OBJECTIVE To explore the occurring characteristic and curing measures of hospital infection for inpatients with cardiovascular disease.METHODS The data of hospital infection for inpatients with cardiovascular disease from Jan to Dec,2004 were analyzed retrospectively.RESULTS The total incidence of hospital infection was 3.38% for inpatients with cardiovascular disease.The infection located as follows: 157 patients were in lower respiratory tract(48.2%);66 patients in upper respiratory tract(20.2%);40 patients in urinary tract(12.3%);33 patients in gastrointestinal tract(10.1%);and 18 patients were in cutis tissue ((5.5%).) CONCLUSIONS Pneumonia is one of the inducing factors to heart failure for patients with cardiovascular disease.Applying antibiotics reasonably,aseptic operation and treating the primary affection could decrease the incidence of hospital infection.

Objective:To analyse the biological function of anti-IL-6Rβ(gp130) monoclonal antibody and its regulatory effect on IL-6 signaling.Methods:Biological characteristics of anti-IL-6Rβ(gp130) mAb were assessed by Western blot analysis, capture ELISA and peptide ELISA .The phosphorylation of STAT 3 was tested by Western blot analysis in IL-6-stimulated U266/RA-FLS/RA-PBMC with or without anti-IL-6Rβ(gp130) mAb treatment.Results:3 strains of mouse anti-human gp130 mAb were with high affini-ty and different binding epitopes , the kaff of 10A1 was 2.62E-10.In U266, RA-PBMC and RA-SFMC, IL-6 signaling highly activated STAT3 which could be inhibited by anti-gp130 mAb.Conclusion: Anti-IL-6Rβ( gp130 ) mAb might have different binding epitopes and could affect IL-6 stimulated phosphorylation of STAT3, which provides a preliminary experiment for analyse the correlation of IL-6 signaling and RA .