1.Case Report: Severe hypertriglyceridemia in a nondiabetic treated with low dose insulin infusion
Chin Voon Tong ; Shanty Velaiutham ; Nor Azizah Aziz ; Shueh Lin Lim ; Chong Hui Khaw
The Medical Journal of Malaysia 2015;70(4):249-250
We report a case of a 54-year-old man with severe HTG
which did not respond to conventional anti lipid therapies.
He was treated with intravenous insulin and concurrent
dextrose infusions which led to a dramatic reduction in
serum triglyceride levels.
Hypertriglyceridemia
2.A Preliminary Study on the Reliability of the Malay Version of PedsQL™ Family Impact Module among Caregivers of Children with Disabilities in Kelantan, Malaysia
Azriani Ab Rahman ; Norsarwany Mohamad ; Musa Kamarul Imran ; Hans Van Rostenberghe ; Wan Pauzi Wan Ibrahim ; Azizah Othman ; Aniza Abd Aziz ; Sakinah Harith ; Mohd Ismail Ibrahim ; Nor Hashimah Ariffin
Malaysian Journal of Medical Sciences 2011;18(4):63-68
Background: No previous study has assessed the impact of childhood disability on parents and family in the context of Malaysia, and no instrument to measure this impact has previously been available. The objective of this cross-sectional study was to determine the reliability of a Malay version of the PedsQL™ Family Impact Module that measures the impact of children with disabilities (CWD) on their parents and family in a Malaysian context.
Methods: The study was conducted in 2009. The questionnaire was translated forward and backward before it was administered to 44 caregivers of CWD to determine the internal consistency reliability. The test for Cronbach’s alpha was performed.
Results: The internal consistency reliability was good. The Cronbach’s alpha for all domains was above 0.7, ranging from 0.73 to 0.895.
Conclusion: The Malay version of the PedsQL™ Family Impact Module showed evidence of good internal consistency reliability. However, future studies with a larger sample size are necessary before the module can be recommended as a tool to measure the impact of disability on Malay-speaking Malaysian families.
3.Malay Version of Asthma Knowledge Questionnaire: A Validation and Reliability Study
N. Fafwati Faridatul Akmar Mohamad ; Azizah Musa ; Faridah Derani ; Nor Khamizah Mesiran ; Asiah Kassim ; Farizah Mohd Hairi ; Hafizah Zainuddin
Malaysian Journal of Medicine and Health Sciences 2023;19(No.4):3-7
Introduction: The Asthma Knowledge Questionnaire developed by C. Rodriguez Martinez in 2005 was proved to be
a valid instrument for asthma knowledge assessment for parents of children with asthma. 17 items were included in
the questionnaire including their myths and beliefs, knowledge, and associated aspects. The objective of this study is
to analyse the validity and reliability of the Malay version of the questionnaire. Methods: Forward-Backward translation method was used by language experts to obtain the Malay version of the questionnaire. The questionnaire was
then given to twenty respondents at the Paediatric Institute Hospital Kuala Lumpur to ensure the clarity and relevance
of the questionnaire as a pilot study. Subsequently, 60 respondents who fulfilled the inclusion and exclusion criteria
were selected to proceed with the reliability test of the Malay version questionnaire. The results were analysed with
SPSS version 26.0. The reliability and internal consistency were confirmed by intra-class correlation and Cronbach’s
alpha coefficient. Results: There were 60 respondents to the questionnaire consisting of parents and caretaker who
has child with asthma at the Institute of Paediatric Hospital Kuala Lumpur. The mean age of respondents was 34 ±
7.5year old. 91.7% of the respondents were female. The overall Cronbach’s alpha coefficient of the questionnaire
was 0.84. Conclusion: The Malay version of the Asthma Knowledge Questionnaire has a good degree of validity,
reliability and is culturally acceptable equivalent to the original version.
4.Safety and effectiveness of a biosimilar biphasic insulin in the management of diabetes mellitus during routine clinical practice in Asian patients
Zanariah Hussein ; Nor Azizah Aziz ; Dhanaraj E ; Ballari Brahmachari ; Mudgal Kothekar
The Medical Journal of Malaysia 2020;75(4):372-378
Introduction: Biosimilar insulins have the potential to increase
access to treatment among patients with diabetes mellitus
(DM), reduce treatment costs, and expand market competition.
There are no published studies evaluating the performance of
biosimilar insulins in routine clinical practice in Asia. This
study assessed the safety and effectiveness of biphasic isophane
insulin injection in Malaysian DM patients.
Materials and Methods: In this open label, single-arm,
observational, post marketing study, patients received biphasic
isophane insulin injection as per the Prescribing Information;
and were assessed for safety (adverse events including
hypoglycaemia), effectiveness (glycosylated haemoglobin
[HbA1c]; fasting blood sugar, [FBS]; and patient’s condition
by patient and physician) over a period of 24 weeks.
Results: Adult male and female diabetes patients (N=119; type
2 DM, n=117) with a mean (SD) diabetes duration of 13 years
were included. No new safety signals have been identified.
Significant reduction in HbA1c was observed at weeks 12 and
24 (mean [SD] - baseline: 9.6% [1.9]; Week 12: 9.0% [1.7] and
at Week 24: 9.1% [1.7]; p < 0.001). There were 10 serious and 9
non-serious adverse events reported in the study. Expected
mild events included hypoglycaemia and injection site pruritus.
However, the majority of the adverse events were non-study
drug related events. No deaths were reported during the study.
Discussion: Biphasic isophane insulin injection was well
tolerated with no new safety concerns. It was found effective in
post- marketing studies conducted in routine clinical settings
when administered in DM patients in this study.
5.Patient characteristics, disease burden, treatment patterns and outcomes in patients with acromegaly: Real-world evidence from the Malaysian acromegaly registry
Mohamed Badrulnizam Long Bidin ; Abdul Mueed Khan ; Florence Hui Sieng Tan ; Nor Azizah Aziz ; Norhaliza Mohd Ali ; Nor Azmi Kamaruddin ; Shireene Vethakkan ; Balraj Sethi ; Zanariah Hussein
Journal of the ASEAN Federation of Endocrine Societies 2023;38(1):75-80
Objective:
This study aims to report the demographic features of patients with acromegaly the disease burden, and the corresponding treatment patterns and outcomes in Malaysia.
Methodology:
This is a retrospective study that included patients from the Malaysian Acromegaly registry who were diagnosed with acromegaly from 1970 onwards. Data collected included patient demographics, clinical manifestations of acromegaly, biochemical results and imaging findings. Information regarding treatment modalities and their outcomes was also obtained.
Results:
Registry data was collected from 2013 to 2016 and included 140 patients with acromegaly from 12 participating hospitals. Median disease duration was 5.5 years (range 1.0 – 41.0 years). Most patients had macroadenoma (67%), while 15% were diagnosed with microadenoma. Hypertension (49.3%), diabetes (37.1%) and hypopituitarism (27.9%) were the most common co-morbidities for patients with acromegaly. Majority of patients had surgical intervention as primary treatment (65.9%) while 20.7% were treated medically, mainly with dopamine agonists (18.5%). Most patients had inadequate disease control after first-line treatment regardless of treatment modality (79.4%).
Conclusion
This registry study provides epidemiological data on patients with acromegaly in Malaysia and serves as an initial step for further population-based studies.
acromegaly
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treatment outcomes