Objective To discuss the expression and significance of eotaxin in the nasal secretions of the patients with nasal pol-yps .Methods The nasal secretion samples were collected from 40 patients including 15 cases of nasal polyps ,15 cases of chronic si-nusitis and 10 cases of nasal septum deviation .The enzyme-linked immunosorbent assay(ELISA) was adopted to detect the concen-tration of eotaxin .Results The average concentration of eotaxin was (468 .82 ± 440 .64)pg/mL in nasal polyps ,(443 .85 ± 334 .68) pg/mL in chronic sinusitis and (149 .23 ± 49 .01)pg/mL in nasal septum deviation .The eotaxin concentrations in the nasal polyps group and the chronic sinusitis group were higher than those in the nasal septum deviation group ,the difference was statistically significant(P<0 .05) .Conclusion The eotaxin concentration in the nasal secretions of the patients with nasal polyps is significantly increaseed ,which might be concluded that eotaxin may play an important role in the occurrence and development process of nasal polyps .

Objective: To study the chemical constituents of the fruiting bodies of Ganoderma daiqingshanense. Methods: The constituents were separated by Silica gel and Sephadex LH-20 column chromatography, their structures were elucidated by spectral data analyses, and the acetylcholinesterase inhibitory activity was detected. Results: Twelve compounds were isolated from the fruiting bodies of G. daiqingshanense and identified as 3β,21β-serratenediol-3-acetate (1), 3β,21α-serratenediol-3-acetate (2), 3-O-acetyltohogenol (3), 20 (29)-lupen-3β-ol (4), lucialdehyde A (5), ganoderic acid Y (6), ergosta-7,22E-diene-3-one (7), ergosta-4,6,8 (14),22-tetraene-3-one (8), ergosta-7,22E-diene-3β-ol (9), 5α,8α-epidioxyergosta-6,22E-diene-3β-ol (10), ankylosaurus acid (11), and euphorbia factor L3 (12). Compounds 5, 11, and 12 showed moderate activities against acetylcholinesterase with inhibitory rates of 17.70%, 22.89%, and 21.22%, respectively. Conclusion: All the compounds are obtained from G. daiqingshanense for the first time and serratene triterpenes (compounds 1-3) are found from family Ganodermataceae for the first time. Compounds 5, 11, and 12 have certain inhibitory activities on acetylcholinesterase.

Tsutsugamushi disease is an acute infectious rickettsial disease caused by the intracellular parasite Orientia tsutsugamushi. Due to its variety of clinical signs, this disease is often misdiagnosed. This article examines a total of 4 patients who visited our clinics with fever and sore throat. 3 of them had body temperature of 39.5 Celsius degrees when admitted. The characteristic black eschar occurred on 4 of them. Lymphadenopathy occurred on 2 of them. Cough occurred on 1 of them. Lab tests showed that 3 of them had Leukocytosis, 1 of them had increased bronchovascular markings, and 3 of them had Weil-Felix test positive. After admission, all patients, who were confirmed of diagnosis of tsutsugamushi disease instead of tonsillitis, received the comprehensive treatment and cured afterwards.
Diagnostic Errors ; Humans ; Orientia tsutsugamushi ; Pharyngitis ; etiology ; Scrub Typhus ; complications ; diagnosis ; Tonsillitis ; diagnosis

The advantages of intense pulsed light therapy in the treatment of Meibomian gland dysfunction include non-invasive, painless and good results, which has been greatly developed in the ophthalmology field.This article reviews the current situation, mechanism of action, operating procedures, treatment outcomes, safety, and other aspects of intense pulsed light therapy in the treatment of Meibomian gland dysfunction.

Objective:To investigate the effects of different shapes of implant on stress distribution in implant-bone interface and to select the most appropriate shape for orthodontic anchorage. Method:3-dimesional finite element analysis method was used to analyze the stress and strain in implant-bone interface of knife-edged threaded, square threaded and smooth type implants.Results: The first,second and third main stress (MPa) of knife-edged threaded implant were 6.67, 1.47 and 0.52 respectively with 7.72 MPa of Von Mises stress;those of square threaded 13.00,2.51,0.57 and 11.8;smooth type 10.50,2.50,0.67 and 12.60,respectively. The variables of alveolar bone at the cervix of knife-edged threaded,square threaded and smooth type implants were (0.11×10-3), （0.13×10-3） and （0.94×10-4) mm respectively. Conclusion: The stress in knife-edged threaded implant-bone interface and alveolar bone deformation at the cervix of the implants is minimal,therefore the implants are more suitable for orthodontic anchorage.

Objective:To establish a 3-dimensional finite element model for implant in molar deprived region of mandible. And to lay basis for precise analysis for the biomechanic characteristics of implant anchorage system. Methods:The cross section outline drawn from the molar deprived region of mandible was input into a computer, and ANSYS 5.5 (Swanson Analysis Systems, Inc. Houston, USA) finite element analysis software was used to perform the finite element modeling of the mandible.Results:The cross section outline of the mandible,imitated by a spline curve was smooth and lifelike. This cross section outline was extruded into a three dimensional model. The three dimensional models of the implant and mandible could be smartly meshed to obtain the finite element model of mechanics. Conclusion: An effective 3-dimensional finite element biomechanical analysis model for implant as orthodontic anchorage was established.

Objective To observe the effect of low molecular weight heparin(LMWH) in treatment of diabetic foot.Methods Fifty-four patients were divided into test group and control group randomly.Both two groups were given routine therapy including mediating blood glucose with Insulin,anti-infection and changing dressings,while the test group were givon LMWH 5000IU once datly every 12 hours for 15 days besides the routine treatment.Then the endothelin(ET),thromboxaneB2(TXB2),hemorheology,ankle-brachial index(ABI),ulcer healing,fibrinogen(FIB),prothrombin time(PT) and avtivated parital thromboplastin time(APTT) were observed.Results Compared to that of before treatment,there are ET,TXB2,hemorheology and better ulcer heals after treatment,The improvement in test group patients was superior to that of control group(P0.05) after treatment in two groups.No hemorrhage and other complications occurred.Conclusion LMWH is effective and safe for treatment of diabetic foot.

Objective In recent years , SIT has gradually become the main way for the treatment of allergic rhinitis .To con-trast the clinical efficacy of specific immune therapy for one year and two years of allergic rhinitis and discuss the appropriate mainte -nance treatment time of subcutaneous immunotherapy with Dermatophagoides pteronyssinus . Methods Ninety-eight patients with al-lergic rhinitis to Dermatophagoides pteronyssinus were allocated to receive either treatment for one year (A group, n=46) or treatment for two years(B group, n=52).Nasal symptoms and medication scores of two groups were assessed to evaluate the clinical efficacy af -ter treatment respectively , and evaluate the quality of life of patients . Results There was no statistical significance in nasal symptom and medication scores between the two groups after one year treatment (7.00 ±1.08 vs 6.63 ±0.79, 1.50 ±0.51 vs 0.41 ±0.42, P>0.05).The quality of life in patients with decreased , but lack of statistical significance (345.00 ±31.89 vs 344.42 ±32.26, P>0.05).It presented statistical significance in nasal symptom and medication scores between the two groups after two years treatment (6.20 ±0.78 vs 4.29 ±0.64, 0.53 ±0.43 vs 0.21 ±0.34, P<0.05).The quality of life between patients also presented statistical significance (P<0.05). Conclusion Compared with A group, B group can significantly alleviate the symptoms of allergic rhinitis , so we think the optimal maintenance treatment time of specific immunotherapy for allergic rhinitis should be at least 2 years.

Objective To investigate the relationship between cognitive function and emotional status in functional constipation patients.Methods Thirty-five functional constipation patients (the functional constipation group) and 24 healthy controls (the HCs) were enrolled in an event-related potential (ERP),behavior and electroeneephalogram study while performing an oddball auditory task.Response time,accuracy,latency and P300 amplitude were compared between the two groups.The Hamilton depression rating scale (HAMD-17),Hamilton anxiety scale (HAMA),symptom check list-90 (SCL-90) and Eysenck personality questionnaire (EPQ) were administered prior to the oddball task.Results The average HAMD-17,HAM A and SCL-90 (the somatization,obsessive-compulsive disorder,depression,anxiety and psychosis dimensions) scores of the functional constipation group differed significantly from those of the HCs.The intro-extraversion and neurosis dimensions of the EPQ were also significantly different.There was no significant difference in response time or latency between the two groups.The ERP results showed that the P300 amplitudes at the F3 and F7 sites were significantly different between the functional constipation group and the HCs.But there was no significant difference in P300 latencies at F3 or F7 between the two groups.Conclusions The findings suggest that patients with functional constipation are more susceptible to depression and anxiety,as well as somatization,obsessive-compulsive tendencies and other neurotic personality characteristics.Patients may employ psychological defense mechanisms to avoid the depression and anxiety.The ERP results imply there may be the implicit cognitive dysfunction with emotion in patients with functional constipation.

This study was to investigate the diagnosis value of simplified uredynsmic test in stress urinary incontinence. Fifty patients with stress test-confirmed urine incontinence underwent simplified urodynamic test before routine urodynamic test. Detrusor instability, max bladder volume, average flow rate, and residual urine of simple urodynamic test were compared. Simplified urodynamic test showed a sensitivity of 87%, specificity of 9/12, positive predictive value of 92%, and negative predictive value of 9/14. There was no significant difference in max bladder volume, average flow rate, and residual urine between the two tests. Simplified urodynamic test might be a reliable method for diagnosis of stress urinary incontinence, and could be used for detrnsor instability screening.