Nine compounds derivated from 2-mercaptobezothiazole were synthesized. Their structure have been identified by MS-, IR-, and UV- spectroscopy. Antimicrobial activities of some compounds have been tested. Hydrazide BT6 and substituted hydrazides BT7, BT8, BT9 were found to have significant inhibitory activity on P. aeruginosa, S. aureus, Asp. niger and F. oxysporum at concentration 50mcg/ml.
Pharmaceutical Preparations

Realtime xCELLigence analysis (RTCA) is a new cell detection technology to continuously monitor, record and analyze a variety of information generated by cell activity. In drug research, it plays an important role in assessing myocardial toxicity and cell biological activity. Here, we first introduce the underlying mechanisms and characteristics of RTCA. Then we review the applications of RTCA in the research of myocardial toxicity and cell biological activity, to provides the fundamental baseline for understanding and exploiting RTCA. With the real-time, unlabeled, non-invasive, high throughput, and high accuracy features, RTCA not only promotes drug research and development, but also has a broad and good application prospect in other fields.
Pharmaceutical Preparations

According to the results of an investigation on 270 households in May 1999 carried out in Tien Son district, Bac Ninh province, 56 (20.79%) purchasing households came to commune health centre, 195 (72.22%) came to private clinic, 8 (2.96%) came to public pharmacy and 11 (4.03%) came to private pharmacy. Quality of the drug, easiness to access, reasonable price, good counseling... are the favorable factors to promote the purchaser's choice
Pharmaceutical Preparations ; Pharmaceutical Services

Quality of the locally produced artesunate 50mg tablets provided by the National Malaria Control program to five provinces of Cao Bang, Bac Kan, Ha Tinh and Ninh Thuan was monitored in a survey from June 2001 to December 2004 that was conformed with the expiry date of the drug. The drug had also been previously found to meet the quality criteria of manufacturer and pharmacopoeia. Analysis of samples collected from five provinces showed a remaining stable quality of mass equability, disintegration, hardness and solubility as permitted limits. The artesunate concentration was found to be 90-100% and 95-105% according to pharmaceutical classes and manufacturer criteria, respectively
Malaria ; Pharmaceutical Preparations ; Artemisinins

To establish an appropriate hospital drug list, the local disease prevalence and the revision of drug treatment in Khanh Hoa Rehabilitation Nursing Hospital, a survey and statistics were taken in 9 years (1995-2003). The disease categories observed in the hospital were contained in 19 chapters of The International Classification of Diseases and Related Health Problems - 10th revision (ICD10). Three chapters associated with high prevalence are chapter VI (Diseases of the nervous system), chapter IX (Diseases of the circulation system), and chapter XIII (Diseases of the musculoskeletal system and connective tissue). Based on the local disease prevalence observed in the hospital, treatment guidelines, management capability and payment ability of patients, the Multi-Attribute Decision Analysis Method (MADAM) was applied to list available drugs used in Khanh Hoa Rehabilitation Nursing Hospital. Five decision evaluation criteria including efficacy, safety, ease of use, cost of drug and origin of drug were weighted and scored for the choice of drugs. The obtained result was a drug list which almost uses and promotes the 4th Essential Drug Concept
Pharmaceutical Preparations ; Therapeutics

The content of diosgenine in some species of dioscorea branch is determined by gas chromatography. This method is convenient and high confidence. Some species contain substantial diosgenine for production. This method can be applied for controlling the material in production.
Pharmaceutical Preparations ; Chromatography, Gas

Some algorithms used in UV-Vis MCA spectrophotometry technique and some recent statistical approaches to the Advanced MCA technique were described. A number of pharmaceutical formulas containing 2-4 ingredients has been analyzed successfully using MCA technique. Basing on the basic algorithm of MCA and its statistical approaches, an applicable software for data processing had been established (running in Windows (environment - IBM compatible computer). This enables to use MCA technique for conventional spectrophotometers.
Pharmaceutical Preparations ; prevention & control

A survey has been carried out at 36 communes from 9 provinces represented for the whole country from January to March 1996 in order to evaluate the drug sale, the drug management in commune health stations and in private pharmacies. The results indicate that there are also many limitations and weaknesses in performance of certain regulations of MOH. The authors have proposed some procedures to improve these limitations.
Pharmaceutical Preparations ; Residence Characteristics

A quality of domestic drugs is not high, which is not enough capacity to compete with market of Vietnam and difficult integrated to market of other countries. It should strengthen to guarantee of drug quality, supply and price for people
Pharmaceutical Preparations ; Quality Control

Purpose: find out synthesis of carbutamine. Experiment: from acetanilid through 5 steps: (1) Preparing acetamidobenzen sulfoclorua; (2) Preparing p-acetamindobenzensulfonamid; (3) Preparing p-acetamidobenzen sulfonylure; (4) Preparing N1-nbutyl, N2-su;lanilylure. (5) Product completely resemble carbutamid, which extracted refinement from bucarban tablet of Hungary, as infra-red spectrum and sensitivity.
Pharmaceutical Preparations ; Hypoglycemic Agents