Intestinal trefoil factor(ITF)is a low molecular weight polypeptide expressed in intestine. ITF is also found in the brain,respiratory,eyes and so on.To study recombinant ITF will have an important impact for the treatment of gastrointestinal disease, respiratory tract disease, eyes disease and so on.

With the development of perinatal medicine,the survival rate of preterm infants has risen these years,and the incidence of bronchopulmonary dysplasia (BPD) has also increased as a result.BPD is a chronic lung disease which is caused by multiple factors,It has complicated etiology and pathogenesis,high mortality early after birth,and high incidence of later adverse outcomes in respiratory and nervous systems,which seriously affect the survival rate and quality of life in preterm infants.This article will summarize the current situation in prevention and treatment of BPD.

Sepsis is one of the most important causes of death in critically ill children.The leading cause of sepsis is bacterial infection.The early diagnosis of bacterial infection allows initiation of appropriate antimicrobial therapy that strongly correlates with positive outcomes.At present,the methods of detection and identification of bacteria in our country are still at the level of blood culture and biochemistry,and they have the weakness of time-consuming process and lower positive rate.Therefore,it is very important to establish a rapid and sensitive diagnostic method for early diagnosis of bacterial infection.In recent years,with the rapid development of molecular detection technology,some new molecular biological technologies can not only improve the detection accuracy and sensitivity,but also reduce the detection hours and expand the detection pathogen spectrum.Nowadays,they have been applied to bacteria classification and identification.There are two kinds of molecular biological technology that are applied at present.One is based on nucleic acid detective technology,such as nucleic acid amplification,DNA sequencing,gene chips,etc.The other is based on proteome technologies,such as biological mass spectrometry.In this paper,the application of recent molecular biological techniques in the rapid detection of bacteria is reviewed.

As the increasing of digital imagilag modalities,a close-at-hand challenge to deal with is the storage and transmission requirement of enormous data of medical images.Compression is one of the indispensable techniques to solve this problem.A comprehensive review and discussions are made in this paper over the medial image compression techniques applied in medical image domain,including the latest achievements in this field.Different compression algorithm including ROI-based coding,lossless compression,DWT,neural net are introduced and some quality evaluation methods are introduced.Foreground of the field is given from our point of view.

BACKGROUND:Discogenic pain is a major cause of chronic low back pain,and its inflammation mechanism that is participated by many cytokines is well known by more and more people. However,what is the role of these cytokines in the occurrence and development of pain and how we use them to control pain are still not consistent. OBJECTIVE:To completely learn about the pathogenesis of intervertebral disk herniation,the relative cytokines in the occurrence and development of pain and the advances in the treatment of chronic pain with cytokines. RETRIEVE STRATEGY:A computer-based online search of CNKD was undertaken to identify the relevant articles dated from January 1994 to June 2007 with the Chinese of "cytokine,pain". And totally 153 articles were collected. Meanwhile,PubMed database was searched for English articles published from January 2002 to June 2007 with the keywords of "gene,chronic pain" and 36 were collected. The articles that involved the basic and clinical researches closely related with cytokine were selected. Repetitive articles were excluded. After the trail,6 Chinese and 24 English articles were involved. LITERATURE EVALUATION:Of the 30 articles,10 were focused on the basic research and animal experiment,and 20 were about clinical research. There were 7 of RCT,1 of EBM review,10 of summary analysis,2 of case report,and 10 of experience exchange. DATA SYNTHESIS:The mechanisms of discogenic pain include inflammation and immune ones besides mechanical pressure. Inflammation mechanism of discogenic pain is well known by more and more people,in which many cytokines such as substance P,phospholipase A2,tumor necrosis factor,interleukin,growth factor and NO participate. Meanwhile,the role of immunities should not be ignored. Some researchers have used some cytokines(interleukin 1 receptor antagonist,vascular endothelial growth factor,etc) in clinic to treat pains and got good effect. CONCLUSION:The mechanism of pain and various effects of pain-killer are based on gene. Cytokines play important roles in the occurrence,development and treatment of discogenic pain.

OBJECTIVE:To investigate the efficacies and safety of paclitaxel (PTX) versus Taxotere (TXT) and fluorouracil (5-FU) versus cisplatin (DDP) (PCF vs.DCF regimens) in the treatment of advanced gastric cancer (AGC).METHODS:60 cases of AGC were divided into two groups according to different regimens.The patients in group PCF (n=30) received 35～50 mg?m-2 PTX via ivgtt for 3 hours on the 1st,8th,15th day.The patients in group DCF (n=30) received 35 mg?m-2 TXT via ivgtt for 1 hour,on the 1 st,8th,15th day.Both groups were given 750 mg?m-2 5-FU with continuous infusion administration from the 1st to 5th day and 20 mg?m-2 DDP via ivgtt for 2 hours from the 1st to 5th day with treatment course of 28 d.Recent efficacy and safety were evaluated after two cycle of treatment and long-term efficacy were followed up continuously.RESULTS:Overall response rate (ORR) was 50.0% for group PCF and 46.6% for group DCF.Disease control rate (DCR) was 66.6% in group PCF and 63.3% in group DCF.The median survival time (MST) was 10.4 months in group PCF and 9.6 months in group DCF.One-year survival rates were 35.7% for group PCF and 34.4% for group DCF.There was no statistically significance in recent and long-term efficacy between two groups.Grade Ⅲ/Ⅳ toxicities represented as bone marrow depression,nausea,vomiting and alopecia in two groups.Grade Ⅳ neutropenia and the overall incidence of anemia,DCF was significantly higher than the PCF group.CONCLUSION:PCF and DCF regimens have similar response in the treatment of advanced gastric cancer.Drug toxicity of two regimes are different while both of them are tolerable well.

Platelet glycoprotein ⅡbⅢa receptor antagonists is a class of novel antiplatelet agents. This article explores the application and prospect of platelet glycoprotein ⅡbⅢa receptor antagonists in ischemic stroke from the aspects of its combination with thrombolytic agents, the application of carotid artery angioplasty and stenting (CAS), and be used alone.

This article pointed out that the Suiqisuode theory was the basic pathogenesis of viral myocarditis by analysing that theory.

Objective To observe the therapeutic effects of comprehensive rehabilitation treatment in patients with chronic renal failure (CRF). Methods Fifty patients with CRF were randomly and equally divided into a rehabilitation group and a control group. Those in the rehabilitation group were intervened with comprehensive rehabilitation protocol including regular counseling, health education and adequate aerobic exercise in addition to routine medications, while those in the control group with the routine medications only. The therapeutic effects were evaluated by means of Symptom Check List- 90(SCL- 90) and the questionnaire about quality of life (QOL) for patients with CRF, as well as such biochemical parameters as SCr, BUN, Ccr, DBP and SBP before and after treatment. Results Compared with those in the control group, the physiological capability and other relevant parameters of QOL in the rehabilitation group were significantly improved after one year of comprehensive rehabilitation, while SBP and DBP significantly decreased. There was no statistically significant changes of the concentrations of Scr, Bun, and Ccr. Conclusion Comprehensive rehabilitation intervention is superior to routine drug therapy in terms of improving the physiological capability, decreasing the BP and improving the QOL of the CRF patients.

Objective To investigate the influence of WeChat on compliance of chronic obstructive drsease(COPD)patients after discharge.Methods Eighty COPD patients were divided into observation group and control group in equal number.The former received health education by WeChat, while the control group regular revisits.The two groups were compared in terms of the compliance in mediation and dieting as well as readmission.Result The rate of compliance in mediation and dieting in the observation group was significantly higher than that in the control and the rate of readmission significantly lower than that in the control group(P<0.05). Conclusion Health education by way of WeChat for COPD patients can enhance their compliance in medication and consolidate the curative effect.