Objective To explore the curative effect and nursing of gastrointestinal bleeding of somatostatin combined with omeprazole in the treatment of liver cirrhosis. Methods 40 cases of gastrointestinal bleeding in patients with cirrhosis using somatostatin combined with omeprazole treatment, at the same time using conventional nursing (control group), the other 40 patients used somatostatin combined with omeprazole treatment, and comprehensive nursing (observation group); two group intervention. The patients were in our hospital from March 2015 to January 2017 were treated. Results The effective rate of treatment group was two, obviously higher in the observation group, the observation group was 95.0 ％, the control group was 70.0 ％; the satisfaction rate is obviously higher in patients in the observation group, the observation group total the satisfaction rate was 97.5 ％, the control group was 72.5 ％; comparison shows obvious differences(P<0.05). Conclusion Somatostatin combined with omeprazole in the treatment of liver cirrhosis of digestive tract hemorrhage, the treatment can improve the patient's condition, but also the implementation of comprehensive nursing, is conducive to improve the treatment effect of patients, and improve the satisfaction rate of patients for nursing care, it is worthy of reference.