Objective To explore the outcomes of radiotherapy and zoledronic acid in patients with bone metastasis.Methods 48 cancer patients with bone metastasis,were divided into two group,control group received radiotherapy only,therapy group received radiotherapy and zoledronic acid.Remission of ostalgia was evaluated after 3-6 months.Results The total effective of remission of ostalgia had no significant differences between two group(83.3 ％ vs 79.2％,P ＜ 0.05).But rate of complete remission therapy group was higher than that of control group(50.0％ vs 33.3％,P ＜ 0.05).The adverse reaction aer resemble between the two group.Conclusion The outcomes of radiotherapy and zoledronic acid in patients with bone metastasis is effectiveness for cases with bone metastasis,is worth spreading.

Objective To investigate the clinical effects of different dose of remifentanil with double-tube type laryngeal mask airway (LMA) ventilation in the aged patients undergoing total hip-arthroplasty (THA).Methods Sixty ASA class Ⅰ-Ⅱ grade patients undergoing THA were enrolled in the study.The patients were divided into three groups according to remifentanil dose with 20 cases each,0.2 μ g/ (kg· min)group,0.3 μ g/(kg· min) group and 0.4 μ g/(kg· min) group.Heart rate and mean arterial pressure (MAP)were measured immediately before anesthesia induction,immediately after anesthesia induction,immediately after inserting LMA,the set of operation,15 min during operation and discontinuation of anesthetic.Results All patients were successfully operated without intraoperative awareness.In 0.2 μ g/(kg·min) group,the patients suffered from the heart rate and MAP fluctuations,the high incidence of body movement (45.0％,9/20),and the maximum amount of propofol [(82.4 ± 21.6) mg].In 0.3 μg/(kg· min) group,heart rate and MAP had the better fluctuation,and patients might wake up faster postoperatively.In 0.4 μ g/(kg· min) group,heart rate and MAP significantly decreased,the amount of efedrina [(5.2 ± 4.3) mg] was the largest in the three groups,the recovery time [(5.2 ± 1.3) min] was the longest Conclusion Remifentanil 0.3 μg/(kg·min) compound with propofol with double-tube type LMA can be used for total intravenous anesthesia in the elderly patients with THA,with hemodynamic stability,fewer complications,and reliable ventilation.

OBJECTIVE:To observe the efficacy and safety of methylprednisolone combined with entecavir in the treatment of primary nephrotic syndrome with hepatitis B virus infection. METHODS:23 primary nephrotic syndrome patients with hepatitis B virus infection were given 0.5 mg/times Entecavir tablet,orally,once a day,for 2 weeks,and added 0.8mg/(kg.d)Methylpredniso-lone tablet,orally,once a day,for 8 weeks,then the dose was maintained for 2-3 months every other day,and then decreased 4 mg for 4 weeks every other day,and the dose was decreased 4 mg every 2-4 weeks,until drug withdrawal. Entecavir tablet was used in the whole process of Methylprednisolone tablet,the dose was adjusted and gradually stopped based on HBV-DNA within 3 months of Entecavir tablet withdrawal. Liver and renal efficacy,24 h urine protein excretion,serum albumin(ALB),alanine ami-notransferase(ALT),aspartate aminotransferase(AST)levels before and after treatment of 2,6,12 and 15 months,and the inci-dence of adverse reactions of all patients were observed. RESULTS:The liver and renal efficacy were 100%;after treatment of 2, 6,12 and 15 months,24 h urine protein,ALT and AST were significantly lower than before and gradually decreased by time, ALB was significantly higher than before and gradually increased by time,the differences were statistically significant(P<0.05);the incidence of adverse reactions was 43.48%,and there were no obvious adverse reactions and no renal dysfunction. CONCLU-SIONS:Methylprednisolone combined with entecavir has significant efficacy in the treatment of primary nephrotic syndrome with hepatitis B virus infection,with good safety.

Lipoxins possess a wide spectrum of adjustment function for various inflammatory cell functioning and the expression of inflammatory related genes,also progressing the inflammatory response by means of various cell.Lipoxins play an important role in the pathogenesis and clinical treatment of kidney diseases.

Objective To analyze the detection results of blood fat and proinsulin related indicators in the patients with type 2 diabetes mellitus(T2DM ) and to investigate the means for improving the patients′ clinical indicators .Methods 57 patients with T2DM in our hospital from February 2013 to February 2015 were divided into the research group ( ≥ 15 .6 mIU /L ,29 cases) and the control group (< 15 .6 mIU /L ,28 cases) according to the proinsulin level .All the cases took glucose ,at the same time the cor‐relation between the blood fat indexes with serum true insulin ,proinsulin and insulin resistance index of steady state insulin assess‐ment model was analyzed .Results Proinsulin ,serum true insulin ,2 h postprandial proinsulin ,2 h postprandial serum true insulin , insulin resistance index of steady state insulin assessment model all had correlation with and apolipoprotein B /apolipoprotein A1 . Conclusion The proinsulin level in the patients with T 2DM is increased ,thus the ratio of apolipoprotein B/apolipoprotein A1 will be accordingly increased .

Objective To analyse the clinical value of aspartate aminotransferase mitochondrial isoenzyme (m‐AST ) determina‐tion in patients with alcoholic liver disease .Methods 61 cases of patients with alcoholic liver disease (observe group) receiving treatment in this hospital from March 2013 to March 2015 and 61 cases of healthy individuals(control group) were enrolled in this study ,and serum levels of m‐AST ,alanine amino transferase(ALT) ,aspartate amino transferase(AST) and γ‐glutamyl transferase (GGT) were detected .Results Compared with the control group ,serum levels of of m‐AST ,ALT ,AST and GGT were increased in the observe group ,there were statistically significant differences (P<0 .05) .In patients with alcoholic liver disease ,after treatment , serum levels of m‐AST ,ALT ,AST and GGT were different among patients with hepatic adipose infiltration ,patients with hepatitis and patients with liver cirrhosis ,there were statistically significant differences(P<0 .05) .Conclusion Combined with ALT ,AST and GGT ,m‐AST could be utilized as an indicator for diagnosing alcoholic liver disease ,which has clinical significance .

AlM: To evaluate the clinical effect of implantation of phakic anterior chamber iris clip intraocular lens in high myopia patients.
METHODS: Fifty eyes of 28 high myopia patients with anterior chamber phakic Verisyse iris clip intraocular lens implantation were observed. The visual acuity, best corrected visual acuity, intraocular pressure, corneal and anterior chamber inflammation changes were observed after the procedure.
RESULTS: Fifty eyes of 28 high myopia patients were successfully accepted implantation of phakic anterior chamber iris clip intraocular lens. Visual acuity of all the patients was increased after operation. And one year later, visual acuity of 38 eyes ( 76%) ≥1. 0, 12 eyes (24%) ≥0. 5, best corrected visual acuity of 40 eyes (80%) ≥1. 0, 10 eyes ( 20%) ≥0. 5. ln 22 eyes, the postoperative best corrected visual acuity were reached and exceeded preoperative best corrected visual acuity.CONCLUSlON: lmplantation of iris clip intraocular lens in high myopia patients with anterior chamber lens was feasibility and effective.

Thyroid associated ophthalmopathy (TAO) is often shown as upper eyelid retraction,conjunctival hyperemia and edema,proptosis,diplopia,strabismus and decreased visual acuity.It is difficult to make a certain diagnosis in the early stage of TAO.Patients suffering from TAO often have upper eyelid retraction at the early stage of disease,which affects appearance and causes feelings of discomfort and decreased visual acuity.Learning more about upper eyelid retraction contributes to the early diagnosis and treatment of TAO.Although upper eyelid retraction with TAO has distinctive manifestations,it is easy to misdiagnose.The differential diagnosis includes congenital eyelid retraction,neurological disorders,high axial myopia,glaucoma filtering bleb,and so on.Family history,clinical manifestations and TAO related examinations should also be taken into consideration.Comprehensive treatments should be adopted.Glucocorticoids and eyelid retraction surgeries are current mainstay of treatment.There are controversies on the application of glucocorticoids about the specific dosage,while agreement achieved that the cumulative dose should not be more than 8 g in one stage in order to reduce the risk of liver failure and other adverse events.Different operation methods should be chosen according to the degrees of retraction and causes of disease for each type of patients.In addition,special attentions should be paid to the decrease of muscle strength in the temporal side.Individual analysis is needed in order to diagnose and treat upper eyelid retraction with TAO.Early diagnosis and intervention can improve the appearance,visual function and quality of life of the patients.