Thrombospondin (THBS) 2, as a member of the THBS family, is expressed in a variety of tumor cells and has important significance in the development and metastasis of tumors. In recent years, studies have reported that the specific role of THBS2 in different tumors is different, and it participates in a variety of biological processes, such as cell apoptosis, wound healing, angiogenesis and inflammation. At present, the role of THBS2 in tumorigenesis, development, and prognosis is not completely clear. Exploring the abnormal expression and mechanism of THBS2 in tumors is expected to provide a new method for tumor diagnosis and treatment.

Objective: To evaluate the effectiveness that gelatin lines the injured vasuclar wall to prevent from restenosis.Methods: The animal model of restenosis was established by balloon dilation in femoral artery,and 30% gelatin was lined on injured vascular wall in experimental group.The samples were collected at the 2nd week and 4th week after operation.The neointimal area(NEA),neointimal area/media area(NEA/MA)and cell apoptosis were observed by image analysis system and TUNEL technique. Results: The intima of the control group was thicker than that of the experimental group,and more cells appeared in the control group.Compared with the control group,the NEA was reduced significantly in the experimental group at the 2nd and 4th week (0.67?0.25cm 2 vs 1.02?0.41cm 2,and 1.18?0.36cm 2 vs 1.46?0.15cm 2).The NEA/MA ratio in the experimental group was lower than the control group at the 2nd and 4th week(0.35?0.05% vs 0.54?0.14%,and 0.62?0.25% vs 0.75?0.10%).The apoptosis rate of vascular smooth muscle in the experimental group was higher than the control group at the 2nd and 4th week(18.2?5.8% vs 13.6?2.4%,and 15.1?2.1% vs 13.0?1.5%).These diffences were all significant (P

Hilar cholangiocarcinoma is a common bile duct cancer.The radical resection rate of end-stage malignancies reported in literature is about 20％.Half of the patients have lost the chance of operation at the time of care,while the average survival time in the patients who can not be operated is about six months.Therefore,for most patients,looking for a palliative treatment which can prolong the survival time is particularly important.From June 2013 to June 2014,our hospital applied iodine-125 brachytherapy,to treat 7 patients with unresectable hilar cholangio carcinoma.All the patients are still alive,the average survival time of 7 patients is 5.2 months up to now,with median survival time being 7.8 months,and longest survival time being 12 months.With good outcomes,few complications,as well as significantly prolonged survival time,iodine125 brachytherapy is regarded with broad clinical applications.

This study was aimed to establish the classification method of Chinese herbal medicine based on feature parameters extracted from images of herbal transverse section, in order to explore the feasibility of automatic identi-fication method of herbal medicine. The extracted 26 parameters of 18 herbal medicine images by gray-level co-oc-currence matrix and grayscale gradient matrix were used as the basic data set. And the minimum covariance determi-nant (MCD) was used to delete the outliers. A total of 18 identification models were established using the native Bayes method and BP neural network methods. The results showed that the average correct rates of models were 90%. It was concluded the feasibility of using these models in the establishment of the automatic identification method of herbal medicines. It provided new technologies for the quantitative, scientific and objective identification of Chinese herbal medicine.

This study was aimed to compare the difference of parameters of texture feature in the transverse section images of the same and different Chinese herbal medicine. A total of 26 parameters of herbal medicines were ex-tracted by gray-level co-occurrence matrix and grayscale gradient matrix. The graph of mutative curve was drawn. And differences of 26 parameters of texture feature in the same and different Chinese herbal medicine were com-pared. The results showed that parameters of texture feature extracted by gray-level co-occurrence matrix and grayscale gradient matrix had similarities and differences in the same and different Chinese herbal medicine. It was concluded that the method can show the texture feature scientifically and quantitatively. It also laid a foundation for the establishment of an automatic identification model, but the parameters still had instability. All these remind us to find some parameters which can show the details of texture feature preferably, thus perfect the extracted method of texture features in Chinese herbal medicine.

This study was aimed to explore the impact of integrality of Chinese herbal medicine on parameters of tex-ture feature in transverse section images. Three Chinese herbal medicine of Semen Arecae, Radix et Rhizoma Rhei and Radix A tractylodis Macrocephalae with different texture features were taken as research materials. Parts of Chi-nese herbal medicine were cut off from the whole by equal proportions. The 26 parameters were extracted by gray-level co-occurrence matrix and grayscale gradient matrix. The similarities and differences of 26 parameters of texture feature in the parts and whole, rectangular and fan-shaped Chinese herbal medicine were compared. The results showed that parameters of Semen A recae and Radix et Rhizoma Rhei with radial or annular texture had better con-sistency in whole and fan-shaped parts. Parameters of Radix A tractylodis Macrocephalae with irregular texture fea-ture were approximately the same in the whole and rectangular parts. It was concluded that whether parameters of texture features in parts Chinese herbal medicine can present the whole were related to its texture feature and the shape of the parts. This study provided the basis for collection of Chinese herbal medicine when sampling images. It also laid a foundation for the extraction of accurate parameter of texture feature.

This study was aimed to investigate the impact of rotation sampling on feature parameters of texture im-ages of Chinese herbal medicine. Four Chinese herb medicine with various shape and texture feature were taken as research materials. Images of complete and incomplete herbal medicine were collected respectively after different ro-tation angles. The 26 parameters were extracted by gray-level co-occurrence matrix and grayscale gradient matrix. The impact of rotation sampling on feature parameters was investigated through analysis of variation tendency and range of 26 parameters. The results showed that if the Chinese herbal medicine was complete, the 26 parameters were not impacted by the rotation angle, whereas the 26 parameters were impacted by the rotation angle and the im-pact will be more obvious when the shape of Chinese herb medicine was irregular. It was concluded that in order to get a high quality of images and construct a well identification model based on the parameter of texture features, we must consider the impact of rotation angle on the parameters to Chinese herbal medicine with various shapes and tex-ture features.

Digitalization is an important method for the objectification and quantification of quality control on Chi-nese herbal medicine. To solve the problem of texture online visualization of Chinese herbal medicine and the estab-lishment of automatic identification method based on the texture, 12 Chinese herbal medicines were selected to cap-ture the images of their transverse sections. A total of 11 features were extracted from images using Gray-level Co-occurrence Matrix (GLCM) method. Through analyzing the influence of distances and angles between pixels on identi-fication results, it was concluded that when the distance was d = 3 and the angle was ? = 0o, the features extracted were suitable for expressing the texture of the transverse sections. The results indicated the feasibility of establishing the automatic identification method on Chinese herbal medicine based on image of transverse section. It will provide new technologies for the objectification and quantification of identification on Chinese herbal medicine.

Functional analysis concisely summarizes and concentrates on the therapeutic characteristics and features of Chinese herbal medicine. Standardization of the terms for Chinese herbal functions not only plays a key role in modern research and development of Chinese herbal medicine, but also has far-reaching clinical applications. In this paper, a new method for standardizing the terms for Chinese herbal function was proposed. Firstly, functional targets were collected. Secondly, the pathological conditions and the mode of action of every functional target were determined by analyzing the references. Thirdly, the relationships between the pathological condition and the mode of action were determined based on Chinese medicine theory and data. This three-step approach allows for standardization of the terms for Chinese herbal functions. Promoting the standardization of Chinese medicine terms will benefit the overall clinical application of Chinese herbal medicine.

Objective To design a speech command module to replace manual command during X-ray examination.Methods The module was composed of the parts for speech,pushbutton actuator,speaker,miniature voice box,power source and etc.The electrical conductors were used to connect the above parts,and the speech command was formed by special software.Results The module had the speech command triggered by the pushbutton,and the speech command was pellucid and clear so that the workload could be decreased.Conclusion The module facilitates the speech command during X-ray examination,and thus is worthy promoting practically.