Objective: Social Networking Sites (SNS) are gaining popularity across different cultures and age groups with its increasing role in the day-to-day life of its users. Objective of the present investigation is to study the SNS use and its relationship with online and real-life social capital, self-esteem and interpersonal relationships in normal and clinical population. Methods: The sample consisted of 93 participants of the age range 17-37 years, 63 participants from the general population and 30 from the clinical population with a diagnosis of any depressive or anxiety spectrum disorder. The tools used for this study are Basic Data Sheet, the Facebook Intensity Scale, Internet addiction Test, Internet Social Capital Scale. Results: The Rosenberg Self-Esteem Scale and Sentence Completion Test Results show that Facebook use has a positive correlation with online bonding and bridging capital. A significantly higher percentage of participants from the clinical group met the criteria for problem use of the Internet. Compared to average users, problem users of the Internet are found to have higher mean scores for online bridging capital and conflicts in inter-personal relationships and lower mean scores for real life bonding capital and self-esteem. Conclusions: It necessitates an exploration of Facebook's use patterns in routine evaluation and management of clinical conditions and implies the need for further research to develop explanatory models and management strategies for problematic use of the Internet.

Objective: Human Immunodeficiency Virus (HIV) Key Populations (KPs) include Female Sex Workers (FSWs), men who have sex with men (MSM), transgender (TG), and transsexual (TS) persons. This study assessed coronavirus disease 2019 (COVID-19) vaccine uptake among KPs for HIV in India, adverse events following immunization (AEFI), and breakthrough infections among the vaccinated.Materials and Methods: This retrospective cohort study was conducted among 421 KPs enrolled in 41 Targeted Intervention (TI) clusters in 31 districts of the Tamil Nadu State Acquired Immunodeficiency Syndrome (AIDS) Control Society (TANSACS), India, from June to September 2022. A semi-structured, bilingual (English and Tamil), interviewer-administered questionnaire was used to collect data on socio-demographic characteristics, vaccination status, AEFIs, and breakthrough infections among the KPs under the TIs.Results: Among the KPs, 45.4% were FSWs, 37.1% were MSM, 16.2% were TG, and 1.4% were TS persons. Among them, 4.3% had HIV, and 2.9% had syphilis or other sexually transmitted infections (STIs). The COVID-19 vaccine uptake rate was 96%. Among the KPs, TG/TS persons had the highest vaccine uptake (98.6%), followed by FSWs (96.3%) and MSM (94.2%). AEFIs were reported by 85.4% of the participants. HIV positive status was significantly associated with the incidence of AEFI. The breakthrough infection rate was 5.4% among the vaccinated participants.Conclusion: The COVID-19 vaccine uptake among HIV KPs was high in Tamil Nadu. AEFIs and breakthrough infections among COVID-19 vaccinated HIV KPs may be low, with mild AEFIs.