Objective:To analyze the factors which affect mandibular third molar angulation changes during treatment of adult orthodontic patients.Methods:80 post-treatment adult patients including 154 mandibular third molars(M3) were selected.The gender,age,clinical classification and treatment methods of the patients were recorded.The pretreatment and post-treatment panoramic radiographs were analyzed.The angulation and the eruption space of mandibular M3 were measured.The root development stages of the mandibular M3 before treatment were evaluated.The factors affecting mandiular M3 angulation changes were analysed by covariance analysis.Results:The results of multi-factors analysis illustrated that the sagittal skeletal classifications,the root development stages of the pre-treatment mandibular M3,the pre-treatment mandibular M3 angulations,the width/space ratios before and after treatment affected the mandibular M3 angulation changes during the orthodontic treatment.Mandibular M3 showed more improvement in angulation in groups of Class I sagittal skeletal classification,the root development stages of the pre-treatment mandibular M3 where the root was fully formed but the foramen apices wasn't closed or the stages where the root less 1/3 was formed,the pre-treatment mandibular M3 angulations 60?,and the more M3 space before and after treatment,the more improvement in M3 angulation.Conclusion:In adult orthodontic patients,the mandibular M3 angulation changes during the treatment can be influenced by many factors,but orthodontic treatment is not the direct factor.

0.05).But there were significant differences in the change in mandibular M3 space among three groups(P

Hereditary hearing impairment is caused by genetic defects and is a common clinical disease. Since the lack of efficient treatment method, genetic counseling is more important in this field. It provides information about inherited disorders and focuses on assessment and interpretation of the risk for occurrence of genetic conditions in the family. Presented in this paper are classification of hereditary hearing impairment and methods to perform probability analysis using features of pathogenic genes and information of pedigree.

MicroRNAs (miRNAs) are small non-coding RNAs which are essential for posttranscriptional gene regulation and have important roles in physiology and pathology. The researches on function of miRNA will be a focus in the future. Several animal models have been built by transgenic technology, making important contributions to our understanding of gene function at the whole scale. Recently, the number of transgenic animal models for microRNAs and construction strategies have been increasing and diversifying. Some roles of miRNA in tumor and cardiovascular disease have been revealed by transgenic animals. Transgenic animals are becoming a kind of powerful tool in microRNA researches.

Objective To establish a method for determination of matrine in Fuji Lotion. Methods An Inertsil NH2 column (250 mm?4.6 mm, 5 ?m) was used with acetonitrile-ethanol absolute-3% phosphoric acid (83∶8.5∶8.5) as mobile phase, the flow rate was 1.0 mL/min, and the UV detection wavelength was set at 220 nm. Results The calibration curve of matrine was linear in range of 0.039～1.560 ?g, r=0.999 7. The average recovery was 97.8% with RSD of 1.1% (n=6). Conclusion The method is simple, quick and accurate. It can be used for the quality control of Fuji Lotion.

Osteoarthritis (OA) is a bone and joint disease caused by multiple factors, which seriously threatens human health. It is mainly manifested as joint pain and dysfunction. In severe cases, it can cause deformity. The mechanism of OA is not very clear, and there is a lack of effective therapeutic drugs; the exploration of etiology, pathogenesis and preventive measures of OA has always been an important research direction in this field. Studies have found that the transforming growth factor-β (TGF-β)/Smad signaling pathway plays a key role in the occurrence and development of OA. This article reviews the research progress of TGF-β/Smad signaling pathway in OA in recent years at home and abroad.

OBJECTIVEThis study aims to compare the treatment outcomes in patients with maxillary dentoalveolar protrusion by applying different anchorage methods via three-dimensional model measurement.

METHODSA total of 46 patients with maxillary dentoalveolar protrusion treated with bilateral maxillary first premolar extractions and high anchorage were selected. The subjects were randomly divided into three groups according to the type of anchorage applied, which included implant, extraoral, and Nance arch anchorages. The maxillary dental models were made before treatment and after space closure of maxilla. The movements of the maxillary central incisors and first molars were measured via a three-dimensional model measurement, and the amounts of movement were compared among the three groups.

RESULTSThe sagittal lingual movements of the maxillary central incisors were (-6.661 ± 1.328), (-5.939 ± 1.806), and (-5.788 ± 2.009) mm for the implant, extraoral, and Nance arch anchorage groups, respectively, with no significant difference among the three groups (P = 0.121). The corresponding vertical movements of the maxillary central incisors were (0.129 ± 1.815) mm intrusion, and (-2.162 ± 2.026), (-2.623 ± 1.776) mm extrusion. Significant difference was found between the implant anchorage group and the other groups (P < 0.05). The corresponding sagittal mesial movements of the maxillary first molars were (0.608 ± 1.045), (1.445 ± 1.462), and (1.503 ± 0.945) mm. The corresponding vertical movements of the maxillary first molars were (0.720 ± 0.805) mm intrusion, (0.076 ± 0.986) mm intrusion, and (-0.072 ± 0.690) mm extrusion. Significant difference was found between the implant anchorage group and the other two groups (P < 0.05). In the transverse direction, the first molars all moved lingually with no significant difference among the three groups (P > 0.05).

CONCLUSIONImplant anchorage may be superior in the vertical control of the maxillary incisors and in the sagittal, as well as in the vertical control of the maxillary molars, compared with the traditional anchorages during the treatment of patients with maxillary dentoalveolar protrusion.

Objective To investigate the clinical value of mitral valve quantitative(MVQ)soft ware,select the significant parameters in diagnosing mitral valve prolapse and analysis the mechanism of mitral valve regurgitation by MVQ in clinical.Methods Live three dimensional transesophageal echocardiography was performed on thirty-one patients,in which 13 patients with mitral valve prolapse,another 18 patients with suspected intracardiac thrombosis without mitral valve regurgitation regarded as control group.The images were stored and processed with MVQ soft ware off line.Eighteen parameters of mitral valve structure were measured in mitral valve 3D mode.Results Comparing with the control group,the parameters of mitral valve annulus of mitral valve prolapse were larger significantly(P＜0.05).Seven parameters of mitral valve leaflets,θant,θpost,θNPA,Htent,Vtent,L2DALPm,θAv-Mv,had no significant difference between tWO groups(P＞0.05).L3Dant,L3Dpost,Hprol,Vprol,A3Dpost,A3Dant of mitral valve prolapse were larger than those of control group(P＜0.05).Conclusions MVQ can measure the parameters of mitral valve stereo structure quantitatively,result in more detailed diagnosis of mitral valve disease by echocardiography,provide more important information to surgeons,and help them to formulate detailed and complete operation scheme.

OBJECTIVE:To investigate the characteristics and regularity of ADR induced by Iobitridol injection,and to provide reference for clinical drug use.METHODS:In retrospective study,the information of 72 patients suffering from ADR induced by Iobitridol injection were collected from our hospital during Jul.2015 to Jul.2016,and then statistical analysis was conducted in respects of age,gender,primary disease,organs/system involved in ADR,clinical manifestations,relationship evaluation and degree,occurrence time,outcomes,etc.RESULTS:Among 72 cases of ADR,the number of female was about twice of that in male.The age mainly distributed in the range of 50 to 80 years old (80.56％).ADR mainly occurred in skin and its appendants (30.57％),followed by systemic reactions (22.93％) and circulatory system (21.66％).ADR occurred within 20 min after medication (38.89％).58.33％ of ADR patients were cured,and 41.67％ were recovered.CONCLUSIONS:During the application of Io bitridol injection,a detailed understanding should be obtained about the patient's condition,medical history and the results of the examinations.Medical staff should inform the patient of the possible allergic symptoms,and do a good emergency preparation.