1.Opioid switching to oxycodone injection using simple conversion ratio
Tsuyoshi Miyahara ; Toshifumi Kosugi ; Ayumi Nita ; Sasagu Hamada ; Atsuko Hiura ; Naomi Mori ; Yuki Hachiya ; Naomi Hirakawa ; Hidetoshi Sato ; Hisashi Matsunaga
Palliative Care Research 2014;9(4):125-130
Purpose: The simple conversion ratio of 1:1:1/50 between oxycodone injection (OXJ), morphine injection and fentanyl injection is used at Saga-Ken Medical Centre Koseikan. However, there are no studies on the validity of the simple conversion ratio. Methods: A total of 18 patients with opioid switching to OXJ using the simple conversion ratio were reviewed in this investigation. We surveyed the change in the numeric rating scale (NRS) and adverse effects before and after opioid switching. Result: The average period needed to reach a stable dose of OXJ was 0.6 days. The reasons of opioid switching to OXJ were the uncontrolled cancer pain in 11 patients, the impossibility of oral administration in 6 patients, the drowsiness in 1 patient. The average NRS decreased from 3.3 to 1.1 in 11 patients with uncontrolled cancer pain (p=0.007). No obvious change in the NRS was observed in 6 patients with the impossibility of oral administration. In 18 patients, there was no significant difference in adverse effects before and after opioid switching. Conclusion: These results indicate that the simple conversion ratio could be safety for opioid switching between OXJ and other opioid in cancer pain treatment.
2.Studies on asymptomatic microhematuria observed in health care center of Obihiro Kosei hospital.
Jun YAMAGUCHI ; Yukie WAKAHARA ; Naomi KOIZUMI ; Masaki SHIOZAKI ; Hiroe TAMURA ; Yukie MARUKO ; Satoko III ; Hiroko KAWAI ; Takashi YOSHIKAWA ; Tsugio TERAI ; Osamu ISHIMARU ; Kaname AMEDA ; Kazushi HIRAKAWA ; Toshiaki GOTOU ; Shigeo SAKASHITA
Journal of the Japanese Association of Rural Medicine 1989;38(1):30-33
From January 1981 through December 1986, 27, 513 individuals consisting of 17, 918 males and 9, 595 females underwent health examinations at Health Care Center in Obihiro Kosei Hospital. 14.2% of healthy and asymptomatic men and 29.1% of healthy and asymptomatic women had microscopic hematuria (one or more RBCs per HPF).
To evaluate the clinical significance of microhematuria, about one third of patients with asymptomatic microhematuria who had undergone complete urological examination were reviewed.
Genitourinary neoplasms were found in 0.21%(8 bladder cancers, 2 prostatic cancers and 1 renal cell cancer). The incidence of cancers increases proportionate to increase in age, furthermore, lesions were found more commonly in men than in women. We could find no relationship between the degree of hematuria and the cause. The results suggest that patients with asymptomatic microhematuria should undergo urological examinations.