice
Pharmaceutical Preparations ; Pharmaceutical Services

The oral Bio-availability of two different capsule formulations of artmisinin was carried out in six rabbits divided in two groups and seven healthy male volunteers in a single-dose crossover design with randomization for dosing sequence. The experimental results showed that the relative bioavailability of the formulation, that was made of artemisinin solid dispersion system using Eudragit L100 as a carrier on ratio 1:1, was more two times higher than the modification of artemisinin capsules without any modifications. There was a good correlation between in vitro dissolution data obtained by dissolution test with the mean AUG values of each studied group after oral administration.
Artemisinine ; Pharmaceutical Preparations ; therapeutics

Achito compound was prepared by the grft-copolymerization of artesunate and chitosan. The dynamic of Achito hydrolytis process into artesunate and chitosan has been studied. The obtained results showed that: the artesunate content has been quickly released from polymeric carrier in the first hour, then it was slowly liberated in the following 24 hours. At the 24th hour 99% artesunate was released from the Achito. After 48 hours 100% artesunate was released.
Artesunate ; Pharmaceutical Preparations

Artesunate has been produced and used in Vietnam since 1993, but up to 1998, we only produced and used artesunate for tabletting. Since 1998 a research program of injectable artesunate was launched by Ministry of Health. We have succeeded in the production of artesunate powder for injection in two steps: -Producing high quality artesunate powder for injection from the high quality artesunate.
Artesunate ; Pharmaceutical Preparations

Artemisinin and its derivatives are nowadays among the most effective antimalarials. However, the relapse rate with artemisinin and related compounds is relatively high. In order to overcome this, some experimental formulations of prolonged release tablet of artesunat are tested. The chosen formulation met the following demands: after an effective loading concentration of the active compound, there is a steady release of maintenance dose during 8 hours.
Artesunate ; Pharmaceutical Preparations ; tablets

On basis of the chemical structure of artesunate, 4 identification tests were proposed. They were as follows: Artesunate reacts with a potassium iodide solution to form iodine; artesunate reacts with 5% potassium dichromate solution and 2% sulphuric acid to form acid perchromic; artesunate reacts with cupri-tar-taric solution R to form a red precipitate; artesunat reacts with silver nitrate solution R and dilute ammonia R1 to form a silver mirror. A new method for the determination of artesunate was proposed as alkalimetric titration. The validation of the method was carried out and the results showed that the method was precise, linear, accurate and more specific than the current method.
Artesunate ; Pharmaceutical Preparations

Two current methods for assay of artesunate in our country have been validated and they meet the criteria for accuracy and precision; but do not meet criterion for specificity. Impurities in artesunate interfere with determinations. Result of artesunate determination according to quality specifications in-house increased 5.6% when 1% of succinic acid was presented in the sample to be assayed. If artesunate was assayed according to official quality specifications, result of the determination increased 1.4% when 1% of DHA is presented in the sample to be determined.
Methods ; artesunate ; Pharmaceutical Preparations

A survey on 120 consumers who have been treated by traditional medicine in Hanoi. Results of the study showed that the average age of them is 48.8, the main of the consumers have gastrointestinal tract diseases, rheumatics, cough and flu with 16.7%, 24.2%, 23.3% respectively. The average cost of a treatment course by traditional medicine is about 7.5 USD, it is not reasonable price for people with low earning. The belief of the consumers in traditional remedies are more and more increasing. Most of them think that the traditional medicine have no poisoning and adverse drug reactions
Medicine, Traditional ; Pharmaceutical Preparations