1.Viral load suppression and acquired HIV drug resistance in adults receiving antiretroviral therapy in Viet Nam: results from a nationally representative survey
Vu Quoc Dat ; Bui Duc Duong ; Do Thi Nhan ; Nguyen Huu Hai ; Nguyen Thi Lan Anh ; Huynh Hoang Khanh Thu ; Tran Ton ; Luong Que Anh ; Nguyen Tuan Nghia ; Nguyen Vu Thuong ; Khuu Van Nghia ; Tran Thi Minh Tam ; Tran Phuc Hau ; Nguyen Duy Phuc ; Vu Xuan Thinh ; Nguyen Tran Hien ; Truong Thi Xuan Lien ; Silvia Bertagnolio ; Nguyen Thi Thuy Van ; Masaya Kato
Western Pacific Surveillance and Response 2018;9(3):16-24
Objective:
The purpose of this survey was to estimate the prevalence of viral load (VL) suppression and emergence of HIV drug resistance (HIVDR) among individuals receiving antiretroviral therapy (ART) for 36 months or longer in Viet Nam using a nationally representative sampling method.
Methods:
The survey was conducted between May and August 2014 using a two-stage cluster design. Sixteen ART clinics were selected using probability proportional to proxy size sampling, and patients receiving ART for at least 36 months were consecutively enrolled. Epidemiological information and blood specimens were collected for HIV-1 VL and HIVDR testing; HIVDR was defined by the Stanford University HIVDR algorithm.
Results:
Overall, 365 eligible individuals were recruited with a mean age of 38.2 years; 68.4% were men. The mean time on ART was 75.5 months (95% confidence interval [CI]: 69.0–81.9 months), and 93.7% of the patients were receiving non-nucleoside reverse transcriptase inhibitor-based regimens. Of the 365 individuals, 345 (94.7%, 95% CI: 64.1–99.4%) had VL below 1000 copies/mL and 19 (4.6%, 95% CI: 2.8-–7.5) had HIVDR mutations.
Discussion
Our nationally representative survey found a high level of VL suppression and a low prevalence of HIVDR among individuals who received ART for at least 36 months in Viet Nam. Continued surveillance for HIVDR is important for evaluating and improving HIV programs.
2.The first community outbreak of COVID-19 in Viet Nam: description and lessons learned
Nhu Tran Duong ; Mai Thi Le Quynh ; Tran Nguyen Hien ; Nghia Duy Ngu ; Trong Nguyen Khoa ; Hai Nguyen Tuan ; Anh Tran Tu ; Huy Ngo Tu ; Phuong Vu Hoang Mai ; Duc Dang Anh
Western Pacific Surveillance and Response 2021;12(2):42-50
Objective: At the time of this study, the prevention of novel coronavirus disease 2019 (COVID-19) relied solely on nonpharmaceutical interventions. Implementation of these interventions is not always optimal and, consequently, several cases were imported into non-epidemic areas and led to large community outbreaks. This report describes the characteristics of the first community outbreak of COVID-19 in Viet Nam and the intensive preventive measures taken in response.
Methods: Cases were detected and tested for SARS-CoV-2 by real-time reverse transcriptase polymerase chain reaction. Contact tracing and active surveillance were conducted to identify suspected cases and individuals at risk. Clinical symptoms were recorded using a standardized questionnaire.
Results: In Vinh Phuc province from 20 January to 3 March 2020, there were 11 confirmed cases among 158 suspected cases and 663 contacts. Nine of the confirmed cases (81.8%) had mild symptoms at the time of detection and two (18.2%) were asymptomatic; none required admission to an intensive care unit. Five prevention and control measures were implemented, including quarantining a community of 10 645 individuals for 20 days. The outbreak was successfully contained as of 13 February 2020.
Discussion: In the absence of specific interventions, the intensive use of combined preventive measures can mitigate the spread of COVID-19. The lessons learned may be useful for other communities.