7.Safety of Intravitreal Ciprofloxacin in Phakic Rabbit Eyes Determined with Electroretinography.
Journal of the Korean Ophthalmological Society 1995;36(8):1295-1301
This study was conducted to determine the safe intravitreal dosage of ciprofloxacin. Twenty-four phakic eyes of New Zealand pigmented rabbits were used. Each group(4 eyes) received midvitreal ciprofloxacin of 100, 200, 400, 600, 800 micro gram in 0.1ml BSS Plus, or 0.1ml BSS Plus only as control. We evaluated retinal function by measuring the electroretinograms for a graded series of flash intensities and fitting b-wave amplitudes to the Naka-Rushton equation. At a dose of greater than 600 micro gram, Rmax decreased signifantly and log K increased signifantly. N-value decreased slightly. B-wave amplitude decreased as a toxic response of intravitreal ciprofloxacin in a dose dependent manner, and this response was best detected using lower luminance stimuli. Lower luminance electroretinography revealed a significant decrease in b-wave amplitude in eyes injected with a dose of 400 micro gram or more. We concluded that 200 micro gram will be the safe intravitreal dosage of ciprofloxacin in phakic rabbit eyes.
Ciprofloxacin*
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Electroretinography*
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New Zealand
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Rabbits
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Retinaldehyde
8.Experimental study of survival of arterialized venous flap.
Hyun Soo KIM ; Bom Joon HA ; Joon Young CHOI ; Sang Eun KIM ; Jae Jung KIM ; Weon Jin PARK ; Jae Seung LEE ; Myoung Soo SHIN ; In Chul SONG
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1998;25(6):978-987
To increase the survival area of the venous flap, we studied the arterialized venous flap in a rabbit ear model. The ears of 12 New Zealand white rabbits(n=24) were randomized into three groups, group A receiving arterio-venous anastomosis 14 days before the arterialized venous flap elevation; group B receiving bipedicled flap elevation 14 days before arterialized venous flap elevation; group C receiving no pretreatment before the arterialized venous flap elevation. Tc -pertechnetate scan was performed on all groups immediately after the arterialized venous flap elevation to evaluate the blood flow of the flap. The survival area of the flap was measured 14 days after the arterialized venous flap elevation. Average ratio of survival area was 92% in Group A, 88% in group B, which were comparatively higher than the 12% in group C. The entire flap was visualized in groups A and B on scan images, however, only the proximal area of the anterior and posterior marginal vein was visualized in group C. Flap survival pattern was similar to that of the scan image and the slope of time-activity curve of groups A and B was much steeper than that of group C. High survival rate of group A, which received the arterio-venous anastomosis as a pretreatment, may be due to the decrease of resistance of outflow during the 14 days. Anticipated mechanisms involved are, valve insufficiency due to high pressure arterial inflow, development of vascular collaterals in the flap, and opening of arteriovenous(A-V) shunt. Bipedicled flap elevation as a pretreatment may not effect on valves, however, may impair the sympathetic nerve and cause ischmic stimuli which in turn may develop vascular collaterals and make an opening of the A-V shunt.
Ear
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New Zealand
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Survival Rate
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Veins
9.Sho, the Diagnostic Basis of Kampo Medicine ---Classical Concept vs. New Concept---
Kampo Medicine 2007;58(4):699-704
The practice of Chinese medicine has continued for more than 2,000 years, based on its long record of effectiveness. In this regard, Kampo medicine has also been used successfully for these many years, and it is still equally effective today, reflecting the fact that humans have changed little during that duration. In fact, it is said that humans have not undergone much evolutionary change in the last four million years. In contrast to this, however, are the ongoing changes in our environment and surroundings, which are giving rise to a host of new diseases, including many that are allergy-related.In the Japanese system of Kampo medicine, the pathophysiological diagnosis (Sho) and treatment are decided on the basis of two venerable texts, Shokanron and Kinkiyoryaku. There is, as a matter of fact, a prevailing, and possibly too extreme, opinion among Kampo practitioners that Kampo methods and medications not found in these two manuals are not to be applied. However, it is thought that changes had already been made to these texts in 1065-1066 by Rinoku et al., and possibly also by others earlier during the Song Dynasty (960-1279). Furthermore, two other texts, Ishimpo and Taiheiseikeiho, present many points that differ from those found in Shokanron. Thus, it is highly likely that Sho is also based on other revisions possibly carried out on these texts (originally authored by Cho Chukei) before Rinoku et al., if not on their own revised versions. From this, it must be realized that revision itself is not a bad process, and rather that the changes for which Rinoku et al. were responsible are quite in harmony with the present age.We must not be afraid to break with an old style. From the early days of Kampo medicine, Sho was assessed on the basis of the four available examination methods (visual examination, examination according to hearing and smell, questions and answers, and palpation). The field of medicine has since undergone some remarkable transitions, and its current state is one of tremendous development. As part of these newly acquired abilities, elevated levels of leucocytes and CRP as reflecting the state of the disease, for example, can be incorporated into the assessment of Sho. In this sense, Kampo practitioners should adopt and apply useful methods also originating from Western medicine. As a matter of fact, this is in line with the preface of Shokanron, which states that useful medications and methods should be gathered as broadly as possible ( ?? ).
Medicine, Kampo
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Medicine
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Diagnostic
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Classical
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New
10.Clinical Trial of a New Bed-Sensor Using Pyroelectric Type Infrared Sensor
Hideyuki SHIBUYA ; Sonoko OGIWARA ; Keiko OZAWA ; Mika KAMISHIMA ; Tazuko UEMATU ; Kazuaki INOUE
Journal of the Japanese Association of Rural Medicine 2008;57(4):650-655
To prevent accidental falls in medical facilities, various types of bed-sensors have been produced by the clinical engineering department of our hospital. In this study a newly developed bed-sensor using a pyroelectric type infrared sensor was evaluated. The features of this bed-sensor are that it costs only 4,000 yen and can be installed anywhere on beds. It was found that the pyroelectric type infrared sensor (AMN13112) made by Matsushita Electric Works served our purpose. We test used the new bed-sensor in the for three months in the patient's ward and in the health care facility for the elderly attached to our hospital, as the systems to monitor patients who are attempting to get up, to prevent patients from leaving the bed unattended, and to replace the conventional floor sensor. As a result, it was formed that the new sensor is very usable in these applications and is also excellent in safety. But when the bed-sensor was installed in a wrong position, it was activated as a typicel nurse call system. For practical use, some improvements are necessary in stabilizing detection distance and precise control of sensitivity.
Sensors
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seconds
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Type 1
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New
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Hospitals