1.Expression of Th17-related transcription factor RORγt mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus
Chinese Journal of Dermatology 2012;45(5):366-367
ObjectiveTo investigate the action mechanism of Th17 cells in immunoinflammatory response in systemic lupus erythematosus(SLE).MethodsReverse-transcription PCR was performed to measure the mRNA expre ssion of the retinoic acid receptor-related orphan nuclear receptor RORγt in peripheral blood mononuclear cells (PBMCs) from 12 patients with active SLE,9 patients with inactive SLE and 12 normal human controls.Data were statistically analyzed by approximate F test(Welch test) and Dunnett's T3 multiple comparison test (corrected).ResultsIn the case of RORγt mRNA expression in PBMCs,significant differences existed among the 3 groups(F =23.286,P < 0.01 ); in detail,the patients with active SLE were significantly higher than patients with inactive SLE and normal controls ( 1.06 ± 0.44 vs.0.65 ± 0.25,F =2.453,P < 0.05;1.06 ± 0.44 vs.0.22 ± 0.08,F =6.504,P < 0.05),and the patients with inactive SLE were significantly increased compared with the normal controls (F =3.343,P < 0.05).The expression level of RORγt mRN A was significantly positively correlated with SLE disease activity index (rp =0.623,P < 0.01 ).ConclusionsThere is a polarization of Th17 cells in patients with SLE.To antagonize the transcription factor RORγt,which plays an essential role in the regulation of Th17 cell differentiation,may facilitate the control of SLE via attenuating the immunoinflammatory response.
2.Clinical Observation of 50 Cases of Intracranial Infection after Neurosurgery
Hongwei GUO ; Peng BAI ; Xiao BAI
Journal of Kunming Medical University 2016;37(7):114-116
Objective To explore the clinical therapeutic effects of postoperative intracranial infection in neurosurgery.Methods Between January 2014 and January 2014,50 patients with postoperative intracranial infection in the department of neurosurgery in our hospital were selected in this study.Among the 50 patients,25 patients were treated by intravenous antibiotic therapy,15 patients were treated with intrathecal and intravenous antibiotics treatment,10 cases were treated by intrathecal injection,intravenous antibiotics and lumbar pool catheter drainage way for treatment,and then we observed the clinical therapeutic effect of three groups of patients.Results In 50 patients,37 patients were cured,3 cases had marked effect,8 patients had effect,2 patients had no effect.Conclusion For patients with neurosurgical operations,to maximally reduce the risk of intracranial infection,it is necessary to take antibiotics according to the actual situation of patients,and make different treatment schemes according to the difference of infection.
3.The analysis of the curative effect for the lipitor in curing essential hypercholesterolemia
Bai-Ru XIE ; Peng GAO ;
Chinese Journal of Primary Medicine and Pharmacy 2006;0(08):-
Objective To evaluate the curative effect of the atorvastatin calcium tablet(trade name:lipitor) in curing essential hypercholesterolemia.Methods 76 patients with essential hypercholesterolemia were divided into two groups randomly:43 patients in the research group(lipitor tablet 10mg,qn);33 patients in the comparison group (simvastatin tablet 20mg,qn).The period of treatment for both two groups was 6 weeks.The changes of blood fat were detected before and after taking the medicine.The curative effect were compared at the same time.Resnlts The total cholesterol(TC)of the research groups decreased by 37.06%,the TC of the comparison group decreased by 22.05%.The triacylglyceride(TG)of the research group decreased by 24.81%,however,the TG of the compar- ison group decreased by just 14.49%.The low-density lipoprotein cholesterol(LDL-C)of the research group de- creased by 42.30% while the comparison group just decreased by 28.30%(P<0,01).Also,the high-density lipoprotein cholesterol(HDL-C)of the research group increased by 7.80%,and the comparison group increased by 7.13%(P>0.05),The effective rate of the research group was 95.35%.For the comparison group,the effective rate was 90.91%.Conclusion The lipitor has a good curative effect in curing essential hypereholesterolemia.Also, the lipitor has fewer side effect,This medicine is safe and reliable for patients.
4.Resection procedure for pancreatic carcinoma in patients with tumour invasion to the portal vein
Gang BAI ; Baoan QIU ; Hongwei BAI ; Nianxin XIA ; Peng LIU
Chinese Journal of General Surgery 1997;0(06):-
Objective To discuss the resection technique for pancreatic carcinoma in patients with tumour(invasion) to the portal and/or superior mesentery vein,and the clinical significance of palliative resection of pancreatic carcinoma.Methods The clinical data of 71 cases of pancreatic carcinoma operated on within a period of 3 years were retrospectively reviewed.In patients with tumour invasion to the portal vein,a method of direc transection of pancreas was used in resection of the tumor,and was combined with local radiotherapy and chemotherapy.Results The resection rate was 57.75%.The complication rate was 22.54%.One patient died of multiple organ failure resulting from pneumonia.The survival rate at 6m,1-and 2-years was 100%,81.69%,and 40.85% respectively.Conclusions The direct transection method of pancreas(resection) is a simple and safe method to increase resection rate and prolong survival time for patients with(advanced) pancreatic carcinoma.
5.The value of DWI and ADC of 1.5T magnetic resonance in differential diagnosis for localized prostate cancer, chronic inflammatory response and benign hyperplasia
Peng WANG ; Yu BAI ; Hongqiang XUE
China Medical Equipment 2017;14(8):80-83
Objective:To compare and analyze the value of diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) of 1.5T magnetic resonance (MR) in differential diagnosis for localized prostate cancer, chronic inflammatory response and benign hyperplasia.Methods: 80 patients with localized prostate cancer were enrolled in the research. The signal to noise ratio (SNR) of DWI, ADC value and semi-quantitative classification of DWI on lesions were measured, and the diagnostic efficiencies of them were compared by using ROC curve.Results: In the 80 patients with localized prostate cancer patients, there were 52 malignant lesions and 43 benign lesions in peripheral band, and there were 31 malignant lesions and 46 benign lesions in central gland. The ADC values of prostate cancer in peripheral band and central gland were 0.91±0.12 and 0.86±0.15, respectively, and they were significantly lower than that of normal tissue (1.68±0.23 and 1.28±0.31) and benign lesions (1.24±0.21 and 1.12±0.16). The semi-quantitative classifications of DWI for benign lesions were significantly higher than that for malignant lesions in peripheral band and central gland, respectively (x2=20.88,x2=12.14;P<0.05). For the diagnostic efficiency of ADC, the sensitivities of benign and malignant lesions in peripheral band and malignant gland were 91.3% and 79.1%, respectively, and the specificities of them were 89.6% and 70.2%. And they was significant higher than the corresponding sensitivities (71.2% and 51.3%)and specificities (78.4% and 65.8%) of DWI imaging.Conclusion: Both of DWI and ADC of 1.5T magnetic resonance are the important indexes in differential diagnosis for prostate cancer, chronic inflammatory response and benign hyperplasia, while ADC value is better than DWI image in the clinical efficiency.
6.Helicobacter pylori and gastric stump cancer
Houqiao BAI ; Peng GAO ; Guosheng JIANG
Journal of International Oncology 2017;44(5):390-392
The gastric stump cancer is closely associated with Helicobacter pylori.Helicobacter pylori can promote the proliferation of gastric remnant mucosa epithelial cells,the production of nitroso compounds in gastric juice and abnormal expressions of some genes in human body,and finally to promote the occurrence of gastric stump cancer.The eradication of Helicobacter pylori infection is expected to reduce the incidence of gastric stump cancer.
7.The relationship between MMP-1 genetic polymorphisms and dental implant early failure in Chinese Han nationality
Chongqing Medicine 2017;46(5):635-637
Objective To make clear the relationship between the genetic polymorphism of MMP-1 and implant early failure.Methods We conducted a case control study,53 cases patients (no smoking history and without periodontitis) who have underwent dental implant were divided into experimental group(with dental implant failure) and control group(with dental implant success) according to early failure of dental implant (within one month).DNA of 53 patients in Han nationality were extracted by using Chelex-100 method and polymorphisms of the mmp-1-1607 gene were detected by restriction fragment length polymorphism after polymerase chain reactions.Results Patients with MMP-1-1607(1G/2G) genotype exhibited a significantly higher occurrence of implant early failure than those with MMP-1-1607(1G/1G) gene type(P<0.05).The OR of the 1G/2G versus the 1G/1G of the MMP-1-1607 genotype was 13.894(P<0.05).Conclusion MMP-1-1607(1G/2G) genotype is associated with implant early failure.
8.The Clinical Analysis of Microsurgical Treatment for Anterior Communicating Artery Aneurysm Via Pterional Approach
Ming LI ; Hualin YU ; Peng BAI
Journal of Kunming Medical University 2016;37(11):116-120
Objective To summarize treatment experiences of microsurgical clipping for anterior communicating artery aneurysm via pterional approach.Methods Clinical data of 82 cases undergoing microsurgical clipping for anterior communicating artery aneurysm via pterional approach in the first affiliated hospital of Kunming Medical University from October 2008 to December 2014 were collected and retrospectively analyzed.The patients were divided into different groups by Hunt-Hess illness grading scale,with 11 cases for level 0,7 cases for level Ⅰ,30 cases for level Ⅱ,25 cases for level Ⅲ,8 cases for level Ⅳ,and 1 cases for level Ⅴ.Twenty-one patients underwent operation at early stage of SAH (<3d),15 at late stage of SAH (4d~2W),and 35 at prolonged stage of SAH (>2W).The prognosis of patients was evaluated according to GOS classification criteria at discharge.Results A total of 85 ACoAA were found in 82 patients and all of them were clipped and,at the same time,3 aneurysms were resected and 11 thrombuses were punctured,cut and removed.In the operation,15 (17.6%) aneurysms ruptured again and temporary blocking happened for 73 times,with the shortest blocking time of 2 rmin,the longest of 40 rmin,and the average of 9.26min.According to GOS score,good recovery rate was 79.3% (65/82),moderate disability rate was 12.2% (10/82),severe disability rate was 3.7% (3/82),vegetative state rate was 0%,and death rate was 4.9% (4/82).Good recovery rates for the operations at early,late and prolonged stage of SAH were 85.7%,73.3% and 82.3% respectively and for level 0 to level Ⅴ were 90.9%,85.6%,86.7% and 84.0%,25.0% and 0.0% respectively.Results of DSA or CTA re-examination upon 55 patients followed-up at discharge or three months after discharge showed that tumor pedicle were clipped and aneurysm disappeared.Fifty cases were followed up from four months to seven years after the operation,with one case of aneurysm recurrence.Another thirty-two cases were lost to follow-up.ConclusiornS Microsurgical techniques and microdissection are keys to successful operation.Pterional approach can guarantee successful clipping of aneurysms with different directions,locations and sizes.It is also an easy,effective and reliable approach with less postoperative complications.Operation for anterior communicating artery aneurysm should be performed as early as possible.
9.Post-operational surgery of colorectal cancer for metastatic tumor on caudate lobe of liver:report of 18 cases
Baoan QIU ; Peng LIU ; Gang BAI
Medical Journal of Chinese People's Liberation Army 1981;0(04):-
Objective To evaluate the techniques and effects of post-operational surgery of colorectal cancer for metastatic tumor on caudate lobe of liver. Methods For the patients admitted from Jan. 1999 to Jan. 2007 to the Navy General Hospital of PLA and undergone metastasectomy on caudate lobe of liver after colorectal cancer operation, the operative procedure and effects were studied retrospectively. Results A total of 18 cases of metastasectomy on caudate lobe of liver were successfully performed. The mean diameter of the metastases was 6.3cm (3.2-11.3cm). The types of operation included total caudate lobectomy (6 cases), total caudate lobectomy combined with extended hepatectomy (9 cases) and partial caudate lobectomy (3 cases). The mean operative time was 198min (154-360min) and the average intraoperative blood loss was 975ml (400-3250ml). No intraoperative death occurred, while the remarkable complications were found in 5 cases (27.8%). The survival rates of follow up for 1, 3 and 5 years were 83.3%, 61.1% and 27.8%, respectively. Conclusions The metastases on caudate lobe of liver after colorectal carcinoma resection usually involve all the hepatic portals. Surgical resection, though sophisticated in technique, remains to be a safe and effective treatment, and the first choice for treating metastases.
10.Degenarative necrosis and calcification of hepatic cycstic echinococcosis
Peng CONG ; Lei BAI ; Jinming ZHAO
Chinese Journal of General Surgery 2011;26(7):600-602
Objective To study factors associated with necrosis and calcification of cyst echinococcosis. Methods This study retrospectively analyzed 191 cases of hepatic cycstic echinococcosis admitted from 2005 to 2008 in the First Affiliated Hospital of Xinjiang Medical University Department of General Surgery, possible relevant factors screened were the patients' gender, age, operation frequency, hepatitis, gall stones, calcium of blood serum, multiple hepatic hydatid cyst, biliary fistulae and hepatic cycstic echinococcosis degeneration. Single-factor analysis and multi-factors analysis were conducted. Results The single-factor independent samples t-test showed that age is significantly related to hepatic cycstic echinococcosis degeneration (t = - 2. 455, P = 0. 008). Single factor Chi-square test showed that factors impacting on hepatic cycstic echinococcosis degeneration were multiple hepatic hydatid cyst and the biliary fistulae (x2 = 6. 848, P = 0. 009; x2 = 7. 149, P = 0. 008). The multiple-factor Logistic regression analysis showed that the age, the multiple hepatic hydatid cyst, and biliary fistulae are the related risk factors(x2 =5. 306,P = 0. 021,OR = 1. 665;x2 = 10. 377,P =0. 001,OR =3. 300;x2 = 4.455,P =0. 035, OR =2. 164) of hepatic cycstic echinococcosis patients with cyst echinococcosis degeneration. Conclusions Age, multiple hepatic hydatid cyst and biliary fistulae are the risk factors associated with degenerative necrosis and calcification of hepatic echinococcosis.