1.Progress of biological characteristics and clinical signifiance of common heart failure markers
Clinical Medicine of China 2017;33(6):539-543
Heart failure is a serious and terminal stage of various cardiovascular diseases,is one of the most important heart diseases,and it also the most common reason for hospitalization.In recent years,studies on new markers in the diagnosis,treatment and prognosis of heart failure have made great progress,such as B-type brain natriuretic peptide can partially reflect hemodynamic imbalance,troponin can indicate cardiomyocyte injury,soluble ST2 and galectin-3 indicate myocardium remodeling and fibrosis,C-reactive protein,cystatin C and procalcitonin,and copeptin have significant prognostic value for outcomes,microRNA in the regulation of gene expression influence heart failure.
2.Research progress of risk factors for cardiovascular diseases
Chinese Journal of cardiovascular Rehabilitation Medicine 2015;24(1):98-101
Multiple risk factors lead to occurrence of cardiovascular diseases in common.Besides confirmed tradition-al risk factors,such as diabetes mellitus,dyslipidemia,smoking and hypertension etc.,some new risk factors have been found in recent years.The confirmed risk factors need further research,while the new risk factors need en-hanced study.
3.Mechanism of radiofrequency ablation in treatment of hepatocellular carcinoma
Journal of Clinical Hepatology 2017;33(2):359-363
Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence and mortality rates around the world.Radiofrequency ablation (RFA) is an effective therapy for HCC,especially in patients who experience recurrence after surgery for liver cancer,who are complicated by liver dysfunction and unable to undergo surgical resection,and who have multiple liver tumors and undergo palliative treatment.RFA can significantly improve patients' survival time and quality of life.This article reviews the mechanism of RFA in the treatment of HCC from the aspects of direct and indirect injuries and helps to further understand the role of RFA in local and systemic treatment of HCC,which has a potential value for multidisciplinary treatment of HCC in future.
4.Bacterial Endotoxin Test for Shengmai Injection
Journal of Guangzhou University of Traditional Chinese Medicine 2000;0(04):-
Preliminary screening test and interfering test were used to study the bacterial endotoxin test (BET) for Shengmai Injection (SI). The results showed that there is no interference when the SI is diluted by 10 times and limulus reagent with a sensibility of 0.25EU/mL is used for BET.
5.Microvideo in college and university libraries in era of new media
Chinese Journal of Medical Library and Information Science 2017;26(6):67-70
After a description of the concept of microvideo and studies on microvideo in domestic college and university libraries,microvideo in domestic college and university libraries was investigated and the production of microvideo was elaborated with Jining Medical College as an example.Strategies for the solution of problems in microvideo were put forward for its popularization.
6.Anti-obesity effect of 11β -HSD1 inhibitor equisetin on ob/ob mice
Acta Pharmaceutica Sinica 2022;57(8):2399-2404
Equisetin (EQST) belongs to polyketide (PKS)-nonribosomal peptide synthetase (NRPS) type compound with an inhibitory effect of 11
7.Influence of inhibiting p38MAPK expression on TNF-α expression and myocardial cell apoptosis in rats with ischemia/reperfusion injury
Yongguo LIU ; Peng REN ; Guoqing LI
Chinese Journal of cardiovascular Rehabilitation Medicine 2013;22(6):538-542
Objective: To explore influence of p38 mitogen-activated protein kinase (p38MAPK) inhibitor on myocardial cell apoptosis and expression of tumor necrosis factor (TNF)-α in rats with ischemia/reperfusion (I/R) injury. Methods: According to number table method, a total of 30 SD rats were randomly and equally divided into blank control group, I/R group and inhibitor group. p38MAPK mRNA expression, TNF-α level and myocardial cell apoptotic rate were measured, compared and analyzed among three groups. Results: Compared with blank control group, there were significant increase in TNF-α level [(3.68±0.16) μg/L vs. (5.02±0.09) μg/L], p38MAPK mRNA expression [(1.76±0.46) vs. (2.35±0.02)] and myocardial cell apoptotic rate [-(3.51±0.40) % vs. - (1.8±0.23) %] in I/R group, P=0.001 all. Compared with I/R group, there were significant decrease in p38MAPK mRNA expression (2.09±0.16), TNF-α level [(4.15±0.11) μg/L] and myocardial cell apoptotic rate [-(2.9±0.50) %] in inhibitor group, P=0.001 all. Conclusion: Inhibition of p38 mitogen-activated protein kinase expression in myocardium of rats can decrease production of tumor necrosis factor-α and myocardial cell apoptosis, then relieve ischemia/ reperfusion injury of myocardial cells.
8.Research progress on pharmacogenomics of antiretroviral drugs
Chinese Pharmacological Bulletin 2014;(7):889-892,893
AIDS has become a global disease,and a variety of drugs are used in the treatment of AIDS ,but the interindividual variabilities in efficacy and toxicity remain important limitations for the use of these drugs.Studies have shown genetic polymor-phism is the main reason for interindividual variabilities of drug reaction.In recent years,scholars focused on the pharmacog-enomics of anti-AIDS drugs and found that genetic polymor-phisms,in large part,determine the interindividual variabilities of the responese of these drugs.This paper reviews the research progress on pharmacogenomics of the four types of anti-AIDS drugs commonly used in China,including nucleoside reverse transcriptase inhibitors (NRTIs),non-nucleoside reverse tran-scriptase inhibitors (NNRTIs),protease inhibitors (PIs)and integrase inhibitors (raltegravir).
9.Application of integrating 64-slice CT image and the CARTO system in catheter ablation of atrial fibrillation
Guoqing LI ; Juan YAO ; Peng REN
Chinese Journal of Interventional Cardiology 1996;0(04):-
Objective To explore the application of integrating 64-slice CT image with three-dimensional electroanatomic mapping(Carto-Merge) in guiding catheter ablation of atrial fibrillation(AF).Methods Fifteen patients with drug-refractory AF received catheter ablation of AF.64-slice CT scan was performee 1-3 days prior to the ablation procedures.Using a novel software package,the left atrium(LA)with PVs was segmented and extracted for image registration with a combination of landmark registration and surface registration.Results The integration of the CT image into the electroanatomic mapping system was performed successfully in all patients with an error of 2.11?0.82 mm.Thirty pairs of PVs were electrically isolated after circumferential rediogrequency pulmorary rein ablation.The mean procedure time was 170.51?38.47 minutes.Cardiac tamponade occurred in one patient.All the fifteen patients were free of AF recurrence after 3 months of follow up including the 2 cases of persistent AF who required antiarrhythmic drugs.No thromboembolic events or stenosis were observed.Conclusion Integration of 64-slice CT image into the CARTO system successfully performed in patients undergoing catheter ablation of AF and enhance the ablation success rate.
10.Assessment value of heart rate variability for cardiac autonomic nervous function in patients with acute stroke
Shikang ZHENG ; Hui REN ; Peng ZHU
Chinese Journal of cardiovascular Rehabilitation Medicine 2017;26(3):242-245
Objective: To explore assessment value of heart rate variability (HRV) of Holter for cardiac autonomic nervous function in patients with acute stroke.Methods: A total of 80 cases with acute stroke treated in our hospital were regarded as stroke group, and another 80 inpatients without cardio-and cerebrovascular diseases were enrolled as control group simultaneously.Holter was used to perform 24h ambulatory heart rate monitoring on two groups, and the results were compared between two groups.Results: Compared with control group, there were significant reductions in standard deviation of normal to normal RR intervals calculated over the 24 h period [SDNN, (129.89±5.42) ms vs.(92.58±4.36) ms], standard deviation of normal to normal RR intervals in all 5 min segments of the entire recording [SDANN, (118.85±5.79) ms vs.(77.36±4.82) ms], root-mean square of differences between successive normal to normal intervals [rMSSD, (27.04±1.18) ms vs.(7.31±1.09) ms] and adjacent normal RR interval difference >50ms stroke accounted for a percentage of 24h total RR interval [PNN50, (8.97±1.48)% vs.(2.62±0.54)%] in stroke group, P<0.01 all;in stroke patients, there were no significant difference in above indexes between cerebral infarction patients and cerebral hemorrhage patients, P>0.05 all.Conclusion: HRV indexes possess significant assessment value for cardiac autonomic nervous function in patients with acute stroke.They can predict patient′s status changes, and help to prevent and identify severe cerebrovascular disease in time.