Objective To evaluate the effectiveness of differentiation acupoint massage on the level of blood pressure control and self-efficacy in the elderly with hypertension with yin-deficiency and yangexcess under the model of empowerment education.Methods 80 elderly with hypertension with yin-deficiency and yang-excess were randomly divided into the intervention group and the control group with 40 patients in each group.Both of them received health education of differentiation acupoint massage consisted of 4 weekly sessions.The intervention group received it under the model of empowerment education whilst the other under the model of the general health education.After 4 weeks of sessions,all patients were followed up for 3 months.The blood pressure value was measured before the sessions and 4 weeks and 3 months after the sessions.The scores of self-efficacy was collected before and 3 months later.Results There were significant differences in the blood pressure,self-efficacy between the two groups after the intervention.Conclusions Differentiation acupoint massage under the model of empowerment education can significantly improve patients'self-efficacy and decrease the level of the blood pressure.

An improved and practical synthesis of racemic 11-demethylcalanolide A [(±)-1] was developed. This improved process involved Pechmann reaction on phloroglucinol with ethyl butyrylacetate to give 5, 7,-dihydroxy-4-n-propylcoumarin(3). Poly phosphoric acid (PPA) catalyzed acylation of compound(3) with crotonic acid, then intramolecular cyclization was achieved simultaneously in one step to afford the key intermediate chromanone(4). A microwave assisted synthetic method preparing chromene(6) using chromenynation of chromanone(4) with 1, 1-diethoxy-methyl-2-butene was conducted. Luche reduction of chromene(6) using NaBH<,4> with CeCl3·7H2O preferably gave (±)-1. The overall yield of this four step synthesis of (±)-1 was around 32% increasing one fold more than that of the previous method. An in vitro investigation showed that (±)-1 exhibited inhibitory activities against both wild-type and drug-resistant HIV-1 in HIV-1 RT and cell culture assay, and significant synergistic effects in combination with AZT, T-20, and indinavir. Its LD50 of acute toxicity in mice by intragastric administration and by intraperitoneal injection were 735.65mg·kg-1 and 525.10mg·kg-1, respectively. The C<,max> and AUC<,0-∞> were 0.54μg·mL-1 and 1.08(μg·mL-1)·h, respectively. The dynamics study of the inhibition of mice sera on HIV-1 RT showed that mice treated with 100mg·kg-1 (±)-1 once intraperitoneally were similar to that of 5mg·kg-1 of known clinical effective anti-HIV-1 drug neverapine. The results suggested that further investigation of the anti-HIV candidate (±)-1 was warranted.