1.Initiating or switching to insulin degludec/insulin aspart in adults with type 2 diabetes in the Philippines
Nemencio Nicodemus Jr. ; Nerissa Ang-Golangco ; Grace Aquitania ; Gregory Joseph Ryan Ardeñ ; a ; Oliver Allan Dampil ; Richard Elwyn Fernando ; Nicole-therese Flor ; Sjoberg Kho ; Bien Matawaran ; Roberto Mirasol ; Araceli Panelo ; Francis Pasaporte ; Mercerose Puno-Rocamora ; Ahsan Shoeb ; Marsha Tolentino
Journal of the ASEAN Federation of Endocrine Societies 2024;39(2):61-69
OBJECTIVES
Blood glucose levels of the majority of Filipino patients with type 2 diabetes (T2D) remain uncontrolled. Insulin degludec/insulin aspart (IDegAsp) is a fixed‑ratio coformulation of the long‑acting basal insulin degludec and the rapid acting prandial insulin aspart. The realworld ARISE (A Ryzodeg® Initiation and Switch Effectiveness) study investigated clinical outcomes across six countries in people with T2D who initiated IDegAsp. This publication presents the clinical outcomes of the Filipino cohort from a subgroup analysis of the ARISE study.
METHODOLOGYThis 26-week, openlabel, noninterventional study examined outcomes in adults with T2D initiating or switching to IDegAsp (N=185) from other antidiabetic treatments per local clinical guidance.
RESULTSCompared with the baseline, there was a significant improvement in glycated hemoglobin at the end of the study (EOS) (estimated difference [ED] −1.4 [95% confidence interval −1.7, −1.1]; P < 0.0001). Fasting plasma glucose (ED −46.1 mg/dL [−58.2, −34.0]; P < 0.0001) and body weight (ED −1.0 kg [−2.0, −0.1]; P = 0.028) were significantly reduced at EOS compared with baseline. IDegAsp was associated with a decrease in the incidence of selfreported healthcare resource utilization. Adverse events were reported in eight (4.3%) participants.
CONCLUSIONInitiating or switching to IDegAsp was associated with improved glycemic control, lower body weight, and lower HRU for people with T2D in the Philippines. No new, unexpected AEs were reported.
Human ; Insulin Aspart ; Insulin Degludec ; Diabetes Mellitus, Type 2
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