Purpose: The aim of this study was to clarify the current state and effectiveness of antibiotic use in our palliative care unit (PCU). Methods: Among the cancer patients hospitalized in our PCU between May 1, 2012 and April 30, 2013, the subjects of this study were treated with parenteral antibiotics for infections. All data were retrospectively collected from medical records. Results: Parenteral antibiotics were prescribed in 44.3% of all. The most common sites of infections were the respiratory tract (63.6%) and the urinary tract (18.2%). In 59.1% of the cases, the outcome of use of antibiotics was helpful, in 9.1% of cases there was no change, in 13.6% of cases it was unhelpful, and in 18.2% of cases it could not be assessed. The outcome of antibiotic use was supposed to be excellent for urinary tract infections, but defective for terminal cases near death. Conclusion: The use of antibiotics is common in PCU and the responsiveness of the antibiotics could be different among certain subgroups.