1.Skin Metastasis, An Uncommon Course Of Prostate Carcinoma: A Report Of Two Cases
Leon Telis ; Vira Wolf ; Oksana Yaskiv ; Barry J Pearson ; Maria Katsigeorgis ; Seyed Behzad Jazayeri ; David B Samadi ; Pamela D Unger
The Malaysian Journal of Pathology 2016;38(2):165-168
Prostate cancer is one of the most common cancers among men worldwide and in the USA. Most
prostate cancer progression either locally invades to seminal vesicles or metastasizes distally to bone.
Skin is not a common site of metastasis for the majority of malignancies including prostate cancer.
This paper reports two extremely rare cases of prostate carcinoma metastatic to the skin: a 74-year-old
man previously treated with radiation for prostate cancer with cutaneous metastases to the shoulder
and a 68-year-old man with prostate adenocarcinoma and cutaneous metastases to the groin. Both
patients were diagnosed with skin punch biopsy and later confirmed with immunohistochemical
staining for PSA and prostate specific acid phosphatase, specific for prostatic carcinoma. Although
unusual, development of multiple skin lesions in patients with prostate adenocarcinoma should raise
the flags of cutaneous metastases.
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