OBJECTIVE:To conduct a pharmacognostical study of Rosa laevigata so as to provide scientific evidence for clinical application and development of this herbal plant. METHODS:The pharmacognosy of R.laevigata was studied from aspects of its plant resource,characteristics,microscopic and physiochemical identifications,etc. RESULTS:The R.laevigata was distinctive in plant resource,characteristics,and microscopic and physiochemical identifications. CONCLUSION:The results of the study serve as scientific evidences for clinical application and development of R.laevigata.

Objective To study the quality control method of Feireqingjie Oral Liquid. Methods UV was used to determine the content of total flavonoid. Cortex Mori was identified qualitatively by TLC. Pheretima was identified qualitatively by PC. Results Total flavonoid showed a good linear relationship in the range of 0.005 26-0.052 60 mg/mL, r=0.999 8. The average recovery rate was 98.65%, RSD=0.28% (n=6). The TLC spot of Cortex Mori was coincident with the standard reference, and Pheretima showed the same color as the reference in PC, with no interference of negative control. Conclusion The method is convenient, accurate and can be used as one of the quality control methods of Feireqingjie Oral Liquid.

Objective　To evaluate the value of CT MRI in diagnosing skull base chondromas.Methods　8 cases of skull base chondromas were analyzed with etiology,pathology,imaging fetures and differential diagnosis.5 cases were female,3 cases were male,age ranged from 25 to 48 years.The clinical presentation of 8 cases of skull base chondromas had neurologic syndrome.And 3 cases were examined with CT,MR imaging ,4 cases with MR imaging,1 case with CT scanning.Results　In this series of 8 chondromas,3 located in the cavernous sinus,2 in the clival region,2 in the region of jugular foramen,1 in the frontal cranial fossa.Intratumoral calcification was found in 4 cases with CT examination.Heterogeneous enhancement was found in 4 cases with CT examination.The margin of chondromas on CT was well defined.Conclusion　CT have a very important diagnosis values for detecting tumors on chondromas.MRI is superior to CT for delineating the growth style of the tumor and its relationship to the surrounding anatomic structures.

AIM: To investigate whether three-dimensional time-of-flight magnetic resonance angiography (3D TOF MRA) can be used as a reliable screening tool for evaluation of intracranial vascular stenosis and occlusive disease before stent implantation. METHODS: Thirty-three patients with suspected intracranial arterial stenosis received 3D TOF MRA and digital subtraction angiography (DSA) examinations in Chaoyang Hospital Affiliated to Capital Medical University between March 2007 and April 2008,and were included for this study. Two physicians blindly estimated stenosis,patient history,and clinical information of 363 vascular segments from 33 patients,including bilateral internal carotid artery (ICA),anterior cerebral artery (ACA),middle cerebral artery (MCA),posterior cerebral artery (PCA),vertebral artery,and basilar artery (BA). Stenosis was categorized as 30%-49%,50%-69%,70%-99%,and 100%. For each kind of stenosis,sensitivity,specificity,positive predictive value,negative predictive value,K and P values of MRA were calculated,respectively,as compared to DSA. RESULTS: A total of 42 diseased vascular segments were identified. Compared to DSA,for intracranial stenosis 50%-69%,3D TOF MRA showed sensitivity 100%,specificity 96.8%,positive predictive value 62.1%,negative predictive value 100%,K value 0.751,and P value 0.000; For intracranial stenosis 70%-99%,the corresponding value was 100%,98.6%,70.6%,100%,0.821,and 0.000,respectively; For intracranial stenosis 30%-49%,it was 25.0%,99.7%,66.7%,98.3%,0.356,and 0.000,respectively.CONCLUSION: For high sensitivity and specificity to intracranial stenosis 100%,70%-99%,or 50%-69%,compared to DSA,3D TOF MRA is a reliable screening tool for preoperational evaluation of intracranial vascular stenosis and occlusive disease.

Objective To further understand choledoch stone in the elderly so as to guide the clinical work.Methods The clinical data of 223 elderly patients with choledoch stone were retrospectively analyzed.The clinical characteristic and treatments to the patients were summarized.Results The patients usually presented with nausea and vomiting (86.1％,192/223),fever (84.8％,189/223),jaundice (70.0％ 156/223),abdominal pain (65.0％,145/223) and combined septic shock (20.2％,45/223).Colibacillus (41.0％,66/161) and Klebsiella pneumoniae (27.3％,44/161) were the most predominat.Imipenem,meropenem,amikacin,piperacillin/tazobactam and moxifloxacin were sensitive antibiotics(＞ 80％).Endoscopic sphincteropapillotomy(EST) with injected sensitive antibiotics was effective treatment.Conclusion Treatment of endoscopic sphincteropapillotomy and injected sensitive antibiotics was effective for elderly patients with choledoch stone.

Objective To investigate the effect of ultrasound technology combined with Seldinger technique in the catheteration of peripherally inserted central catheter(PICC).Methods One thousand and eight malignant tumor patients undergoing PICC catheteration were divided into two groups:those with visible or palpable bouncy vein as the control group(n=540)and those with invisible or impalpable elbow vein as the experiment group(n=468).The control group were treated with PICC catheteration into the elbow vein as normal control group and in the experiment group the catheteration was done into the lower part of the upper arm of the basilic vein or brachial vein as the puncture point under the guidance of ultrasound with Seldinger technique.The two groups were compared in terms of success rate of one time puncturing, success rate of one time catheterization and postoperative phlebitis,venous thrombosis and catheter related infection rate.Result There were no significant difference in the success rate for one time puncturing,while the success rate of one time catheterization in the experiment group was significantly higher than that in the control group and the mechanical phlebitis,venous thrombosis,catheter related infection rate in the experiment group were significantly lower than those in the control group(P<0.001).Conclusion Ultrasound technology combined with Seldinger technique for PICC catheterization can obtain high success rate,lower postoperative complications and provide high security.

Objective To assess the diagnostic value of determining infarct core and penumbra using CT perfusion source images (CTP-SI) mismatch model in hemispheric stroke less than 9 hours.Methods "one-stop shop" CT examination including non-contrast enhanced CT (NCCT), CTP, CT angiography (CTA) were performed in 24 patients with symptoms of stroke less than 9 hours.The Alberta Stroke Program Early CT Score (ASPECTS) were analyzed on arterial phase CTP-SI and venous phase CTP SI using Wilcoxon rank-sum test, then compared with the follow up imaging ASPECTS using multiple linear regression.Results The median (min-max) scores of ASPECTS on arterial phase CTP-SI, venous phase CTP-SI and follow-up imaging were 9.0 ( 2.0-10.0 ), 9.3 ( 6.5-10.0 ) and 9.0 ( 7.0-10.0 ),respectively. ASPECTS measured on arterial phase CTP-SI significantly differed from the ASPECTS on venous phase CTP-SI ( Z =-2.812, P = 0.005 ).Moreover, the linear regression analysis showed significant correlation between the ASPECTS on venous phase CTP-SI and follow up imaging ASPECTS ( Beta =0.715,P = 0.003 ).Conclusion CTP-SI mismatch model provides a method of choice in predicting penumbra and infarct core in hemispheric stroke.

Objective To study influences of intervention in pregnant women with positive thyroid autoantibodies on the thyroid function of babies. Methods A total of 55 pregnant women were enrolled with positive thyroid peroxidase antibody (TPOAb) and/or thyroglobulin antibody (TgAb) during prenatal checkup. They were randomly divided into two groups: intervening group( n= 36, newborn group A) was treated with levothyroxine ( L-T4 ), and non-intervening group ( n= 19, newborn group B) was not treated. 30 cases of pregnant women with negative thyroid autoantibodies served as a normal population control group (newborn group N). Serum TSH, TPOAb, TgAb, TT3, TT4, FT3 and FT4 were measured by high-sensitive immunochemiluminescent assay ,and urinary iodine was also examined in the pregnant women. Fetal plasma TSH, TT3, TT4, FT3, and FT4 levels were measured after cutting the umbilical cord from placenta, and repeated measurements were made by 3-4 weeks and 8-10 weeks postpartum. Results At baseline, serum TSH levels of the pregnant women in intervening and nonintervening groups were significantly higher than that in control group ( P＜0.05 ). Non-intervening group had higher TSH and lower TT3, TT4, FT4 compared with the other two groups (P＜0. 05 or P＜0.01 ). The cord blood TSH levels of the neonates in both group B [(7.06 ± 1.31 ) mIU/L] and group A [(6.23 ± 1.26 ) mIU/L] were significantly higher than that of group N [(5.48±1. 17) mIU/L, P＜0.01 and 0. 05]. By 3-4 weeks postpartum,the serum TSH level [(3.21±0.70)mIU/L] in group B was significantly higher than those in group N [(2.72±0.51)mIU/L] and group A [(2.78±0.42) mIU/L, all P＜0.05]. The serum TSH level in group B [(2.99±0.57) mIU/L] was still higher than those in group N [(2.48±0.68) mIU/L] by 8 to 10 weeks postpartum (P＜0.05 ). Multiple stepwise regression analysis revealed that TSH, TPOAb, and urine iodine levels of mothers were independently related to TSH of their infants. Conclusion When differences in thyroid function exist in pregnant women, these differences also reside in their offspring. The thyroid function in neonates correlates with both the thyroid autoantibodies and thyroid function of their mothers.

Objective To evaluate CT and MRI for the diagnosis of cranial extradural empyema.Methods The imaging features in 4 patients with cranial extradural empyema were analyzed.Results 2 cases in frontal,1 case in frontalparietal,1 case in posterier cranial fossa,in this series of 4 cranial extradural empyemas was found homogenous enhancement of dural,and thickened meninges surrounding the empyema.In the series of 1 case show bony thickening and thin.Conclusion The CT and MR of cranial extradural empyema can well demonstrate the morphological and pathological evidence of ivolved menings.Therefore,CT and MR is the most diagnostic value in cranial extradural empyema.

Objective To systematically review the clinical effectiveness of Chinese medicine in treating nasopharyngeal carcinoma patients with radioactive xerostomia. Methods The randomized or semi-randomized controlled trials of the Chinese medicine for nasopharyngeal carcinoam patients with radioactive xerostomia were screened out by online retrieving and manual retrieving of domestic and oversea databases such as Cochrane Library, JBI Library, PubMed, OVID, EMBase, Web of Science, CNKI, Wanfang Database, VIP Database, CBM Database. The data extract and quality assessment were performed by two reviewers independently. Meta-analysis was conducted for the included trials. Results Eight trials were included. The results of Meta-analysis showed that Chinese medicine can effectively delay the progress of oral mucous membrane ulcer in nasopharyngeal carcinoma patients after radiotherapy, and decrease the incidence of grade 3-4 oral mucous membrane ulcer ( Z=4.86, P<0.00001) . Conclusion Chinese medicine has certain effect in treating nasopharyngeal carcinoma patients with radioactive xerostomia.