The study was carried out on 100 healthy rats, weight of 12020g which were divided into 10 groups. Raw materials: BB103 pure powder and mefloquine. Results: In rats received BB103 with doses of 50 mg/kg and mefloquine 50 mg/kg in 5 days, there were no significant changes on process of conditioned reflex, speed of reflex establishment was stable, response time and extinguishing time of reflex were similar to those of the control group (p>0.05). In rats received BB103 with doses of 100 mg/kg and mefloquine 100 mg/kg in 5 days, there were significant changes on speed of reflex establishment and response time (p<0.01-0.05). There were differences on speed of reflex establishment, speed of stable reflex in rats received BB103 and mefloquine (p<0.01-0.05)
Artemisinins ; Rats ; Animal Experimentation

A assessment of influences of pentaflouropropyloxydihydroartemisinin (BB.103) and mefloquine on functions of the nervous system of rats. The results showed that: BB.103 with doses 50mg/kg x 5 days (1 and 2 times), and mefloquine doses 50mg/kg x 5 days were found not to influence conditional reflex of rats. The changes of speed of establishment of reflex, speed of establishment of stable reflex, time of consolidation of reflex were found to be unstatically significant as compared to the control. BB.103 with doses 100mg/kg x 5 days (1 and 2 times), and mefloquine doses 100mg/kg x 5 days was found to influence the time of establishment of conditional reflex of rats. The changes were statically significant compared with control group
Mefloquine ; Nervous System ; Rats ; drugs ; animals ; Artemisinins

Preclinical trial of effects of pentafluoropropyloxydihydroartemisinin (BB203) and mefloquine on nervous functions was carried out in white mice. BB103 with doses of 50mg/kg x 5 days didn’t affect to conditional reflex of searching for food in mice, but BB103 with doses of 100mg/kg x 5 days did. Use mefloquine with doses of 50mg/kg x 5 days and 100mg/kg x 5 days that had significantly increased the speed of establishment of reflex, speed of establishment of stable reflex, number of times with consolidation to extinguish the reflex
Nervous System ; Pharmaceutical Preparations ; Mice ; drugs ; artemisinins

Investigating the influence of trifluoromethylhydroartemisinin (BB.101) on chromosome mutations of mice. Mices were divided into 4 batches (B1, B2, B3 were dosed with BB.101 50mg/kg/day x 5 days, once, twice and thrice, respectively; each treatment course was repeated with 7 days intervals. B4 (control) were tested with arabic gum emulsion 1%). The results showed that: BB.101 were found not to increase frequency of confused chromosome in bone marrow cells of mices. Cells with confused structures and trouble clusters as crushed and smudged chromosomes were not found. BB.101 with the same dose was found not to increase frequency of confused chromosome in testicle cells of mices
Chromosomes ; Mice ; artemisinins

At the dose of 4 and 8 mg/kg/day for 30 consecutive days, the monkeys appeared to have normal living actions taking meals and drink. Their body weights did not change significantly. At the dose of 4mg/kg/day for 30 consecutive days, changes of SGOT and creatinine indices were not significant but erythrocyte, reticulocyte, leucocyte and SGPT indices changed significantly. These indices became normal 15 days after interruption of the drug administration. At the dose of 8 mg/kg/day for consecutive 30 days, the changes of SGOT index was not significant during the administration. Haemoglobin, erythrocyte, reticulocyte, leucocyte, SGPT and creatinine indices were significantly changed during the 30 days administration. Haemoglobin, erythrocyte, reticulocyte, SGPT and creatinine indices changed significantly but erythrocyte and leucocyte indices became normal 15 days after the drug administration
Toxicity ; animals ; Haplorhini ; Artemisinins

Study affect of artesunate at close of 50mg/kg in day 1 and 25mg.kg per day four days later. The result showed that: Artesunate with that close had no effect to the birth process of P, F1 and F2: concretely: not make disorderly of reproductive; no have born malformation among generation P, F1, F2 mice. Quantity and weight of born mice were normal. Difference between artesunate group and control group was not statistically significant.
Mice ; Reproduction ; Group Processes ; Artemisinins

Artesunat at doses of 50 mg/kg the first day and 25 mg/kg per day for four following days had no effect to the birth progress of P, F1 and F2. Concretely: No coffuse birth: ratio of conjugation, conception, early died feotus and late died feotus among P, F1 and F2 were similar, and were not higher than control group. No innate defects in born mice from P, F1 and F2. Quantity and weight of mice were in normal, and were not different with the control group
Artemisinins ; Pharmaceutical Preparations ; Therapeutics

Trifluoromenthylhydroartemisinin (ART-F) was tested toxicity on the nervous system in mice, rats. The result showed: ART_F with dosed 50mg/kgx5days were not the conditional reflex searching for food and sensation-movement self defense reflex in mice, rats, but with doses 100mg/kgx 5 days had changed
Nervous System ; Animals ; Animal Experimentation ; drugs

The BB 1O1's effects on the reproductive progress of parents (P), the first (Fl) and the second (F2) generations of mice were investigated at the National Institute of Malariology, Parasitology & Entomology (NIMPE) between February and October 2004. The mice were dosed with BB 101 50mg/kg/day for 5 consecutive days. BB 101 was found to cause no effects on birth progress, mating rate, fertilization. Early died fetuses and late died fetuses were similar among P, F1 and F2. The new born mice were found to have no innate defects. Their size and weight were normal.
Reproduction ; Animal Experimentation ; Mice

The BB134's sub-chronic toxicity in rabbits was investigated at NIMPE's laboratory. BB134 was orally administered at the dose of 9mg/kg of body weight per day for 28 consecutive days. The influence of BB134 on rabbit's laboratory indices and cardiovascular system were observed during and after the BB134 administration. The BB134 had not change the normal indices of development as well as the biochemical and some hematological indices of the experimental rabbits. During the study time the rabbits acted and ate normally. The body weight was increased significantly. SGOT, SGPT, bilirubin and creatinine as well as leukocytes, leukocyte formula and hemoglobin had no change. However erythrocytes decreased significantly by day 14. BB134 was also found not to affect significantly on rabbits' cardiovascular system (rabbits' heart rhythms and cardiovascular waves such as P, QP, QRS, T and QT of the control and treated groups were not changed significantly
Malaria ; Animal Experimentation ; Artemisinins