Tendons ; Rupture ; Ultrasonography

Anti-Inflammatory Agents ; therapeutic use ; Betamethasone Valerate ; therapeutic use ; Child, Preschool ; Coloring Agents ; adverse effects ; toxicity ; Dermatitis, Allergic Contact ; diagnosis ; drug therapy ; etiology ; Fusidic Acid ; therapeutic use ; Histamine Antagonists ; therapeutic use ; Humans ; Male ; Parenting ; Phenylenediamines ; adverse effects ; toxicity ; Protein Synthesis Inhibitors ; therapeutic use ; Singapore ; Tattooing ; adverse effects ; Time Factors

Phyllodes tumour is a rare entity, affecting mainly middle aged women. It consists of a spectrum of disease from benign tumour to highly aggressive malignant form. We present a case of massive ruptured malignant Phyllodes tumour, and its subsequent management.

ENL is a type ll leprosy reaction and occurs in people with borderline lepromatous and lepromatous leprosy, usually as a complication following treatment. The treatment of choice for ENL is prednisolone in view of its’ ready availability and affordability1. Howeve r, glucocorticoid therapy, even in low doses, can produce substantial toxicity. The risk is clearly greater as the dose increases. However, in cases where there are steroid-induced complications, high-dosed clofazimine may be used to reduce or withdraw corticosteroids in steroid-dependant cases2,3. We described 2 steroid-dependent ENL patients with steroid-induced complications who are successfully managed with the addition of highdosed clofazimine and the resultant weaning down of systemic glucocorticoids.

Objectives: Although thrombolytic therapy has been shown to be benefi cial to stroke patients, its safety and effectiveness in stroke patients with cardiac tumor is unknown. This study assessed the safety and effi cacy of intravenous thrombolysis with recombinant-tissue plasminogen activator (rtPa) in stroke patients with cardiac myxoma. Methods: We systematically searched databases for all publications on thrombolysis in patients with cardiac tumor-related strokes. The literature on thrombolysis in ischemic stroke patients with myxoma was systematically analyzed; information on the hemorrhagic transformation and response rates in patients over and under 70 years of age was extracted and compared. Statistical tests were performed to evaluate the odds ratios for these factors. Results: Twelve case reports were identifi ed. Four patients were 70 years of age or older, two (50%) of whom had demonstrated hemorrhagic transformation, which was not found in patients under 60 years of age. The rate of response to treatment was 60% (3/5) in patients under 60 and 25% (1/4) in those ≥70 years of age. The rate of hemorrhagic transformation in the patients ≥70 years of age was higher than that in patients <70 years of age (odds ratio 7). Conclusion: Intravenous thrombolysis in ischemic stroke patients with myxoma who were over 70 years of age was associated with a lower response rate and a higher risk of hemorrhagic transformation.

Children with epilepsy are at increased risk of behavioral problems and psychiatric disorders compared with the general population and those with other chronic illnesses. Depression and anxiety disorders are the most common and require further attention because they carry the risk of reduced quality of life and have far reaching consequences in later life. The wide range of prevalence quoted in the literature refl ects methodologic differences. Risk factors are often multifactorial and include illness severity, coexisting morbidity, and psychosocial factors. Diagnosis remains a challenge, as the presentation is heterogenous and age related. This is complicated by epilepsy issues and associated comorbidity that hamper the use of standardized assessment tools. Multimodal treatment involving psychotherapy and antidepressant therapy currently represents the best approach. The mental health needs of these children are largely unmet; increased awareness and better research are required to determine best practices.

There is growing evidence that antiepileptic drugs used in children that are meant to control seizures can actually cause seizure exacerbate instead. To minimize this problem, clinicians should be familiar with the epilepsy syndromes and the appropriate choice of antiepileptic drugs, avoid certain antiepileptic drugs which consistently aggravate specifi c seizure types and maintain a high index of suspicion of those at high risk as seizure exacerbation can present in diverse forms.

Resuscitation is the medical process of reviving a patient in cardiac arrest or impending cardiac arrest. In this paper, we describe some of the resuscitation research conducted by our group. The discussion will include: using Geographic Information Systems (GIS) technology to describe the geographic epidemiology of pre-hospital cardiac arrest in Singapore, therapeutic post resuscitation hypothermia, and automated cardio-pulmonary resuscitation (CPR) using a load-distributing band (LDB) device.
Cardiopulmonary Resuscitation - Education

Helping people to stop smoking is a highly cost-effective and an important means of preventing cardiovascular disease such as ischemic heart disease and stroke. A doctor who fails to provide smoking cessation counselling to a patient who smokes is no better than a doctor who neglects to prescribe a cholesterol – lowering drug. Many smokers want to stop smoking, and others may be receptive to encouragement to stop. As doctors, we are in a unique position to help our patients stop smoking because our advice on health matters is trusted more than anyone else’s (or so we should hope to think). This article was first published in the Singapore Family Physician in 2008, and focuses on what a doctor should do with a patient who smokes. An additional update on alternatives to cigarettes has been added.

Human ; Male ; Adult ; CASE REPORTS ; HYDROCEPHALUS ; ANESTHESIA ; INFANT ; PROPOFOL