Background: Many industrialized countries are witnessing a demographic evolution characterized by the aging of their population. For people over aged 65 year, the prevalence of tooth decay, gum disease and oral cancer is higher than for the general population and higher rates for edentulism (missing teeth), few sound teeth and more filled and decayed teeth than the general population. Risk factors for oral diseases include unhealthy diet, tobacco use, harmful alcohol use, and poor oral hygiene. There is no research work concerning the oral health status of the older population aged 65-74 years old. These age group is selected because they were the adult population groups recommended by the WHO for oral health survey. The purpose of this study was to determine prevalence of caries and edentulous of 65-74 years old and living in the Ulanbator. Methods: An epidemiological survey of 365 older people aged 65-74 was carried out in 2008. It followed the WHO methodology to assessing the oral health status and caries lesions, fi llings, missing teeth were recorded using the WHO criteria. Result: The mean age was 68.70.16. The DMFT index at 65-74 years for the Ulanbator population was 19.50.89 DMFT. Caries prevalence was 52.7% among older people. 4.1% were fully dentate, 21.6% were edentulous, 74.2% were partial edentulism, respectively. Mean number of decayed teeth (DT index) was 3.4, fi lling teeth (FT index) was 2.3, missing teeth (MT index) was 18.0. Conclusion: We carried out this study 365 older people aged 65-74. This preliminary study provide evidence in the direction of building the base of knowledge on prevalence of caries and edentulous elderly person in Ulanbator. The planning and implementation of any strategy for oral health status improvement is crucial alongside the countrys infrastructure development.

Background: There are 13283 people per 100 000 were diagnosed with skin cancer in 2016. Skin cancer is reported not widely in Mongolia. However, melanoma and non-melanoma new case are gradually increasing since 2010. Rhubarb is an old and well-known traditional Mongolian herbal medicine. Rhubarb is rich of bioactive compounds and widely distributed around Mongolia. People are still using Rhubarb as in food consumption and traditional medical treatments. Yet, there is not reported any therapeutic effect of rhubarb based on scientific research.PurposeTo investigate the anti-cancer activities of rhubarb (Rheum undulatum.L), a new herbal preparation from Mongolia, on B16F10 cells Material and Methods: The shoot of rhubarb was soaked with 40% ethanol and methanol. Murine melanoma B16F10 and RAW264.7 macrophage cell lines were purchased from the American Type Culture Collection (ATCC). Cell viability was determined CCK-8 assay. The antimigratory effect of Rhubarb (50-400 μg/μl) was investigated by a wound healing assay for 12 hours. Apoptosis was then evaluated by Western blot analysis. All experiments conducted at Core laboratory of Mongolian national university of medical sciences and Genomics laboratory of Mongolian university of life sciences from November 2015 to February 2017. Results: Ethanol and methanol extract of rhubarb inhibited the proliferation of B16F10 and RAW264.7 cells. In WHMA, cell migration was gradually decreased by concentrate dependent groups compare to the control group. Furthermore, protein expression PARP, Akt, BCL2, BAX and mTOR was investigated. BAX, Akt were down-regulated by rhubarb extraction as expected. DNA fragmentation assay have shown a dose dependent increase in the fragmentation of the DNA signifying apoptotic changes in the R.u extract treated B16F10 cells. Conclusion Rhubarb (Rheum undulatum.L) shows promising anti-cancer activity and can be useful in therapeutic treatment of skin cancer.