Objectives: Aim of this study is to define peripheral analgesic effect of the traditional drug Garid-5 in mice. Methods: Garidi-5 produced in drug manufacture of Traditional Medical Science, Technology and Production Corporation of Mongolia was used for the study. All animals used in this study were taken care of under ethical consideration, with approval from Ethical Committee Corporation and Minister of Health of Mongolia. LD50 of Garidi-5 was determined by Chan Chi’s method. Mice of either sex weighing 20-30 g were fasted overnight and divided into three groups with six animals in each group. One hour after administration of drugs, induction of writhing was done in mice by giving intra peritoneal injection of acetic acid at a dose of 10 ml/kg body weight. The number of writhing responses were counted and recorded for 20 min. Garid-5 was given to mice at doses of 20 mg/kg, 80 mg/kg, and 200 mg/kg. Aspirin (100 mg/kg) was used as a standard drug. Results: The median lethal dose (LD50) of Garid-5 was found to be 2.28 g/kg. Aqueous extract of Gardi-5 reduced pain from 40.4 % to 47.9% in mice administered acetic acid compare to control mice (p<0.05). Conclusion: Garid-5 is safe in mice demonstrating no noticeable toxicity. Garid-5 exhibits a potent peripheral analgesic effect.