OBJECTIVE To understand the disinfection,use and management of ventilator for the sake of regulation.METHODS By interviewing and on-site survey,we understanded the method and the process of disinfection and found out the using cycle of the ventilator system and the conditions of its management.RESULTS Among 44 ventilators 7 models were found:the management of 18 ventilators was irregular;the other 26 ventilators were disinfected by 2 kind and 4 types disinfect methods.their using cycles were unsure,their processes of disinfection were irregular.The responsibilities for the disinfection were unclear,lacking of monitoring the effect of disinfection and their management was irregular.CONCLUSIONS The disinfection of ventilator using and management must be regulated.

Objective To observe the clinical effect ofTongfu-Xiefei decoction for the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with phlegm-heat syndrome.Methods A total of 78 AECOPD patients were selected from June 2015 to December 2016 in the respiratory department of our hospital, and the patients were randomly divided into two groups according to the random number table method, 39 patients in each group. The control group was treated with convertional western medicine and placebo decoction. Treatment group was treated with convertional western medicine and true decoction. Both groups were treated for 2 weeks and fellowed up for 4 weeks. The symptoms score, SGRQ scores, blood gas analysis were observed and analyzed. The clinical curative effect and adverse evevts were observed.Results After treatment, the symptom cough (2.34 ± 1.11vs. 2.67±1.05,t=2.277), expectoration (1.91 ± 1.41vs. 2.35 ± 1.83, t=2.106), asthmoid (1.73 ± 1.15vs. 2.04 ± 1.53,t=2.214) scores in the treatment group were significantly lower than the control group (P<0.05). The SGRQ scores (42.47 ± 17.24vs. 59.95 ± 17.58,t=2.112) in the treatment group was significantly lower than the control group (P<0.05). The total effective rate in the treatment group was 91.9% (34/37) and 84.4% in the control group (27/32). The difference between the 2 groups was statistically significant (χ2=4.578,P=0.040).Conclusions TheTongfu-Xiefei decoction can effectively alleviate the symptoms and signs, improve the blood gas analysis index, and the long-term curative effect for AECOPD patients with phlegm-heat syndrome.

Various c-mesenchymal-to-epithelial transition (c-MET) inhibitors are effective in the treatment of non-small cell lung cancer; however, the inevitable drug resistance remains a challenge, limiting their clinical efficacy. Therefore, novel strategies targeting c-MET are urgently required. Herein, through rational structure optimization, we obtained novel exceptionally potent and orally active c-MET proteolysis targeting chimeras (PROTACs) namely D10 and D15 based on thalidomide and tepotinib. D10 and D15 inhibited cell growth with low nanomolar IC₅₀ values and achieved picomolar DC₅₀ values and >99% of maximum degradation (D_max) in EBC-1 and Hs746T cells. Mechanistically, D10 and D15 dramatically induced cell apoptosis, G1 cell cycle arrest and inhibited cell migration and invasion. Notably, intraperitoneal administration of D10 and D15 significantly inhibited tumor growth in the EBC-1 xenograft model and oral administration of D15 induced approximately complete tumor suppression in the Hs746T xenograft model with well-tolerated dose-schedules. Furthermore, D10 and D15 exerted significant anti-tumor effect in cells with c-MET^Y1230H and c-MET^D1228N mutations, which are resistant to tepotinib in clinic. These findings demonstrated that D10 and D15 could serve as candidates for the treatment of tumors with MET alterations.