Aim of the study Aim of the study: The aim of our work intends to define of peripheral analgesic effect of the traditional drug Garidi 5 in experimental animal models. Objectives of the study: 1. To determinate the LD50 of traditional drug Garidi-5 2. To study of analgesic effect of Garidi-5 on experimental animal models Material and Methods: Mongolian traditional drug Garidi 5 was produced from the traditional drug manufacture of TMSTPCorporation of Mongolia. - The LD50 of Garidi-5 determined by Chan Chi (2005) - Analgesic effect was assessed by glacial acetic acid-induced writhing test (for peripheral action). All the animals used in the study were taken care of under ethical consideration, with approval from Ethical Committee Corporation and Minister of Health of Mongolia. Analgesia by peripheral action: The peripheral analgesic effect was tested by glacial acetic acid–induced writhing test in Albinomice (Wilkin et al,1961). Healthy mice of either sex weighing 20-30 g were fasted overnight and divided into three groups with six animals in each group. One hour after administration of drugs, induction of writhing was done in mice by giving intra peritoneal injection of acetic acid at a dose of 10 ml/kg body weight. The number of writhing responses were counted and recorded for 20 min. Traditional drug of Garidi 5 (20 mg/kg , 80 mg/kg, 200 mg/kg) was used as the test drug. Aspirin was taken as standard drug at a dose of 100 mg/kg p.o. (Ghosh, 2008) Results: Traditional drug Garidi-5 is LD50=2,28±0,15, it’s means that drug has low toxicity. Aqueous extract of Garidi 5 had significant peripheral analgesic effect as compared to control (p<0.05).