1.Case Reports on Black Fungus of the Gastrointestinal Tract: A New Complication in COVID-19 Patients
Sachin ARORA ; Ashish SINGH ; Pallavi PRASAD ; Rahul ; Rajneesh SINGH
The Korean Journal of Gastroenterology 2023;81(5):221-225
Gastrointestinal mucormycosis is a rare disease with a significant mortality rate, even when promptly diagnosed and treated. An unusual complication was observed in India during the second wave of coronavirus disease 2019 (COVID-19). Two incidences of gastric mucormycosis were found. A 53-year-old male patient with a history of COVID-19 one month earlier came into the intensive care unit. After admission, the patient developed hematemesis, which was initially treated with blood transfusions and digital subtraction angiography embolization. Esophagogastroduodenoscopy (EGD) revealed a large ulcer with a clot in the stomach. During an exploratory laparotomy, the proximal stomach was necrotic. Histopathological examination confirmed mucormycosis. The patient was started on antifungals, but despite rigorous therapy, the patient died on the tenth postoperative day. Another patient, an 82-year-old male with a history of COVID-19, arrived with hematemesis two weeks earlier and was treated conservatively. EGD revealed a large white-based ulcer with abundant slough along the larger curvature of the body. Mucormycosis was verified by biopsy.He was treated with amphotericin B and isavuconazole. He was discharged after two weeks in a stable condition. Despite quick detection and aggressive treatment, the prognosis is poor. In the second case, prompt diagnosis and treatment saved the patient’s life.
2.An Insight of Nanomaterials in Tissue Engineering from Fabrication to Applications
Ritika SHARMA ; Sanjeev KUMAR ; Bhawna ; Akanksha GUPTA ; Neelu DHEER ; Pallavi JAIN ; Prashant SINGH ; Vinod KUMAR
Tissue Engineering and Regenerative Medicine 2022;19(5):927-960
Tissue engineering is a research domain that deals with the growth of various kinds of tissues with the help of synthetic composites. With the culmination of nanotechnology and bioengineering, tissue engineering has emerged as an exciting domain. Recent literature describes its various applications in biomedical and biological sciences, such as facilitating the growth of tissue and organs, gene delivery, biosensor-based detection, etc. It deals with the development of biomimetics to repair, restore, maintain and amplify or strengthen several biological functions at the level of tissue and organs. Herein, the synthesis of nanocomposites based on polymers, along with their classification as conductive hydrogels and bioscaffolds, is comprehensively discussed. Furthermore, their implementation in numerous tissue engineering and regenerative medicine applications is also described. The limitations of tissue engineering are also discussed here. The present review highlights and summarizes the latest progress in the tissue engineering domain directed at functionalized nanomaterials.
3.End of induction MRD assessment based early treatment intensification with novel agents in ETP-ALL- may be the way forward
Pritish Chandra PATRA ; Sujay RAINCHWAR ; Reema SINGH ; Rohan HALDER ; Pallavi MEHTA ; Megha VERMA ; Rayaz AHMED ; Jyoti Shankar RAICHAUDHURI ; Dinesh BHURANI ; Narendra AGRAWAL ; Suman PRAMANIK
Blood Research 2023;58(2):112-115
4.Continuous B scan ultrasound guided post-traumatic sub-periosteal orbital hematoma drainage: An advantage over routine needle drainage procedure
Amar Pujari Amar Pujari ; Pallavi Singh Pallavi Singh ; Ayushi Sinha Ayushi Sinha ; Shreya Nayak Shreya Nayak ; Mandeep S. Bajaj Mandeep S. Bajaj
World Journal of Emergency Medicine 2019;10(4):248-250
Traumatic orbital haemorrhage is an unfortunate complication with potential vision-threatening consequences.[1-3] The collection of blood can occur anywhere along the potential free orbital spaces,[4] but the subperiosteal collection of the blood is an important clinical variant where careful and timely intervention can give commendable rewards to the surgeon as well as to the patient.[1,2] Subperiosteal hematoma could be traumatic or non-traumatic, in turns, the non-traumatic cases may be due to bleeding tendency as in cases of leukaemia, blood dyscrasia and haemophilia or could be due to vascular malformation, venous congestion, infection, inflammation and neoplastic and non- neoplastic causes.[4] Here in this report, we elaborate the advantage of continuous ultrasound-guided needle drainage of the post-traumatic subperiosteal hematoma to enhance the clinical accuracy and to avoid the untoward complications.