Objective To analyze CT images and clinical manifestation of cerebral infarction and discuss diagnostic value to improve early diagnosis. Methods 124 cerebral infarction cases which have suffered in our hospital were researched. Results The shapes of ischemic infarct were round, oval and streak, but the shapes of temporal lobe focus were mostly lamellar irregular, low density and little occupying-effect. Hemorrhagic infarcts of forehead and parietal lobe were fanlike or irregular and low density area with mottling high density. Conclusion Cerebral arterial thrombosis was relative closely to hypertension and diabetes mellitus. The cerebral infarctions almost occur in basal ganglia. Lobe of brain, cerebellum and brainstem is key part so that explains basal ganglia of penetrating branch cerebral arteries were high site of ischemic cerebral artery disease Mutilation rate and mortality may be reduced by CT examine in time and linked to clinical thrombolysis and intervention treatment.

The recent report "The Consensus Coding Sequences of Human Breast and Colorectal Cancers"published in Science represents the first unbiased systematic mutational analysis of human genome at any disease states after the completion of The Human Genome Project. It was tentatively discussed how to take advantage of the candidate cancer genes found in this study in discovery of novel targets of therapeutic drugs. In addition, the penitential values of the candidate cancer genes in identification of patients at high risk of cancer, and in renewing classification of tumors based on underlying molecular mechanisms are introduced.

Readiness for hospital discharge is an important measure to ensure the safety of patient discharge. Evaluating the readiness for hospital discharge can help medical staff to avoid premature discharge of patients and to reduce the incidence of complications and readmission rate. This paper reviews the concept, content and tools of assessment, and the research interests and fields of discharge readiness, so as to provide help and support for further research.

Objective To investigate the effects of estrogen on extracellular signal-regulated kinase-1/2(ERK1/2) phosphorylation levels in hippocampal CA4 region of ovariectomized rats. Methods Experimental female Wistar rats were randomly divided into three groups: intact (INT) group, ovariectomized (OVX) group, and OVX+estrogen (1 mg/kg, weekly) group. Radioimmunoassay (RIA) was used to measure the estrogen content in plasma, and the levels of ERK1/2 phosphorylation were measured with immunohistochemistry. Results Compared with the control animals, the plasma estrogen level was significantly lower in OVX group (P＜0.001). However, the plasma estrogen level was higher in the OVX+estrogen group than that of the OVX group (P＜0.001). Immunohistochemical staining showed that the phospho-ERK1/2 (p-ERK1/2) substances were present in the nucleus and cytosol of neurons. Compared with the control group, immunostaining positive cells markedly decreased in OVX group, with light nucleus and cytosol staining in the hippocampal CA4 region (P＜0.001). The phospho-ERK1/2 positive neurons increased more obviously in OVX+estrogen group than in the OVX group (P＜0.001). Conclusion Estrogen can increase ERK1/2 phosphorylation levels in hippocampi of aging female rats, which suggests that the ERK signal transduction pathway may be regulated by estrogen during the process of aging.

WHO has issued three editions of pathologic classification of bladder urothelial carcinoma in 1973,1999 and 2004.The 1973 version classification had been widely and the longest applied.However,WHO 2004 classification had been prevalent in past years.There were two issues in the applications of WHO 2004 classification.On one hand,there were some difficulties in quick grading in a given case.On the other hand,there were some misunderstandings in the conversion of different WHO classification.In this article,the changes of different pathologic classification of bladder urothelial carcinoma were reviewed and the outline of different pathologic classification was generalized.The criterion of all the systems was cell anaplasia.In WHO 1973 version classification,the definition of the various grades was vague.It was relatively precise in WHO 1999 classification.However,the grading of Ⅰ,Ⅱ and Ⅲ in WHO 1999 classification still remained confusions.The major changes in WHO 2004 classification was that this system divided urothelial carcinoma into low-and high-grade,which may solve the heterogenesis of grade Ⅱ in the other two classifications.

Adult ; Coal Mining ; Cognition Disorders ; etiology ; Explosions ; Follow-Up Studies ; Humans ; Surveys and Questionnaires ; Survivors ; Young Adult

Objective: To discuss the clinical effect of the treatment of metaphyseal cancellous bone fracture with fragment fixation system implants(FFS).Methods:Thirty patients treated with FFS were reviewed.Results:The patients were followed up for 7～　24 months (8.7 months in average).The fractures in all cases were healed in 6 months and the function recovered or nearly reeovered. Conclusion:By traction with FFS to treat this kind of fracture,the fractures and joint function recovered.The operation is simple and trauma is little.

Withaferin compounds have attracted increasing attention in nervous system disorders in reecnt years, which has been reported to have excellent neuroprotective role in stroke, spinal cord injury, ncuroinflammation and so on. The effects of withaferin compounds for nervous system disorders are mainly summa rized in this research, including relevant reports and our recent works.

Objective To evaluate the risk urodynamic factors of upper urinary tract deterioration in children with neurogenic bladder dysfunction secondary to myelodysplasia. Methods Urodynamic and imaging studies were performed in 32 children with myelodysplasia. Results 18 patients had ureterohydronephrosis and 4 of them had vesicoureteric reflux.Of 19 children with detrusor leak point pressure higher than 40 cmH 2O and bladder compliance less than 40ml/cmH 2O, upper tract deterioration was revealed in 17.In contrast,of 13 patients with detrusor leak point pressure less than 40 cmH 2O and bladder compliance higher than 40 ml/cmH 2O, only one had bilateral ureteral dilatation( P

[Objective]To explore the clinical characteristic of combined posterior cruciate ligament (PCL) with posterolateral corner (PLC) injuries,and evaluate the technique and outcome of arthroscopic single bundle reconstruction of PCL and reconstruction of PLC with posterior half of biceps femoris tendon.[Method]From Dec. 2001 to Dec. 2004,14 patients (14 knees) with severe posterior and posterolateral rotatory instability were treated surgically in our department,all of them presented III degree positive results of posterior drawer test,positive varus stress test and more than 10 degree of external rotation of the affected knees compared with the intact knees.PCL tear and abnormal opening of posterolateral compartment were seen in all of the 14 knees under arthroscopy.Of them,2 knee were combined with common peroneal nerve injury.All the damaged PCLs were reconstructed with single bundle of autogenous quadrupled hamstring tendons under arthroscopy,and PLCs were reconstructed with the posterior half of biceps femoris tendon tenodesis.[Result]No severe complications occurred in early stage after operation in the 14 patients.All of them were followed up from 12 to 33 months with an average of 21.14?7.26 months.Posterior stabilities were recovered significantly,varus stress test was negative at 30 degree of flexion and full extension,less than 10 degree of external rotation compared with the intact knee in all of the patients.Lysholm score was remarkable improved from 40~60 (mean 47.1?8.25) preoperatively to 70~95 ( mean 86.79?7.23) at follow up(P