ObjectiveTo explore the psychological characteristics of personality of the nine constitutions in Traditional Chinese Medicine(TCM),so as to enrich and develop the theory related with constitution in TCM.MethodsFrom May 2009 to June 2009,540 college students from two universities in Beijing were investigated by cross-sectional survey.Cluster sampling method was adopted and the constitution in Chinese Medicine Questionnaire(CCMQ) and Eysenck Personality Questionnaire Short Scale for Chinese (EPQ-RSC) was used.Results ①In extraversion-introversion dimension,Gentleness type had the highest score(56.52 ± 8.48) and Qi-depression type had the lowest score (45.88 ± 11.13 ).The scores of seven pathological constitutions (Qi-deficiency type,Yang-deficiency type,Phlegm-wetness type,Wet-heat type,Blood-stasis type,Qi-depression type and Special diathesis type) were significantly lower than the score of Gentleness type(P＜0.01 ).In neuroticism dimension,Qi-de-pression type had the highest score (59.31 ± 9.70) and Gentleness type had the lowest score (44.08 ± 8.55 ).There were significant differences (P ＜ 0.01 )between the score of Gentleness type and the scores of Qi-deficiency type,Yin-deficiency type,Wet-heat type,Blood-stasis type and Qi-depression type.In psychoticism dimension,there were no significant differences between the score of Gentleness type and the scores of eight pathological constitutions.② Gentleness type was used as control,multivariate logistic regression analysis of psychological characteristics of personality of the eight pathological constitutions showed that the extraversion-introversion dimension was the meaningful relation factor of Qi-deficiency type,Yang-deficiency type,Phlegm-wetness type,Wet-heat type,Blood-stasis type,Qi-depression type and Special diathesis type.The neuroticism dimension was the meaningful relation factor of Qi-deficiency type,Yin-deficiency type,Phlegm-wetness type,Wet-heat type,Blood-stasis type,Qidepression type and Special diathesis type.ConclusionPeople with nine different constitutional types in TCM have shown corresponding psychological characteristics of personality.This study illustrates that nine constitutions in TCM are related to psychological characteristics of personality.

ObjectiveTo explore the relationship between diet habits and constitution type of 8448adults from 9 provinces and municipalities of China.MethodsA total of 8448 participants from Jiangsu,Anhui,Gansu,Qinghai,Fujian,Beijing,Jilin,Jiangxi and Henan Province were enrolled in this study.The clinical information of constitution type,diet habits and demographic characteristics was collected.Logistic regression analysis was used to evaluate the relationship between diet habits and constitution type.ResultsLogistic regression analysis showed that gentleness type and Qi-deficiency were correlated with sweet food ( OR =1.22,P ＜ 0.05 ). There was a significantly positive correlation between Yangdeficiency and hot food intake ( OR =2.89,P ＜ 0.05 ),as well as between Yin-deficiency and cold food intake ( OR =1.56,P ＜ 0.05).Phlegm-wetness was mainly caused by fatty food consumption ( OR =2.07,P ＜ 0.05 ).Barbecue food was positively correlated with Wet-heat type ( OR =1.64,P ＜ 0.05 ),Bloodstasis type ( OR =1.37,P ＜ 0.05 ),and Qi-depression type ( OR =1.35,P ＜ 0.05 ).Special diathesis type was related to dietary preference of sweet food ( OR =1.29,P ＜ 0.05 ).ConclusionDifferent type of constitution may be related to specific lifestyle or diet habits,and diet habit might play a positive role in Gentleness type or health condition.

Objective To compare the clinical effects and safety of treating newly diagnosed type 2 diabetes patients by combining Glargine insulin with Metformin or/and Acarbose. Methods 84 patients with newly diagnosed type 2 diabetes ,who have a history of weight loss, body mass index( BMI )23 ～ 28kg/m2 and poorly controlled blood glucose in Metformin at least a month ,were randomly divided into three groups. Glargine insulin plus Mefformin were used in group A. Glargine insulin plus Acarbose(without mefformin)were used in group B, Glargine insulin, Acarbos and metformin were used in Group C. All three groups were given a 12-week follow-up. Results FBG,2hBG and HbA1c levels were lower in the patients after treatment( P ＜0. 05 ). HbA1c of patients was partly up to the standard in group A and group B,but HbA1c of patients was all up to the standard in group C. The effects in group C were better than those in group A and group B. It had the shortest time to achieve the target and the smallest dose of insulin in group C. BMI in group A and B did not change but decreased in group C(P＞0.05).The incidence of low blood sugar in all three groups was low and no significant difference observed among three groups (P＞0.05). And in all three groups no severe hypoglycemia occurred. Conclusion The method of combining Glargine insulin with Mefformin or/and Acarbose could effectively control blood sugar had little impact on body weight of the newly diagnosed type 2 diabetes patients, and moreover, the incidence of low blood sugar in the newly diagnosed type 2 diabetes patients was lower. It would be the ideal method to treat newly diagnosed type 2 diabetes patients considering the general safety and effectiveness and convenience.

OBJECTIVE: To investigate the variations in the expression of voltage-gated sodium (Na_v) channel subunits during development of rat cerebellar Purkinje neurons and their correlation with maturation of electrophysiological characteristics of the neurons. METHODS: We observed the changes in the expression levels of Na_V1.1, 1.2, 1.3 and 1.6 during the development of Purkinje neurons using immunohistochemistry in neonatal (5-7 days after birth), juvenile (12-14 days), adolescent (21-24 days), and adult (42-60 days) SD rats. Using whole-cell patch-clamp technique, we recorded the spontaneous electrical activity of the neurons in ex vivo brain slices of rats of different ages to analyze the changes of electrophysiological characteristics of these neurons during development. RESULTS: The expression of Na_V subunits in rat cerebellar Purkinje neurons showed significant variations during development. Na_V1.1 subunit was highly expressed throughout the developmental stages and increased progressively with age (P < 0.05). Na_V1.2 expression was not detected in the neurons in any of the developmental stages (P > 0.05). The expression level of Na_V1.3 decreased with development and became undetectable after adolescence (P < 0.05). Na_V1.6 expression was not detected during infancy, but increased with further development (P < 0.05). Na_V1.1 and Na_V1.3 were mainly expressed in the early stages of development. With the maturation of the rats, Na_V1.3 expression disappeared and Na_V1.6 expression increased in the neurons. Na_V1.1 and Na_V1.6 were mainly expressed after adolescence. The total Na_V protein level increased gradually with development (P < 0.05) and tended to stabilize after adolescence. The spontaneous frequency and excitability of the Purkinje neurons increased gradually with development and reached the mature levels in adolescence. The developmental expression of Na_V subunits was positively correlated with discharge frequency (r=0.9942, P < 0.05) and negatively correlated with the excitatory threshold of the neurons (r=0.9891, P < 0.05). CONCLUSION The changes in the expression levels of Na_V subunits are correlated with the maturation of high frequency electrophysiological properties of the neurons, suggesting thatmature Na_V subunit expressions is the basis of maturation of electrophysiological characteristics of the neurons.
Rats ; Animals ; Purkinje Cells/physiology* ; Rats, Sprague-Dawley ; Neurons ; Brain ; Sodium/metabolism*