OBJECTIVE:To evaluate the clinical efficacy of combination of low molecule heparin calcium with Asipilin for early acute cerebral infarction.METHODS:A total of 320 patients with early acute cerebral infarction were randomly assigned to low molecule heparin calcium group,aspirin group,combination treatment group(low molecule heparin calcium group plus aspirin)or control group.The clinical efficacy in 4 groups was evaluated respectively.RESULTS:The nerve function showed a better recovery in all the treatment groups than in control group.As compared with low molecule heparin calcium group or aspirin group,the combination treatment group showed a significantly improved nerve function and higher clinical efficacy.There were significant differences in total effective rate among groups after treatment for different time(P0.05).CONCLUSION:The combination of low molecule heparin calcium with Asipilin for early acute cerebral infarction is safe and more effective than low molecule heparin calcium and Asipilin used alone.