1.Health status of khangai mountain regions’ population (30-69 years)
Enkhjargal М ; Tuul M ; Lkhagva L ; Odgerel TS ; Amgalanbaatar D ; Darjaa TS
Mongolian Medical Sciences 2013;166(4):9-14
Backround: Biological age score plays an essential role in the evalution of aging process and health status. The study was focused on clarifying relavance of health status scores of a population of Khangai mountain region with geographical and ecological specifics of the places they live. Goal: To determine the grades of aging (GA) and biological age score (BAS) among population (30-69 years) of Zavkhan aimags.Materials and Methods: We examined 1901 men and women aged 30-69 years old in Zavkhan aimags in 2012 and healthy subjects were assessed with physical, physiological variable. The BAS equation was employed to compute the individual BAScores for all subjects. Quantative data has been processed with the use of statistical data processing software SPSS-19. Results: Health scores of 92.1% of male in the age group of 30-39 years, 68.7% of male in the age group of 40-49 years had health problems (in level IV, V ). In all age groups 70.3% -98.6% had normal adaptation and adaptation functional tension. 54.2- 55.1% of both sex in the ages group 60-69 years had unsatisfactory adaptation.Conclusions: Aging process for women in age groups of 50-59, 60-69 years was significantly delayed or delayed. For men of 30-49 ages aging process was accelerated, for men of 50-69 years it was normal or delayed. Health scores of men in the age group of 30-39, 40-49 years is significantly at a lower level (IV,V) and health scores of women all age groups is significantly at a high level (IIII).
2.The research of logistic regression model and correlations between blood plasma melatonin (MLT) and epidermal growth factor (EGF) with index of skin type of the body, cardiovascular system, biological age and adaptive capacity assessment of relatively healthy people in Uvs province
Buyan-Orshikh S ; Tuya N ; Tsanjidmolom A ; Odgerel TS ; Amgalanbaatar D ; Lkhagva L ; Zevgee T ; Tuul M
Mongolian Medical Sciences 2016;178(4):12-18
BackgroundIn Mongolia scientists have been doing research about skin disease and process of aging. Howeverthere has not enough study material about skin aging process which is the key indicator of aging andhow that affect to Mongolian people.GoalMain purpose is to study correlations between main index of skin type of the body, cardiovascularsystem, biological age, epidermal growth factor and blood plasma melatonin, within the people of Uvsprovincial center as they are relatively healthy people.Material and MethodsResearch works were done using cross sectional study model in years 2015-2016, within randomlychosen 400 citizens of Ulaangom city, counted to be relatively healthy people. Research model includes41 questionnaires, examination and blood plasma samples.Basic indexes of the body, cardiovascular system and respiratory functions were chosen by biomarkers,biological age is determined by V.P.Voytenko’s 4th version method and adaptive capacity assessment isdetermined by R.M.Baevskii’s multi-repeating regression method.Main skin type parameters such as porosity, wrinkles, pigmentation, elastics and aging is determined bythe “BOOMTECH skin diagnosis” digital equipment made in the Republic of Korea.The blood plasma MLT and EGF were measured by the method of ELISA analysis ELISA made in thelaboratory of the “AVITSENNA Science and Technology center”.The study material analysis carried out an analysis using logistic regression analysis and Pearson’scorrelation coefficient with SPSS 23.0 software.ResultThere’s an inverse weak correlation between blood plasma MLT and EGF with body wealth characteristicsof Uvs province citizens. It shows that when the blood plasma MLT and EGF decreases the body weight,body height and body weight index increase tendency.In women the decrease of blood plasma MLT and EGF also decreases the body height and body weightindex.Research on correlation between cardiovascular system and blood plasma MLT and EGF shows thatdecrease of blood plasma MLT causes in increased arterial pressures in both sexual groups, decreasedEGF in women causes decreased arterial pressure.Correlation study between skin main characteristics and blood plasma MLT and EGF shows thatdecreased blood plasma EGF in men resulted in decreased skin wrinkles, porosity, elasticity and skin aging index, in women decreased skin pigmentation and elasticity, and increased skin wrinkles, porosity and aging index in women.Research study of correlation between biological age and adaptive capacity assessment with the blood plasma MLT and EGF shows that decreased MLT and EGF in men results in increased biological age characteristics. In other words, the early aging is caused.The logistical regression analyses made using blood plasma melatonin, skin porosity, biological age,body height and sex as the risk parameters of Pearson coefficient and chi-squared parameter. Above model resulted in skin porosity and blood plasma MLT’s are becoming independent variable assessing the skin aging.Conclusions:1. The decreased MLT and EGF’s are resulted in increased body weight, body height and body weight index in men and decreased body height, body weight index in women.2. Decreased blood plasma MLT resulted in increased arterial pressure in both sexual groups and decreased EGF resulted in decreased arterial pressure in women.3. The decreased blood plasma MLT and EGF results in decreased skin wrinkles, porosity, elasticityand skin aging parameter with the increased skin pigmentation in men, as it results in decreasedskin pigmentation, elasticity and skin porosity parameters with the increased skin aging degree in women.4. When epidermal growth factor and blood plasma melatonin is decreased in men it results in increased biological age, but depends directly to the adaptive capacity assessment.5. Skin porosity and blood plasma melatonin were becoming independent variable to assess skin aging.
3.Study on sarcopenia comparing muscle mass, body mass and height
Bat-Erdene D ; Odgerel Ch ; Erdenekhorol M ; Ganjargal B ; Bayarmagnai L ; Enebish D
Mongolian Medical Sciences 2017;179(1):3-5
Introduction:
Sarcopenia is a prevalent condition characterized by decrease in muscle strength and loss of body
function which result from the decrease of muscle mass in older age. In 2014, the Asian Working Group
for Sarcopenia developed the diagnosis criterion for sarcopenia. The measurements were changed to
accommodate for the physical characteristics of asians. The loss of muscle mass increases after age 40
and decreases by 8 percent every 10 years. After age 70 this number is increased to 15 percent every
10 years.
Goal:
Assess the prevalence of sarcopenia among men by comparing body height and mass
Materials and Methods:
The study included 196 older men aged 40 and above chosen by random sampling from the geriatric and
rehabilitation cabinets of the Mongolian National Gerontology Center.
Sarcopenia diagnosis was made based on the criteria from the Asian Working Group for Sarcopenia
using methods by Janssen I and others to compare body mass and height.
Results:
Comparing body muscle mass and height 11.7 percent of participant aged 40-86 had sarcopenia. When
comparing body muscle mass and weigth 33.2 percent had sarcopenia.
Conclusion
Determining sarcopenia among Mongolian men by comparing muscle mass and body mass resulted in
33.2 percent sarcopenia. When compared with height, 11.7 percent had sarcopenia.
4.Impact of HLA-A-B-DR matching in kidney transplantation: Graft and patient survival in 5-year experiences
Sarantsetseg J ; Oyunbileg B ; Odgerel D ; Narandulam B ; Batbaatar G ; Munkhbat B
Health Laboratory 2019;9(1):5-11
Background:
Kidney transplantation has being performed in Mongolia since 2006. However
there is currently no published data available on long-term graft and patient survival.
Objective:
Our aim was to assess the long-term graft and patient survival rate correlation with HLA-A-B-DR matching.
Methods:
We retrospectively analyzed data from 70 adult kidney transplants performed at
our hospital from August 2006 through January 2014. The data was retrospectively collected
from patient files, including characteristics of the recipient and donor, post transplant features
and HLA-A-B-DR DNA based typing results. The Kaplan-Meier method was used to analyze
graft and patient survival.
Results:
The mean patient follow-up period after kidney transplantation was 39,6±25.9
months, and the mean kidney graft follow-up period was 36.6±23.7 months for 70 cases.
Overall graft and patient survivals were 52 (74.3%) and 60 (85.7%) respectively in 70 cases.
Five-year graft and patient survivals were 23 (67.6%) and 29 (85.3%) respectively in 34
cases. The group with four to six mismatched were found to have a significantly lower 3 and
5-year graft and patient survival (71%; 35%); (80%; 40%) compared to 0 to 1 mismatched
group (100%) (p=.030; p=.015). Furthermore we analyzed the association of HLA matching,
immunosuppressive therapy and long-term graft survival. We selected CNI mono-therapy
group for long-term survival analysis and observed a similar pattern. In mono-therapy group,
the group with four to six mismatched were found to have a significantly lower 3 and 5-year
graft and patient survival (75%; 30%); (65%; 30%) compared to 0 to 1 mismatched group
(100%) (p=.037; p=.001).
Conclusion
The results showed that graft and patient survival rates were lower compared
with results from established centers. Statistically highly significant effect of HLA matching on
kidney graft and patient survival rates was found in our analysis. Five years after
transplantation the graft survival rate of first adult kidney transplant with 4-6MM was 65-70%
lower than that of grafts with 0-1MM. Longitudinal cohort study needed in the future to exhibit
an improved transplantation outcome.