1.The treatment of intra-radioemboliza- tion with ~(32)P glass microspheres in hepatocellular carcinoma
Changyuan WEI ; Weiping YANG ; Jianlun LIU ; Nanwu YANG ; Jiansi CHEN ;
Chinese Journal of Current Advances in General Surgery 1998;0(01):-
Objective:To determine the therapeutic effects of hepatic radioembolization with phosphorus 32 glass microsphere( 32 P GMS) in the treatment of hepatocellular carcinoma(HCC).Methods:21 cases of HCC had received the hepatic radioembolization by 32 P GMS.Results:The blood flow in the hepatic artery of tumor area reduced remarkably,even nearly disappeared,the size of tumor was smaller after the hepatic artery administration with 32 P GMS.The survival rate of 6,12,and 18 months was 85.7%,61.9%,57.1% respectively.Conclusion:The Intraradioembolization is effective therapy for the advanced HCC.
2.Breast-conserving therapy for breast cancer and its prognosis
Jianshan HONG ; Jianrong YANG ; Chuangmin ZHANG ; Jianlun LIU ; Nanwu YANG ; Jiansi CHENG ; Huawei YANG
Chinese Journal of General Surgery 2001;0(09):-
Objective To explore the effect of breast-conserving therapy for breast cancer(BCT) and its prognosis. Methods The clinical data of 69 cases of BCT admitted from January 1992 to December 2003 were analyzed retrospectively. The cases included those who had BCT without radiotherapy and those who had BCT with adjuvant radiotherapy, chemotherapy and hormonal therapy. The patients were followed up for 12 to 140 months. Results The 3-year recurrence rate for patients without radiotherapy (11.54%) was higher than that for those with radiotherapy (3.03%) (P
3.Resection of segment VIII of liver after cryotherapy for hepatocarcinoma
Changyuan WEI ; Weiping YANG ; Jianlun LIU ; Jiansi CHEN ; Ting LI ; Nanwu YANG
Chinese Journal of General Surgery 2001;10(2):115-116
Objective To study the applicable value of resection of segment VIII after cryotherapy for hepatocarcinoma. Methods As for 8 patients with hepatocarcinoma in segment VIII, the turnor was dealt with cryotherapy before resected. Results All the tumors were resected smoothly after cryotherapy with less bleeding (mean 430ml), less time (mean 138min) and without severe complications or postoperative death in this series. Conclusions Resection of segment VIII after cryotherapy for hepatocarcinoma is proved safe and feasible, whitch can decrease blood loss, save time, reduce tissue injury, and decrease postoperative recurrence.
4.Resection of segment VIII of liver after cryotherapy for hepatocarcinoma
Changyuan WEI ; Weiping YANG ; Jianlun LIU ; Jiansi CHEN ; Ting LI ; Nanwu YANG
Chinese Journal of General Surgery 1993;0(02):-
Objective To study the applicable value of resection of segment VIII after cryotherapy for hepatocarcinoma. Methods As for 8 patients with hepatocarcinoma in segment VIII, the turnor was dealt with cryotherapy before resected. Results All the tumors were resected smoothly after cryotherapy with less bleeding (mean 430*!ml), less time (mean 138*!min) and without severe complications or postoperative death in this series. Conclusions Resection of segment VIII after cryotherapy for hepatocarcinoma is proved safe and feasible, whitch can decrease blood loss, save time, reduce tissue injury, and decrease postoperative recurrence.
5.The influence of progesteron on the changes of aquaporin-4 expression and blood-brain barrier permeability in rats after experimental contusion and laceration of brain
Yonghong DUAN ; Nanwu CHEN ; Dan WANG ; Yongmei YANG ; Yongshi LIAO ; Richu LIANG ; Yugao SHU
Journal of Chinese Physician 2009;11(12):1616-1619
Objective To discuss the mechanism of progesterone that soften brain water content in traumatic brain edema in rats. Methods The models of focal lobe contusion and laceration of brain were made on the male rats treated by the progesterone following injury. Immunohistochemical method was used to assess the expression of aquaporin-4 (AQP4). Evan's Blue method was used to detect the permeability of blood-brain barrier. Results Treated by the progesteron, the brain water content was significantly decreased, and the lower expression of AQP4 took place on astrocytes of the contusion and peri-contusion of the brain tissue after 24 h,72h ,and 120h . The content of EB was decreased at 6 h and 24 h post-injury. Conclusions Progesterone can soften the traumatic brain water content, which may be associated with the attenuation of AQP4 in frontal lobe contusion following traumatic brain injury ( TBI) and progesterone can protect the blood-brain barrier at early time after TBI.
6.THE DETECTION OF AFP mRNA IN PERIPHERAL BLOOD AND ITS CLINICAL SIGNIFICANCE
Ji CAO ; Liuliang QIN ; Jianjia SU ; Yuan LI ; Nanwu YANG ; Kechen BAN ; Chao OU ; Qinguo Mo
Cancer Research and Clinic 2000;0(06):-
Objective:To search the marker of micrometastatic hepatocellular carcinoma (HCC).Methods:Peripheral blood samples were obtained from 65 patients with hepatocellular carcinoma,21 non HCC malignant tumors,22 chronic hepatitis B or cirrhosis,and 21 normal healthy volunteers.To identify hepatocellular carcinoma cells in peripheral blood, liver specific alpha fetoprotein(AFP)mRNA was amplified from total RNA extracted from whole blood by nested reverse transcription polymerase chain reaction (Nested RT PCR).Results:AFP mRNA was not detected in the normal healthy volunteers and patients with non HCC malignant tumors.The presence of AFP mRNA in patients with HCC(44/65,67.7%)was higher than those with chronic hepatitis B or cirrhosis(2/22,9.1%, P