Objective:To explore the genotype and allele distribution feature of cytochrome P450 2C19 (CYP2C19) in Uighur and Han nationality patients With coronary heart disease (CHD).Methods:A total of 355 CHD patients Without kinship,including 194 Uighur cases and 161 Han cases,Were selected. CYP2C19 genetic polymorphism Was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP),it’ s compared betWeen different age groups (<60 years and≥60 years)of the tWo nationalities.Results:Compared With Han na-tionality patients,there Were significant increase in allele*1 frequency [(64.9% vs.75.2%),P<0.01],signifi-cant decrease in allele*2 (29.5% vs.22.2%),and allele*3 (5.6% vs.2.6%) frequencies (P<0.05 all);geno-type*1/*1 significant increase [(38.5% vs. 57.7%),P<0.01],*1/*2 significant decrease [(44.7% vs. 31.5%),P<0.05],and other four genotype betWeen tWo nationalities Were no significant difference (P>0.05);fast metabolic patter frequency (38.5% vs. 57.7%)significant increase,moderate metabolic patter frequency (52.8% vs. 31.5%)significant decrease (P<0.01 all)in Uighur nationality patients ;In a same nationality,age had no significant impact on its genotype and allele distribution (P>0.05 all).Conclusion:There are significant differences in cytochrome P450 2C19 genotype and allele distribution betWeen Uighur nationality and Han nationali-ty CHD patients,Understanding those is of important significance to guide clinical medication and improve patients' prognosis.

Objective To study the influence of anxiety on left cardiac function in elderly patients with chronic heart failure. Methods 111 cases of chronic heart failure patients with anxiety (anxiety group) and 95 cases of chronic heart failure patients without anxiety (non anxiety group) were selected. General data were collected from patients during hospitalization and the Zung Self-rating Anxiety Scale (SAS)was filled out. Statistical analysis and evaluation of the influence of anxiety on left cardiac function in elderly patients with chronic heart failure was made. Results There was not significant difference (P>0.05) in the gender, age and uric acid between 2 groups, but was (P<0.05) in left ventricular ejection fraction, left ventricular end diastolic dimension, left ventricular end systolic dimension, and cardiac functional grading.Conclusion Anxiety has a strong influence on left cardiac function in elderly patients with chronic heart failure.