The modest pressure promotes the graduate to keep continuous energy and focus on scientific research,but too much pressure will lead to mental problem and serious moral shortcoming.Reformation of scientific evaluating and promoting system,enhancement of scientific interest and reconstruction of mental training system should be the important ways to release the pressure of scientific research of the graduate.

Objective:To explore the clinical therapeutic efficacy and the best way of nutritional support and period in patients with severe head injury.Methods:128 patients with severe head injury were divided into internal nutrition group(ENG) and parenteral nutrition group(PNG)at random.Treated by emergent operations and 48 hours later,all the patients received the rationed nitrogen and calorie,containing nutritional support via different pathway.At the same time,we had been monitoring the nutrional indexes,the metabolic indexes,the complications of nutritional support and calculating the nutritional costs during the whole treatment.Results:The nutritional indexes were effectively maintained in both ENG and PNG,but the metabolic indexes,the complications of nutritional support and the nutritional cost of the PNG rose more obviously than those of ENG.Conclusion:Early postoperative EN and PN nutritional support could improve the nutritional status of the patient.EN had much benefit,including comprehensive nutrition,safety,convenience and low costs.It should be the first pathway for mutritional support.

Objective:To evaluate the curative efficacy,clinical benefit response (CBR),survival length and toxicity of radiochemotherapy combined with 24 hours continuous infusional gemcitabine for locally advanced unresectable pancreatic adenocarcinoma.Methods:20 patients with histologically or cytologically confirmed locally advanced unresectable pancreatic adenocarcinoma were enrolled into this trial,all of whom had bidimensionally measurable disease that could be assessed by radiographic procedures.Gemcitabine was administered as a 24 hours continuous infusion once weekly for 3 of 4 weeks.Radiation therapy was 3 dimensional conformal radiation therapy (3DCRT),using megavolt irradiation(total dose,45Gy,1.8/Gy/day) of 6MV photons or greater with a 3 or 4-field technique which was delivered concurrently for 5 weeks.Results:Only 2 partial response was observed(10%),and disease was stabilized in 13 additional patients(65%).The median time to progression was 6.5 months (range, 2～13 months).Although all patients developed distant metastases,locoregional failure occurred in only 4.The median survival time was 9.6months (range,3～23.0~+months),and 1-year survival rate was 14.3%.Positive CBR was 14/17(82.4%).The main side effects included slight liver function damage and neutropenia,thrombocytopenia,hypochromia.Conclusion:Gemcitabine when given as prolonged infusion in 130mg/m~2/week combined with 3DCRT is feasible and effective for local control of pancreatic cancer and CBR,but essentially ineffective in counteracting metastatic tumor growth.

Objective: By hybrid technology,to study the biological characteristics and antitumor function of gastric cancer-dendritic fusion cells through the fusion of dendritic cells from cord blood with gastric cancer cells SGC7901,Method: DCs from cord blood were fused with SGC7901 in the presence of 50% polyethylene glycol.The morphology and phenotype of DCs,SGC7901 and DCs/SGC7901 were respectively observed by SP immunocytechemical staining.The ability of DCs/SGC7901 which stimulated proliferation of autologous T lymphocytes was assessed by MTT,and the kill rate of cytotoxic T lymphocytes(CTL) to SGC7901 induced by FCs(fusion cells) was evaluated through cytotoxic test.Result: DCs were successfully fused with SGC7901 in the presence of PEG,FCs expressed CEA and HLA-DR two phenotypes.Moreover,fusion cells had greater ability to stimulate proliferation of T lymphocytes than DCs?DCs+SGC7901,SGC7901,and the kill rate of FCs(21.4%?0.0165%) was greatty high than that of DCs(16.3%?0.0015%),DCs+SGC7901(15.3%?0.0044%),SGC7901(11.2%?0.0156%).Conclusion: DCs from cord blood can be successfully fused with SGC7901 in the presence of PEG,and FCs can effectively stimulate T lymphocytes to elicit antitumor immunity effect.

0.05.In Group B,the inducing rate was 81.8 %(9/11) before intervention,while post intervention the rate was 9.1 %(1/11),the difference of inducing rate pro and post intervention was statistically significant at P0.05 before intervention,the difference was significant at P

Objective:To evaluate the efficacy and safety of rifaximin against acute bacterial diarrhea.Methods:The effect of rifaximin for the treatment of acute bacterial diarrhea was investigated in a randomized,single-blind clinical trial with control of ciprofloxacin.Patients were administered with rifaximin 0.4g tid on the first day,followed by 0.4g bid;as for ciprofloxacin 0.25g tid on the first day,followed by 0.25g bid,until the end of 3～7days treatment,respectively.Stool,blood(hepatic and renal functions),urine samples and ECG of pre-and post-treatment were assayed for safety evaluation of rifaximin in diarrhea patients.Results:29 patients in rifaximin group and 25 in ciprofloxacin group showed similar efficacy rates and recovery rates, 100% and 91.3% respectively.There was no statistic difference between the two groups related to the effectiveness.The bacterium positive rate was 64.8%(35/54)before treatment.Bacterial clearance rates were 100% and 87.5%.No statistic difference and obvious side effect in the two groups were observed.Conclusion:rifaximin is safe and effective in the treatment of acute bacterial diarrhea.

Taking the Fourth Affiliated Hospital of China Medical University as an example,the information integration platform of the hospital is constructed in accordance with the national data and information interaction standard and HL7 standard.The paper introduces the idea for selecting platform products,and technical route and effect of platform construction,and provides guarantee for sustainable development of the hospital,in order to greatly improve core competitiveness of the hospital.

AIM: To establish a new method for quick identifying Shuanghuanglian Oral Liquid(Flos Lonicerae japonicae,Radix Scutella riae,Fructus Forsythiae) by AOTF-Near infrared spectroscopy. METHODS: Near infrared spectroscopy combined with principal component analysis. RESULTS: The model SHL-C of Shuanghuanglian Oral Liquid could distinguish Shuanghuanglian Oral Liquid from Yinhuang Oral Liquid and other 9 kinds of these(oral) liquids. CONCLUSION: The method is quick,simple and low cost assay technique and can be used to identification of Shnanghuanglian Oral Liquid.

Objective:To investigate the effects on the activity of acetylcholinesterase (AchE) and choline acetylase(ChAT) in filial rat’s brian and learning and memory capacity after the mother-rat is exposed to nonylphenol. Methods:At the first day of the pregnancy,the rats were divided into four groups,which were orally administered with NP at doses of 0,50,100 and 200 mg/kg,respectively,on gestational days 9～15. The offspring rats’s Brain tissues of each groups were dissected for AchE and ChAT activity assay and cognitive function was tested by Morris water maze. Result:Morris water maze test results showed the escape latency was longer in the groups of NP 200 mg/kg than in control group(P

Objective:Toinvestigate the expression of RHAMMgene and TPX2 gene in esophageal squamous cell carcinoma(ESCC)and their relationships with clinicopathological factors.Methods:The expression of RHAMM gene and TPX2 gene were detected by reverse transcriptase polymerase chain reaction(RT-PCR)in ESCC tissues,para-cancer tissues,and matched esophageal normal mucosa tissues of 40 patients.Results:The positive expressions of RHAMM mRNA in ESCC tissues(65.0%)were significantly higher than those in para-cancer tissues(37.5%)and esophageal normal mucosa tissues(22.5%).Significant relationship was observed between positive expression of RHAMM mRNA and lymphnode metastasis(P