[ Objective ] To explore the relationship between outpatients amount and climate in Guangzhou City. [Methods] Correlation regression analysis of the relationship between monthly outpatients amount and simultaneous meteorological indexes was carried out in various departments of three hospitals of Guangzhou from the year of 1993 to 2001. [Results] The main meteorological factors affecting monthly outpatients amount are: monthly average atmospheric pressure, monthly lowest temperature, monthly sunshine hours, monthly rainfall, monthly relative humidity and monthly average wind speed. Monthly average atmospheric pressure, monthly lowest temperature, monthly relative humidity and monthly average wind speed are negatively correlated with monthly outpatients amount while monthly sunshine hours and monthly rainfall are positively correlated. Then the corresponding multivariate linear regression equations are established. The results of analysis showed that the main meteorological indexes which were related to the occurrence of diseases are the above six. [Conclusion] The corresponding multivariate linear regression equations can be used to forecast the epidemic trend of diseases in an area and this will provide evidences for the forecast of occurrence and prevalence of diseases.

Objective To evaluate the relationship between genetic polymorphism of transforming growth factor (TGF)-β1 and susceptibility of liver cirrhosis after hepatitis B virus infection in Chinese population. Methods CBM, VIP, CNKI, Wanfang technological periodical full-text databases and Pubmed from set up to July, 2013 were electronically searched to identify case-control studies on the relationship between genetic polymorphism of TGF-β1 promoter 509 site, co-don 869 site and liver cirrhosis after hepatitis B virus infection. The data were quantitatively analyzed by RevMan 5.1 soft-ware after assessing the quality of included studies. Results Six case-control studies were selected for Meta-analysis based on our inclusion and exclusion standards. The results of Meta-analysis showed that the pooled OR value for liver cir-rhosis among Chinese patients after hepatitis B virus infection with T allele of TGF-β1 gene at promoter 509 was 1.02 (95%CI:0.67-1.54), the pooled OR values for patients with TT and CT genotypes were 0.80 (95%CI:0.36-1.78). OR values for pa-tients with C allele of TGF-β1 gene at codon 869 was 1.05 (95%CI:0.69-1.62), the pooled OR values for patients with CC and CT genotypes were 0.98 (95%CI:0.48-2.00). No significant publication bias was found. Conclusion The genetic poly-morphism of TGF-β1 at promoter 509 and codon 869 showed no association with susceptibility of liver cirrhosis after hepati-tis B virus infection in Chinese population.