Nine compounds derivated from 2-mercaptobezothiazole were synthesized. Their structure have been identified by MS-, IR-, and UV- spectroscopy. Antimicrobial activities of some compounds have been tested. Hydrazide BT6 and substituted hydrazides BT7, BT8, BT9 were found to have significant inhibitory activity on P. aeruginosa, S. aureus, Asp. niger and F. oxysporum at concentration 50mcg/ml.
Pharmaceutical Preparations

Realtime xCELLigence analysis (RTCA) is a new cell detection technology to continuously monitor, record and analyze a variety of information generated by cell activity. In drug research, it plays an important role in assessing myocardial toxicity and cell biological activity. Here, we first introduce the underlying mechanisms and characteristics of RTCA. Then we review the applications of RTCA in the research of myocardial toxicity and cell biological activity, to provides the fundamental baseline for understanding and exploiting RTCA. With the real-time, unlabeled, non-invasive, high throughput, and high accuracy features, RTCA not only promotes drug research and development, but also has a broad and good application prospect in other fields.
Pharmaceutical Preparations

According to the results of an investigation on 270 households in May 1999 carried out in Tien Son district, Bac Ninh province, 56 (20.79%) purchasing households came to commune health centre, 195 (72.22%) came to private clinic, 8 (2.96%) came to public pharmacy and 11 (4.03%) came to private pharmacy. Quality of the drug, easiness to access, reasonable price, good counseling... are the favorable factors to promote the purchaser's choice
Pharmaceutical Preparations ; Pharmaceutical Services

Our study included 14 patients admitted to Bachmai hospital because of headache and hypertension after taking anti-cold preparations (Rhumenol Decolgen, Decolsin, and Medicoldac) from 3/2002 to 6/2002. These patients had no history of hypertension and took antiflu tablets according to instruction of manufacturers. On admission, all patients had hypertension with the maximum BP 190/120mmHg. The first-degree atrioventricular block was observed in 1 case. The adverse effects may be caused by overdose of phenylpropanolamine, a sympathomimetic agent. Our study is a warning of dangerous reality of broadly advertising, marketing and abusing drugs. The manufacturers should consider the amount of Phenylpropanolamine in anti-cold preparations to avoid the adverse effect.
Pharmaceutical Preparations ; Adverse effects

The study was carried out in 36 grown-up rabbits with average weight 2±0,3kg. The results showed that: skin tissue exposed to oxidant was severe injury with necrosis area into muscle, bone and healing process was slow. Skin injury caused by burn substance was milder: main characteristics of skin lesions were congestion and edema, healing process is faster. Treatment of the skin lesions: spraying water on the contaminated area of the skin and application of B76 everyday was effective. Healing image of the skin tissue appeared early and fast.
Skin ; Pharmaceutical Preparations

The azometine derivatives of 5 nitrofurfural remain the biological activities of azometine beside of 5-nitrofurfural actives. Obtained 6 compounds which are crystals with certain melting point and content of elements as estimated formulation have anti fungal and anti microbial activities.
analogs & derivatives ; Pharmaceutical Preparations

Angelica sinensis Diels have of blood tonic, laxative effects and was used for irregular period, pain in bones and joins, and dry and weak stomach and loss appetite. This herb can be an alternative for blood tonic medication, so it should not be used concomitantly with vitamins and should be prescribed based on causes of diseases
Pharmaceutical Preparations ; Angelica sinensis

Species Da cam was identified as being Hedyotis capitellata Wall. Ex G.Don var. molis Piere ex Pit. It is used as a drug in traditional medicine. Primary results on our studies of Da cam have been presented that: the of Da cam contained alkaloid, saponin, iridoid, tanin. We have extracted and isolated from the leaves caulis of Da cam Sapogenin KLD3 and determinated it was Olanaolic acid
chemistry ; Hedyotis ; Pharmaceutical Preparations

The oral Bio-availability of two different capsule formulations of artmisinin was carried out in six rabbits divided in two groups and seven healthy male volunteers in a single-dose crossover design with randomization for dosing sequence. The experimental results showed that the relative bioavailability of the formulation, that was made of artemisinin solid dispersion system using Eudragit L100 as a carrier on ratio 1:1, was more two times higher than the modification of artemisinin capsules without any modifications. There was a good correlation between in vitro dissolution data obtained by dissolution test with the mean AUG values of each studied group after oral administration.
Artemisinine ; Pharmaceutical Preparations ; therapeutics

Achito compound was prepared by the grft-copolymerization of artesunate and chitosan. The dynamic of Achito hydrolytis process into artesunate and chitosan has been studied. The obtained results showed that: the artesunate content has been quickly released from polymeric carrier in the first hour, then it was slowly liberated in the following 24 hours. At the 24th hour 99% artesunate was released from the Achito. After 48 hours 100% artesunate was released.
Artesunate ; Pharmaceutical Preparations