Objective To compare laparoscopic with endoscopic procedures in the treatment of gastroesophageal reflux disease(GERD).Methods A retrospective study on 52 cases of laparoscopic Nissen procedure(Laparoscopic Group) and 28 cases of endoscopic gastroplication procedure(Endoscopic Group) was carried out.The patient's general data,operative outcomes,and follow-up results(at 1 and 3 postoperative months) were reviewed. Results The symptoms severity scores and the total reflux time were significantly decreased in both groups.The heartburn index,the regurgitation index,and the reflux time percentile were decreased from 72.2?7.3,1.80?0.45,and 11.2%?6.2% to 14.5?4.8(P