1.Anticonvulsant hypersensitivity syndrome secondary to lamotrigine mimicking a septic episode.
Deborah J E MARRIOTT ; Petrick PERIYASAMY
Annals of the Academy of Medicine, Singapore 2011;40(9):422-423
Animals
;
Anticonvulsants
;
adverse effects
;
Cattle
;
Drug Hypersensitivity
;
complications
;
diagnosis
;
etiology
;
Female
;
Humans
;
Lupus Erythematosus, Systemic
;
complications
;
Middle Aged
;
Sepsis
;
diagnosis
;
Syndrome
;
Triazines
;
adverse effects
;
Zoonoses
;
etiology
4.Salmonella related mycotic aneurysm with psoas and paraortic abscess treated conservatively.
Azlina Abu BAKAR ; C S NGIU ; M S Mohamad SAID ; Petrick PERIYASAMY
Annals of the Academy of Medicine, Singapore 2011;40(10):467-468
Aneurysm, Infected
;
etiology
;
microbiology
;
physiopathology
;
Aorta, Abdominal
;
diagnostic imaging
;
physiopathology
;
Comorbidity
;
Female
;
Humans
;
Psoas Abscess
;
etiology
;
microbiology
;
physiopathology
;
Psoas Muscles
;
diagnostic imaging
;
physiopathology
;
Radiography
;
Salmonella
;
isolation & purification
;
Salmonella Infections
;
complications
5.Pharmacotherapeutics in the Critically Ill COVID-19 Patients
Wan Rahiza Wan Mat ; Cheah Saw Kian ; Aliza Mohamad Yusof ; Lau Chee Lan ; Michelle Tan Hwee Peng ; Petrick Periyasamy
Malaysian Journal of Medicine and Health Sciences 2022;18(No.1):316-323
Pharmacotherapeutics are being repurposed and used as off-label at various stages of COVID-19 infection. Clinical
trials are being initiated or are ongoing to investigate the effectiveness and safety of these pharmacotherapeutics. This
review article outlines the current pharmacotherapeutics and the controversies surrounding their use. The pharmacotherapeutics that were discussed are hydroxychloroquine, favipiravir, lopinavir/ritonavir, remdesivir, interferons,
tocilizumab, and steroids. We also discussed the special consideration for pharmacotherapeutics in COVID-19
infection. No pharmacotherapeutics have been found to be effective and approved for the treatment of COVID-19
infection. However, there are clinical trials that have eliminated the possibilities of use of some pharmacotherapeutics while others had shown promising preliminary results of its use
6.Emergence Of Dengue Virus Type 4 During COVID-19 Pandemic In Patients Admitted to a Teaching Hospital In Malaysia (Peningkatan virus denggi serotip keempat semasa pandemik COVID-19 pada pesakit yang dimasukkan ke hospital pengajar di Malaysia)
Mahrunissa Mahadi ; Siti Norlia Othman ; Najma Kori ; Sharifah Azura Salleh ; Zetti Zainol Rashid ; Petrick Periyasamy ; Nor Azila Muhammad Azami ; Noraidatulakma Abdullah ; Hui-min Neoh
Malaysian Journal of Health Sciences 2023;21(No.1):115-125
Prior to COVID-19, dengue was an important public health problem in Malaysia. Due to the movement control order
imposed by the Malaysian government to curb the COVID-19 transmission, a study predicted that mosquito-borne
diseases would increase during lockdown and partial lockdown seasons. Thus, this study aims to determine the current
situation of dengue incidence during the pre-COVID-19 pandemic (2019) and during the COVID-19 pandemic (2020
and 2021). We compared the number of laboratory-confirmed cases in the pre-COVID19 year (2019) and during the
COVID-19 pandemic (2020 and 2021). In addition to that, we characterized the clinical manifestation, dengue serotype
and viremia levels of dengue patients that were admitted to the Hospital Cancelor Tuanku Muhriz. We found a significant
decrease in the number of laboratory-confirmed cases between COVID-19 pandemic and the pre-covid period
(p2020=0.064; p2021<0.001). In this study, we found DENV 4 serotype was the most common serotype in dengue
patients admitted to our hospital. There was no significant correlation between DENV serotype/viremia level with
clinical manifestation of dengue fever and dengue with warning signs. However, patients infected with DENV4 had the
highest viral load compared to patients infected with other serotypes. We also found high viremia levels were significantly
associated with the febrile phase.
7.Lung computed tomography patterns of a cluster of asymptomatic young males with COVID-19 admitted to a teaching hospital in Kuala Lumpur
Boon Hau Ng ; Nik Nuratiqah Nik Abeed ; Andrea Ban Yu Lin ; Mohamed Faisal Abdul Hamid ; Lydia Kamaruzaman ; Muhammad Yusuf Abu Shamsi ; Halim Gafor ; Norlaila Mustafa, ; Wan Nur Nafisah Wan Yahya ; Shahrul Azmin ; Khoo Ching Soong ; Hemalatha Munusamy ; Zhen Hao Ching ; Hsueh Jing Low ; Petrick Periyasamy
The Medical Journal of Malaysia 2020;75(4):368-371
Background and objective: Coronavirus Disease 2019 (COVID19) was first reported in Malaysia in March 2020. We describe
here the clinical characteristics and computed tomography
(CT) patterns in asymptomatic young patients who had
laboratory-confirmed COVID-19.
Methods: This is a retrospective observational study where 25
male in-patients with laboratory-confirmed COVID-19 in
Hospital Canselor Tuanku Muhriz. Demographics, clinical
data and CT images of these patients were reviewed by 2 senior
radiologists.
Results: In total there were 25 patients (all males; mean age
[±SD], 21.64±2.40 years; range, 18-27 years). Patients with
abnormal chest CT showed a relatively low normal absolute
lymphocytes count (median: 2.2 x 109/L) and absolute
monocyte count (median: 0.5 x 109/L). Lactate dehydrogenase
was elevated in 5 (20%) of the patients. The procalcitonin level
was normal while elevated levels of alanine aminotransferase,
total bilirubin, platelet and C-reactive protein were common.
Baseline chest CT showed abnormalities in 6 patients. The
distribution of the lesions were; upper lobe 3 (12%) lower lobe
3 (12%) with peripheral distribution 4 (16%). Of the 25
patients included, 4 (16%) had ground glass opacification
(GGO), 1 (4%) had a small peripheral subpleural nodule, and
1 (4%) had a dense solitary granuloma. Four patients had
typical CT features of COVID-19.
Conclusion: We found that the CT imaging showed peripheral
GGO in our patients. They remained clinically stable with no
deterioration of their respiratory symptoms suggesting stability
in lung involvement. We postulate that rapid changes in CT
imaging may not be present in young, asymptomatic,
non-smoking COVID-19 patients. Thus the use of CT thorax
for early diagnosis may be reserved for patients in the older age
groups, and not in younger patients.
8.A descriptive study of the psychological experience of health care workers in close contact with a person with COVID-19
Boon Hau Ng ; Nik Nuratiqah Nik Abeed ; Mohamed Faisal Abdul Hamid ; Chun Ian Soo ; Hsueh Jing Low ; Najma Kori ; Petrick Periyasamy ; Norlaila Mustafa ; Andrea Ban Yu-Lin
The Medical Journal of Malaysia 2020;75(5):485-489
Background: COVID-19 has the potential to affect the mental
health of health care workers (HCWs). It is known that HCWs
who serve as front-liners during the COVID-19 pandemic
experience stress and have the fear of contracting the
infection. Little is known of how being a positive contact
affects HCWs. Objective: We examined the experience of
HCWs who were quarantined following a close unprotected
contact with a COVID-19 positive colleague and explore the
psychological impact especially as the timing of the
quarantine coincided with the Eid (annual Muslim festival)
celebration in Malaysia.
Methods: This was a cross-sectional on-line questionnaire
study, involving HCWs exposed to a COVID-19 positive
colleague in Universiti Kebangsaan Malaysia Medical
Centre, a teaching hospital. Data on demographics, levels of
depression, anxiety and stress using a validated
depression, anxiety, and stress scale (DASS-21)
questionnaire, aspects of quarantine, wearing of masks,
hand hygiene practice and swab experience were collected.
Results: Twenty-two HCWs participated. Eighteen (81.8%)
were between 30-39 years and 17 (77.3%) were women.
Majority 19 (86.3%) were Malays. There were twelve (54.5%)
medical officers, 5 (22.7%) specialists and 5(22.7%) allied
health staff. Eighteen out of 22 (81.8%) felt they were able to
do home quarantine adequately. All tested negative with a
mean (Standard Deviation) hour of contact of 2.56±2.38
hours. Eighteen reported their biggest concern was
infecting their families.
Conclusion: HCWs undergoing contact swabbing and
quarantine are vulnerable to depression, anxiety and stress.
The ability of the HCW to adequately home quarantine
should not be taken for granted. Psychological support
should be offered to HCWs who are positive contacts.
9.COVID-19 detected from targeted contact tracing, attempting to see the pattern in random happenings: early lessons in Malaysia
Boon Hau Ng ; Andrea Ban Yu-Lin ; Nik Nuratiqah Nik Abeed ; Mohamed Faisal Abdul Hamid, ; Chun Ian Soo ; Najma Kori ; Petrick Periyasamy,
The Medical Journal of Malaysia 2020;75(5):582-584
The world feels strange as we face what is for most of us ourfirst ever pandemic. The number of newly diagnosed casesrises daily in many parts of the world, and we are faced withthe reality that there are still many things to learn about thisnew disease. We share here our experience of treating ourfirst 199 COVID-19 patients in the Hospital Canselor TuankuMuhriz, Pusat Perubatan Universiti Kebangsaan Malaysia(PPUKM).