1.Design of a closed-loop automatic mechanical ventilation controller
Huimin DUAN ; Aihua CHEN ; Ningbo ZHAN
China Medical Equipment 2014;(11):43-45,46
Objective:In the clinical mechanical ventilation practice, the medical workers often set the ventilator parameters only depend on their own experience. In order to change that,we design a Closed-Loop Automatic Mechanical Ventilation Controller.Methods: Design two closed-loop control subsystems to meet the requirements of closed-loop control system. PETCO2 control subsystem used to keep the concentration of PETCO2, and another subsystem design to regulate the respiratory elasticity called PEEP control subsystem. PETCO2 control subsystem can work on its own or work with PEEP control subsystem.Results: Using this closed-loop controller, the partial CO2 pressure and respiratory elasticity of patient was regulated in real time.Conclusion:By using this closed-loop automatic mechanical ventilation controller, the respiratory elasticity was largely reduced with the adequate gas exchange. Therefore, the ventilator using this closed-loop automatic mechanical ventilation controller can improve the ventilation quality and also reduce the risk of lung injury.
2.CREB-regulated transcription coactivator 1: important roles in neurodegenerative disorders.
Zhan-Cheng XUE ; Chuang WANG ; Qin-Wen WANG ; Jun-Fang ZHANG
Acta Physiologica Sinica 2015;67(2):155-162
The cAMP-responsive element binding protein (CREB)-regulated transcription coactivator, CRTC (also known as transducer of regulated CREB, TORC), is identified as a potent modulator of cAMP response element (CRE)-driven gene transcription. The CRTC family consists of three members (CRTC1-3), among which the CRTC1 shows the highest expression in the brain. Several studies have demonstrated that the CRTC1 plays critical roles in neuronal dendritic growth, long-term synaptic plasticity, memory consolidation and reconsolidation etc., whereas dysfunction of CRTC1 is mainly involved in neurodegenerative disorders. In light of these findings, we aim to review recent research reports that indicate the CRTC1 dysfunction and its underlying mechanisms in the neurodegenerative disorders.
Brain
;
physiology
;
Dendrites
;
physiology
;
Humans
;
Neurodegenerative Diseases
;
physiopathology
;
Neuronal Plasticity
;
Transcription Factors
;
physiology
3.Closed-loop control for chest compression based on coronary perfusion pressure: a computer simulation study.
Aihua CHEN ; Lei GAO ; Linhuai TIAN ; Jian ZHANG ; Ningbo ZHAN
Journal of Biomedical Engineering 2014;31(4):910-934
In this study, a closed-loop controller for chest compression which adjusts chest compression depth according to the coronary perfusion pressure (CPP) was proposed. An effective and personalized chest compression method for automatic mechanical compression devices was provided, and the traditional and uniform chest compression standard neglecting individual difference was improved. This study rebuilds Charles F. Babbs human circulation model with CPP simulation module and proposes a closed-loop controller based on a fuzzy control algorithm. The performance of the fuzzy controller was evaluated and compared to that of a traditional PID controller in computer simulation studies. The simulation results demonstrated that the fuzzy closed-loop controller produced shorter regulation time, fewer oscillations and smaller overshoot than those of the traditional PID controller and outperforms the traditional PID controller in CPP regulation and maintenance.
Algorithms
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Arterial Pressure
;
Cardiopulmonary Resuscitation
;
instrumentation
;
Computer Simulation
;
Coronary Vessels
;
physiopathology
;
Humans
;
Models, Theoretical
;
Perfusion
;
Thorax
4.Arthroscopic treatment for the calcific tendinitis at soft tissues around hip.
Ying-Chun ZHU ; Xue-Wen JIA ; Yun-Feng MI ; Zhan-Ping JIN ; Wen-Ji SHI ; Cui WANG ; Ji-Hong ZHANG
China Journal of Orthopaedics and Traumatology 2021;34(7):659-664
OBJECTIVE:
To explore the feasibility and clinical effects of arthroscopic treatment for the calcific tendinitis at soft tissues around hip.
METHODS:
A total of 16 patients diagnosed as the calcific tendinitis at soft tissues around hip from May 2013 to July 2018 were retrospectively analyzed. All the 16 patients received arthroscopic procedures. There were 10 males and 6 females with an average age of 35 to 63 (44.50±6.67) years old and 9 left hips, 6 right hips were involved. The course of disease were 1 to 8(3.18±1.97) days. Clinical effects were evaluated with visual analogue scale(VAS), modified Harris hip scores (HHS), nonarthritic hip score (NAHS) and imaging examinations before operation, 1 day after operation and the final follow-up.
RESULTS:
All 16 patients successfully finished the arthroscopic procedures in 0.5 to 1.2 (0.75±0.21) hours. Primary healing of incision were obtained without any complications of infection, wound hematocele and neurovascular injury. All 16 patients received an average postoperative follow-up of 6 to 12 (9.6±2.3) months. Before operation, the VAS were 7.88±0.72, modified HHS were 29.25±3.23, NAHS were 27.42±3.08. The 1st day postoperative VAS were 2.19±0.66, modified HHS were 82.56± 5.64, NAHS were 82.11±2.94, all the difference were statistically significant between before and 1 day after operation (
CONCLUSION
Arthroscopic treatment for the calcific tendinitis at soft tissues around hip is effective.It has advantages of minimal invasive, rapid pain relief, rapid hip joint function recovery and definite clinical effects.
Adult
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Arthroscopy
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Female
;
Follow-Up Studies
;
Hip/surgery*
;
Hip Joint/surgery*
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Humans
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Male
;
Middle Aged
;
Retrospective Studies
;
Tendinopathy/surgery*
;
Treatment Outcome
5.Prospective cases-control study on arthroscopic for the treatment of ischial tuberosity cyst.
Ying-Chun ZHU ; Xue-Wen JIA ; Zhe-Yang WANG ; Cui WANG ; Zhan-Ping JIN
China Journal of Orthopaedics and Traumatology 2018;31(3):217-221
OBJECTIVETo compare technique and clinical effect of arthroscopic and conventional sectional therapy for the treatment of ischial tuberosity cyst.
METHODSFrom May 2014 and September 2016, 49 patients with symptomatic ischial tuberosity cyst were randomized divided into arthroscopic group and conventional section group by envelope method. There were 24 patients in arthroscopic group, including 16 males and 8 females aged from 42 to 81years old with an average age of (64.1±9.3) years old;the courses of disease ranged from 2 to 36 months with an average of (17.0±9.1) months;treated with removing cyst wall under arthroscopic and build artificial lacuna around cyst. There were 25 patients in conventional section group, including 11 males and 14 females aged from 47 to 79 years old with an average of (61.2±10.6) years old; the courses of disease ranged from 4 to 36 months with an average of (17.5±8.5) months;treated with cutting off lump with transverse incision. Operative time, blood loss, fluid volume, hospital stays and postoperative complication were observed and compared, VAS score were applied to evaluate pain degree.
RESULTSForty-nine patients were followed up from 6 to 18 months with an average of (11.3±3.3) months. In conventional group, 2 patients occurred incision infection, 1 case reoccurred. All patients in arthroscopic group were healed at stage I. Operative time, blood loss, fluid volume, and hospital stays in arthroscopic group were (54.7±7.7) min, (20.8±3.5) ml, (20.3±5.6) ml, (2.8±0.6) d respectively and better than that of conventional group(71.8±8.8) min, (67.3±12.0) ml, (103.6±20.3) ml, (7.8±2.9) d. Postoperative VAS score in arthroscopic group on the first day, seventh days and first month were 2.6±0.7, 0.5±0.6, 0.3±0.5, and significantly lower than that of conventional group 6.0±0.7, 3.0±1.0, 1.1±1.0 respectively(<0.05). There were no statistical difference in postoperative complications between two groups(>0.05).
CONCLUSIONSCompared with conventional group, arthroscopic for ischial tuberosity cyst has advantages of minimal invasive, less blood loss during perioperative period, less pain degree after surgery, safety and rapid recovery. But arthroscopic skills are needed for surgeons. It should be recommended in clinical practice.
Adult ; Aged ; Aged, 80 and over ; Arthroscopy ; Bone Cysts ; surgery ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Operative Time ; Pelvic Bones ; pathology ; Postoperative Period ; Prospective Studies ; Treatment Outcome
6.Clinical application of acromion radiological classification in diagnosis and treatment of rotator cuff injury.
Ying-Chun ZHU ; Xue-Wen JIA ; Yun-Feng MI ; Yu-Feng ZHU ; Zhan-Ping JIN ; Dong-Dong XIA ; Chun-Xiao GU ; Ji-Hong ZHANG ; Cui WANG
China Journal of Orthopaedics and Traumatology 2022;35(8):757-762
OBJECTIVE:
To develop a new classification of acromion based on the subacromial impingement theory and the Rockwood tilt view. And explore the application value of the new classification in the diagnosis and treatment of rotator cuff tear.
METHODS:
The clinical data of 101 patients underwent shoulder arthroscopic surgery for impingement syndrome or rotator cuff tear from January to December 2017 were retrospectively analyzed. There were 34 males and 67 females, aged from 34 to 76 years with an average of (56.31±9.63) years old, course of disease from 2 to 12 months with average of 6 months. Preoperative radiographs of the routine anteroposterior view, Rockwood tilt view and the supraspinatus outlet view were obtained. Based on the subacromial impingement theory and Rockwood radiographs, the morphology of the acromion can be divided into three types:typeⅠ(flat type), typeⅡ(bump type), and type Ⅲ (impingement type). Two observers classified 101 shoulder Rockwood radiographs according to the new classification method and the supraspinatus Outlet radiographs according to the traditional acromial morphological classification method. Supraspinatus tendon injuries were classified into no tear, partial-thickness tear, and full-thickness tear according to the arthroscopic findings. Concordance test (Kappa value) between the inter-observer and intra-observer was carried out for the new classification method and the traditional classification method respectively. The rank sum test was used to compare the mean acromiohumeral distance(AHD) of the three acromion forms in the new acromion classification method. Spearman rank correlation test and Gamma method were used to analyze the correlation between the new acromion classification method and the degree of supraspinatus tendon tear.
RESULTS:
The inter-observer consistency analysis of the new classification system was significantly better than that of the traditional classification (0.827 vs 0.278), the intra-observer consistency analysis of the new classification system were also significantly better than that of the traditional classification (0.921 vs 0.448, 0.890 vs 0.539). There was no statistical significance in the AHD among three types of the new classification(H=2.186, P>0.05). In all 101 patients, the highest proportion of impingement type acromion was 45.5% (46 cases), followed by bump type acromion was 36.6% (37 cases), and flat type acromion was 17.8% (18 cases). The incidence of supraspinatus tendon tear in the patients with impingement type acromion was significantly higher than that of the other two types of acromion, there was a spearman rank correlation between the new acromion type and the degree of the supraspinatus tendon tear(rs=0.719, P<0.001).
CONCLUSION
Rockwood radiographs of the shoulder can well display the anterolateral osteophytes of the acromion. The new acromion classification method based on Rockwood radiographs has high reliability and good reproducibility, in which impingement type of acromion is closely related to supraspinatus tendon tear. Compared with the traditional classification and AHD, the new classification method has more diagnostic value than for rotator cuff injury.
Acromion/surgery*
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Aged
;
Female
;
Humans
;
Magnetic Resonance Imaging/methods*
;
Male
;
Middle Aged
;
Reproducibility of Results
;
Retrospective Studies
;
Rotator Cuff/surgery*
;
Rotator Cuff Injuries/surgery*
;
Rupture
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Shoulder Impingement Syndrome/surgery*
7. A preliminary study on prediction efficacy of multimodal MRI-based radiomics in combination with random forest model for preoperative glioma IDH1 gene type expression
Wenting LAN ; Zhan FENG ; Yan ZHANG ; Zhenya ZHAO ; Yi HUANG ; Qiuli HUANG ; Yuning PAN
Chinese Journal of Radiology 2019;53(10):864-870
Objective:
To preliminarily analyze the prediction efficiency of multimodal MRI-based radiomics model for preoperative glioma IDH1 gene expression type.
Methods:
The MRI data of 108 surgery-proven glioma patients from May 2015 to January 2019 were retrospectively analyzed, and the MRI data included axial T1WI,T2WI,fluid attenuated inversion recovery (FLAIR),DWI imaging and enhanced T1WI sequence.Forty-seven cases were IDH1 mutant type, and 61 cases were IDH1 wild type. All patients were divided into training and validation groups according to the 7∶3 ratio of the random forest model. Seventy-three cases were in training group, and 35 cases were in validation group. Independent predictors of IDH1 mutation were screened by univariate analysis combined with multivariate logistic regression analysis (
8.Pure spinal epidural cavernous hemangioma: report of one case.
Zhan HE ; Fang DING ; Jian-dong RONG ; Guang-yao ZHU
Journal of Zhejiang University. Medical sciences 2015;44(2):233-235
A 55-year-old man presented with progressive numbness and weakness of both lower limbs is reported. MRI demonstrated a pure epidural lesion at T3-6 space appearing as isointense on T1-weighted images with enhancement by contrast medium and hyperintense on T2-weighted images. The lesion was totally removed microsurgically. Histological examination revealed cavernous hemangioma. The patient made a good recovery after surgery.
Epidural Space
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Hemangioma, Cavernous
;
diagnosis
;
Humans
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Magnetic Resonance Imaging
;
Male
;
Middle Aged
;
Spine
;
pathology
9.Single scrotal-incision orchidopexy without ligation of processus vaginalis for palpable undescended testis.
Yi CHEN ; Jun-Feng ZHAO ; Fu-Ran WANG ; Yan LI ; Zhan SHI ; Hong-Ji ZHONG ; Jian-Ming ZHU
National Journal of Andrology 2017;23(8):708-712
Objective:
To determine the feasibility and short-term effect of single scrotal-incision orchidopexy (SSIO) without ligation of the processus vaginalis (PV) in the treatment of palpable undescended testis (PUDT).
METHODS:
This retrospective study included 109 cases of PUDT (125 sides) and 15 cases of impalpable undescended testis (IUDT). The former underwent SSIO without PV ligation (group A, n = 53) or standard inguinal orchidopexy with PV ligation (group B, n = 56) while the latter received laparoscopic exploration (group C). We analyzed the success rate of SSIO in the management of PUDT, postoperative complications, and incidence rates of hernia and hydrocele, and compared the relevant parameters between groups A and B.
RESULTS:
The median age of the PUDT patients was 1.4 (0.6-11.0) years. Group A included 24 cases of left PUDT (2 with hydrocele), 20 cases of right PUDT (1 with hydrocele), and 9 cases of bilateral PUDT, the success rate of which was 95.1%. Group B consisted of 27 cases of left PUDT, 22 cases of right PUDT (3 with hernias), and 7 cases of bilateral PUDT. The rate of PV patency in the PUDT patients was 80.8% (101/125). Laparoscopic exploration of the 15 IUDT patients revealed 2 cases of congenital testis absence, 6 cases of testis dysplasia, all treated by surgical removal, 3 cases of staying around the inner ring, descended by inguinal orchidopexy, and the other 4 treated by laparoscopic surgery. The incisions healed well in all cases, with no testicular atrophy, inguinal hernia or hydrocele.
CONCLUSIONS
Single scrotal-incision orchidopexy without PV ligation is a safe and feasible procedure for the treatment of palpable undescended testis, which avoids the risk of inguinal hernia or hydrocele.
Child
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Child, Preschool
;
Cryptorchidism
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surgery
;
Feasibility Studies
;
Gonadal Dysgenesis, 46,XY
;
diagnosis
;
Hernia, Inguinal
;
Humans
;
Infant
;
Laparoscopy
;
statistics & numerical data
;
Ligation
;
statistics & numerical data
;
Male
;
Orchiopexy
;
adverse effects
;
methods
;
Postoperative Complications
;
etiology
;
Retrospective Studies
;
Scrotum
;
surgery
;
Surgical Wound
;
Testicular Diseases
;
diagnosis
;
Testicular Hydrocele
;
Testis
;
abnormalities
10.A case of idiopathic hypertrophic cranial pachymeningitis presenting as chronic subdural hematoma.
Zhan HE ; Fang DING ; Jiandong RONG ; Yongli GAN
Journal of Zhejiang University. Medical sciences 2016;45(5):540-543
A 26-year-old male presented with a 6-day history of paroxysmal headache which was worsen with nausea and vomiting for 1 day. Head CT on admission revealed left chronic subdural hematoma with midline shift. An emergency Burr hole drainage for hematoma was performed. Headache recurred 6 days later. MRI of the brain revealed a diffuse thickening and a gadolinium-enhancement of the falx, cranial dura mater and tentorium cerebelli on the left side with pia mater involved. Lumber puncture showed increased intracranial pressure and elevated IgG level in cerebrospinal fluid. Histological examination of the biopsy specimen showed thickened, fibrotic dura with a sterile chronic inflammation. According to pathological examination, idiopathic hypertrophic cranial pachymeningitis was considered as the final diagnosis. Symptoms were improved with steroid pulse therapy.
Adult
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Biopsy
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Brain
;
pathology
;
Drainage
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Dura Mater
;
pathology
;
Hematoma, Subdural, Chronic
;
etiology
;
surgery
;
Humans
;
Hypertrophy
;
diagnosis
;
Immunoglobulin G
;
cerebrospinal fluid
;
Intracranial Hypertension
;
etiology
;
Magnetic Resonance Imaging
;
Male
;
Meningitis
;
diagnosis
;
Steroids
;
administration & dosage
;
therapeutic use
;
Tomography, X-Ray Computed