Introduction: A number of risk factors predispose an individual to hepatic drug Thus, there is need to develop a effective hepatoprotective formulation which could reduces of such liver complications caused due to hepatotoxic agents etc. The present work was focused on the investigation of hepatoprotective activity of various herbal formulations “Adapton 6” containing aqueous as well as hepatoprotective crude drugs. The herbal drug ingredients of Astragalus membranaceae (Астрагала перепончатого), Rhaponticum cartamoides (левзеи), Rheum palmatum L (ревеня), Rosa cinnamomea (плоды шиповника), Crataegus sanguine Pall (боярышника) and Hippophae rhamnoides L (облепихи) Purpose: The present study aims to examine the effects of Hepatoprotective activity of multicomponent herbal drug “Adapton 6”Materials and Methods: The hepatoprotective effect was studied further in rats, using carbon tetrachloride (CC!4)-induced hepatotoxicity as in vivo model. The Hepatoprotective activity of “Adapton 6” were evaluated and compared statistically after inducing hepatotoxicity in rats by intraperitonally administration of carbon tetrachloride (CCL4) with olive oil 50% as a diluent in 3 times 1 day. The liver damage was confirmed by estimation of elevated levels of cytoplasmic enzymes Serum Glutamate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), Alkaline Phosphatase (ALP), serum bilirubin and malondialdehyde (MDA), hydroperoxides, glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT).Result: On intraperiteonally administration of CCl4 in dose of 100 mg/kg produced acute hepatic damage in positive control (carbon tetrachloride treated) when compared with normal control. In treats groups, formulations “Adapton 6” were administered simultaneously with CCl4. Estimated levels of enzymes SGOT, SGPT, SALP and bilirubin in test groups were compared with levels of enzymes in normal, control groups. These show hepatoprotection effect but other due to antioxidant effects like exist of malondi-aldehide and catalase (CAT) activities.Conclusion: On conclusion, the prepared multicomponent herbal drug “Adapton 6” has demonstrated a very good hepatoprotection against the CCl 4 induced liver damage.

dicamentous therapy of liver disease there was a necessity to investigate herbal medicine possibility in traditional medicine. In Mongolian traditional medicine more than hundred prescriptions based on animal, mineral raw materials and more than 210 species of plants in various combinations used for liver remedy. But among them the greatest interest has caused us a plant named Chiazospermum erectum L., from the family of Hipecoaceae. In traditional medicine this plant is applied at liver infectious diseases as febrifugal, soothing, at some oncological diseases, diseases of a teeth, and mucous a pharynx. Aim of study was investigation of hepatoprotective effect of Chiazospermum erectum L. (dry extract) on experimental D-galactosamine hepatitis. Methods: Dry extract of Chiazospermum erectum L. was investigated on the experimental D-galactosamine hepatitis. It is well known D-galactosamine caused hepatitis demonstrated very similar pathogenesis and simptoms with viral hepatitis, especially with B-viral infection (Bluger A.F, Maiore A.Ya 1978). The experimental hepatitis was developed in Vistar bred laboratory rats (n=75) by intraperitoneal introduction of D galactosaminein a dose of 0.4 g/kg of animal weight. To animals of the first experimental group, since the beginning of experiment was intragastrically administered extract of Chiazospermum erectum L. in the form of water solution in a dose 25 mg/100gr of animal weights once per day within 14 days. To animals of other experimental group was administered a water solution of comparing (standard) preparation – Cholosasum into volume of 1.0 ml/100 g. In control group under the similar scheme introduced the distilled water in equivalent volume. The interval between administering of D galactosamine, standard preparation and distilled water was 5-6 hours. Results: The hepatoprotective activity of the dry extract of Chiazospermum erectum L. studied on ferment activity ALT, AST in experimental D-galactosamine hepatitis. The AST and ALT levels in the animals of experimental group was 20% and 46% lower than in indices of control group, and the levels of cholesterol, -lipoprotein and bilirubin were 18%, 12% and 14% lower, respectively. Chiazospermum erectum L. demonstrated a hepatoprotective activity on D-galactosamine hepatitis same with a standard remedy – Cholosasum. Conclusion: ThedryextractfromtheaerialpartofChiazospermum erectum L. during intragastric administering to laboratory animals with D- galactosamine liver damage reducing cytolytic syndromes and choleostasis, promoting the accelerated normalization of its functional condition. Chiazospermum erectum L. demonstrated a hepatoprotective activity on D-galactosamine hepatitis same with a standard remedy – Cholosasum. The received results demonstrated a further possibility of the studying of this plant for preventive maintenance and treatments of viral hepatitis and its complication