Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease and infection is one of the most common complications and death causes of SLE. Vaccination is an effective tool for prevention of infections among SLE patients. This expert consensus was achieved by the Rheumatic Disease Prevention and Control Committee, Zhejiang Preventive Medical Association on the prevention of infections with vaccines, types of vaccines, vaccination timing, efficacy and safety of vaccines and impact of therapeutic agents for SLE on vaccinations to guide the rheumatologists and vaccination professionals for scientific and standardized vaccinations among SLE patients, so as to prevent infection and improve quality of life among SLE patients.

Objective: To investigate the inhibitory effects of antisense oligodeoxynucleotide(ASODN) of signal transducer and activator of transcription 3 (STAT 3) on development and growth of transplanted lung A549 cell adenocarcinoma in nude mice. Methods: The inhibitory effects of STAT 3 ASODN on A549 cell growth was evaluated by CCK-8 assay. STAT 3 ASODN-treated A549 cells were implanted subcutaneously into nude mice; the tumor growth was observed and the tumor-forming rate was calculated. After subcutaneous implantation of the untreated A549 cells, the tumor-bearing mice were randomized into 3 groups: control group, STAT 3 ASODN group, and nonsense oligodeoxynucleotide (NSODN) group, with normal saline, STAT 3 ASODN, and STAT 3 NSODN injected intatumorally (15 mg/kg daily for 3 weeks). The tumor volumes were measured every other day and the tumor weights were determined. The protein expressions of STAT 3 and p-STAT 3 in xenografts were examined by Western blotting analysis. Results: STAT 3 ASODN significantly inhibited the growth of A549 cells compared with STAT 3 NSODN group (P<0.05). The tumor formation ability of A549 cells treated with STAT 3 ASODN was significantly decreased (with the tumor inhibitory rate being 75.8%). Moreover, the growth of transplanted tumor was also significantly inhibited in STAT 3 ASODN group as compared with those in NSODN group and control group (P<0.05) . The tumor weights were significantly reduced in STAT 3 ASODN group than in STAT 3 NSODN group and control group (with the tumor inhibitory rate being 51.1%). The expression of STAT 3 protein and p-STAT 3 was also down-regulated in STAT 3 ASODN group. Conclusion: STAT 3 ASODN can suppress the tumorigenic ability of A549 cells and inhibit the growth of transplanted tumor in nude mice.

Objective: To investigate the incidence and survival rates of primary RCC (renal cell carcinoma) in residents in Pudong New Area in Shanghai. Methods: The residents in Pudong New Area in Shanghai were recruited in this study during the period 2002-2011. The standardized morbidity and mortality of primary RCC were calculated by world standard population. The survival of primary RCC patients according to gender, resident district, TNM staging and surgical operation was analyzed by Kaplan-Meier method and COX regression analysis. Results: Among 1 905 new cases of primary RCC occurring during 2002-2011, 1 234 were males and 671 were females. The age-standardized incidence rate in males (5.17/100 000 person-year) was higher than that in females (3.07/100 000 person-year). In 697 cases of RCC-related death, 453 were males and 244 were females. The age-standardized mortality in males (1.88/100 000 person-year) was higher than that in females (0.92/100 000 person-year). The one-, two-, three-, four-, and five-year survival rates of patients with primary RCC were 74.75%, 69.84%, 66.38%, 63.40% and 61.44%, respectively. There was a statistically significant difference in overall survival between central city vs other areas (P = 0.040), early stage vs advanced stage (P < 0.001), and having surgical operation vs not having surgical operation (P < 0.001). Advanced stage and not having surgical operation were independent risk factors in patients with primary RCC (P < 0.001). Conclusion: The incidence and mortality rates of primary RCC in males and in central city were significantly higher than those in females and in other areas in residents in Pudong New Area in Shanghai, 2002-2011, respectively. Early diagnosis of primary RCC and performance of surgery can significantly improve the prognosis of patients. Copyright © 2013 by TUMOR.

Objective: To analyze the trends of female breast cancer incidence and mortality in Beijing, Shanghai, Linzhou and Qidong in China between 1988 and 2007. Methods: The data of female breast cancer incidence and mortality and the data of corresponding population during 1988-2007 were collected from four eligible cancer registries which could provide complete sets of historical data. The pooled analysis and time-trend analysis of the data were performed. Results: During 1988-2007, the APCs (annual percent changes) of age-standardized incidence rates (by China's population in 1982) of female breast cancer in Beijing, Shanghai, Linzhou and Qidong were 2.49%, 2.55%, 7.04% and 4.16%, respectively. Although the average annual growth of APC of age-standardized mortality was 4.10% in Linzhou, there were no significant changes in Beijing, Shanghai and Qidong. Conclusion: During 1988-2007, the breast cancer incidence and mortality of the urban women in Beijing and Shanghai were significantly higher than those of the rural women in Linzhou and Qidong. The incidence rate of female breast cancer in these four areas showed an obvious rising trend, and this increase was more significant in rural areas. The mortality rate of female breast cancer in Linzhou also showed a rising trend, but the mortality rates in the other three areas remained steady. Copyright © 2012 by TUMOR.

Objective: To describe the incidence and mortality of female breast cancer in China during 2003-2007. Methods: The incidence and mortality data of female breast cancer and the corresponding population data from 32 eligible cancer registries in China during 2003-2007 were collected and analyzed. Results: The combined crude incidence rate of female breast cancer during 2003-2007 was 41.64 per 100 000, which was the highest among female cancer incidence rates. The combined crude mortality rate of female breast cancer was 9.63 per 100 000, which was ranked as the sixth among the mortality rates of all female cancers. The incidence rate was 3.04 times higher and the mortality rate was 1.92 times higher in urban areas than those in rural areas. Compared to the incidence and mortality rates of 184 regions provided from GLABOCAN 2008 database, the female breast cancer incidence in China was ranked as the one hundred and tenth, and the mortality was ranked as the one hundred and seventy-second. Conclusion: Breast cancer has been becoming one of the most common cancers among Chinese women. The incidence and mortality rates of female breast cancer in urban areas are significantly higher than those in rural areas, although the overall incidence and mortality rates of breast cancer in Chinese women are still at a medium or low level in the world. © 2012 by Tumor.

  This center was established at its downtown in 2011. In order to either maintain or promote health-welfare status at the elderly life stage, the center has been providing regular physical exercise courses using hot spring water pumped up there. These activities have been performed cooperating with all 32 community general support centers covered whole the city.  Main findings and indication from our activities in these10 years were as follows:  1．Total number of attendants increased from around 60 to 90 thousands a year. About one fourth of them were the QOL (Quality of Life) tour member aged 65 years or more attending twice a week in every 3-month by the courtesy bus, and the others aged 40 years or more attended with their own ways.   The attendants aged 75 years or more has gradually increased to 70〜80% of QOL tour member. For the other member, it has been in 20〜30% these 10 years.  In addition to the physical exercise in 33〜36°C hot spring water consisted of walking, stretch & flex, aquatic exercise for joint-musculoskeletal pain and others, power-up rehabilitation, exercise for joint-musculoskeletal pain and others were performed on floor, too. The grade of these exercise consisted of 30, 40 and 50% of maximum heart rates depending on physical examination results of 5 m-walk, timed up & go test (TUG), the 30 seconds chair-stand test (CS30), hand grip, functional reach and posture forward bending, and doctors’ inspection.  2．On the follow-up of the physical examinations measured every 3-month, 5 m-walk, hand grip and CS30 were shown to be suitable items due to the availability as the routine examination. The results are substantially useful for reviewing each attendant status in longitudinal course, and indicate our treatments for them.  3．The attendants increased and distributed over the whole city in these 10 years. However, as the proportion of new ones is several percentages each year, the exchange of attendants was less than we expected. This indicates that we should have closer communication with community general support centers in order to distribute our activities to people who need health-welfare promotion, but have never been in the center. On top of that, the usage of our center should be increased for people of middle ages for ideal prevention.

The critical period for the prevention and control of novel coronavirus pneumonia (NCP) in China, in response to requirements for accelerating the modernization of the disease prevention and control system, we analyzed and summarized the current situation, existing problems, and deficiencies in China′s modernization of disease prevention and control system. In addition, we put forward the contents and countermeasures for the modernization of the disease prevention and control system. The modernization of the disease prevention and control system should be built around governance modernization, talent modernization, equipment modernization, scientific research modernization, and modernization of the regulatory system. The countermeasures and suggestions need to reposition the disease prevention and control system, rationalize the management system and operating mechanism, strengthen the modernization of talents and equipment, strengthen scientific research on disease prevention and control, and further improve the disease prevention and control legal system.

Objective To explore the application of extreme learning machine (ELM) model in predicting the incidence of hand-foot-and-mouth disease, and to compare the difference between ELM model and neural network model. Methods The monthly incidence data of hand-foot-and-mouth disease from May 2008 to Jul. 2017 in Zhangjiakou were collected and formed a time series with 111 data. To validate and evaluate the prediction performance of the two models, 75% of the randomly selected dataset were used to train model and the remaining 25% were used as testing data for prediction. Results and conclusion The mean relative errors (MREs) of learning and prediction based on ELM model were 0.05 and 0.07, respectively. The MREs of learning and prediction based on neural network model were 0.09 and 0.12, respectively. The learning and prediction effects of ELM model are better than neural network model. It can improve the accuracy of prediction and has high application value.

  This center was established at its downtown in 2011. In order to either maintain or promote health-welfare status at the elderly life stage, the center has been providing regular physical exercise courses using hot spring water pumped up there. These activities have been performed cooperating with all 32 community general support centers covered whole the city.  Main findings and indication from our activities in these10 years were as follows:  1．Total number of attendants increased from around 60 to 90 thousands a year. About one fourth of them were the QOL (Quality of Life) tour member aged 65 years or more attending twice a week in every 3-month by the courtesy bus, and the others aged 40 years or more attended with their own ways.   The attendants aged 75 years or more has gradually increased to 70〜80% of QOL tour member. For the other member, it has been in 20〜30% these 10 years.  In addition to the physical exercise in 33〜36°C hot spring water consisted of walking, stretch & flex, aquatic exercise for joint-musculoskeletal pain and others, power-up rehabilitation, exercise for joint-musculoskeletal pain and others were performed on floor, too. The grade of these exercise consisted of 30, 40 and 50% of maximum heart rates depending on physical examination results of 5 m-walk, timed up & go test (TUG), the 30 seconds chair-stand test (CS30), hand grip, functional reach and posture forward bending, and doctors’ inspection.  2．On the follow-up of the physical examinations measured every 3-month, 5 m-walk, hand grip and CS30 were shown to be suitable items due to the availability as the routine examination. The results are substantially useful for reviewing each attendant status in longitudinal course, and indicate our treatments for them.  3．The attendants increased and distributed over the whole city in these 10 years. However, as the proportion of new ones is several percentages each year, the exchange of attendants was less than we expected. This indicates that we should have closer communication with community general support centers in order to distribute our activities to people who need health-welfare promotion, but have never been in the center. On top of that, the usage of our center should be increased for people of middle ages for ideal prevention.

In this paper,e-health development and its situation in recent years in China are introduced,and discussed and compared with Chinese and Western e-health differentiation.In addition,the concept and implementation method of e-health have been emphasized,and the importance of e-health in solving Chinese current medical problems has been introduced.