Objective To observe the effect of Chuanxiongqin injection combined with nimodipine on primary open angle glaucoma.Methods 112 patients with primary open angle glaucoma in ophthalmology department were grouped two groups,each with 56 cases.Two groups were treated with nimodipine and observation group was treated another with Chuanxiongqin injection to observe effect.Results After treatment,retinal light sensitivity,visual field defect,blood flow,blood flow velocity,erythrocyte migration rate,PSV,EDV and RI in central retinal artery of observation group were better than control group(P<0.05).There was no significant difference in adverse reactions between groups.Conclusion Chuanxiongqin injection can improve blood flow status of central retinal artery and optic papillary laminar, retinal light sensitivity and visual field defect for patients with primary open angle glaucoma.