Gastric mucosa can be damaged by acute and chronic ethanol intake.Alcohol can cause acute and chronic gastric inflammation,such as mucosa hyperemia,edema,hemorrhage,erosion and ulcer formation.In this article we review the metabolism of ethanol,mechanism.The type of alcohol-induced gastric mucosal and therapy on gastric mucosal lesions induced by alcohol.

Alkylphenols(APs) , the second most widely used commercial non-ionic surfactants in the world, are the main degradated productions of alkylphenol ethoxylates (APEs). The structure, biodegradation, transportation and distribution in environment, environmental monitoring and management are reviewed in this paper. Many meaurement methods of APs show that APs possess estrogenoid effects, that mainly disturb endocrinal and reproductive system, especially, estrogen-dependent organs. APs are associated with decreased fertility, reproductive disfunction, inferbility and cancer formation. APs are able to bind estrogen receptors, to imitate or antagonize estrogen effects, to disturb formation and metabolism of endogenous hormones and receptors. APs are also able to change the structure, quantity and function of cells and to disturb the kinetics of cellcycle at cytological and molecular levels. The more work on epidemiological study and mechanism of APs are needed. Management program for controlling environmental pollution caused by APs is being speedily investigated and put into practice progressively. It is necessary to restrict the use of APEs.

Objective : To investigate the prevalence of dyslipidemia among overweight and obese primary and middle school students in Tongzhou District, so as to provide the evidence for the implementation of comprehensive health education and early interventions for overweight and obese students. Methods : The basic information, physical examinations and blood lipid testing results were collected from the primary and middle school students in Tongzhou District from 2015 to 2019 through the nutrition and health monitoring project among students in Tongzhou District. The epidemiological characteristics of overweight and obese students with dyslipidemia were descriptively analyzed. Results : Among the 1 483 primary and middle school students detected, the overall prevalence rates of overweight, obesity and dyslipidemia were 12.68% ( 188 students ), 20.43% ( 303 students ) and 20.57% ( 305 students ), respectively. The prevalence of dyslipidemia was higher in overweight and obese students ( 24.44% ) than in students with normal weight ( 18.65%, P<0.05 ), and the prevalence of dyslipidemia was higher in male overweight and obese students than in female overweight and obese students (29.00% vs. 18.92%, P<0.05), while higher prevalence of dyslipidemia was seen in middle school students than in primary school students ( 37.72% vs. 20.32%, P<0.05 ). In addition, the prevalence of dyslipidemia was higher in students with daily exercise of less than a hour than in students with daily exercise of a hour or longer ( 27.88% vs. 18.44%, P<0.05 ). Conclusions The prevalence of dyslipidemia is high among overweight and obese primary and middle school students in Tongzhou District. Health educations should be reinforced to male, middle school students with daily exercise of less than a hour.

Antihypertensive Agents ; therapeutic use ; Blood Pressure Determination ; Humans ; Hypertension ; physiopathology ; therapy

This paper is prepared to discuss the common issues in data management, such as building and training of data management team, standard operation procedure, document management, execution and communication, strategies to correct and prevent mistakes, and measures to improve the quality and efficiency of clinical trials and data management.
Clinical Trials as Topic ; Data Collection ; standards ; Information Storage and Retrieval ; standards

Objective To compare the clinical efficacy of intramedullary pin versus plate fixation for displaced mid-shaft clavicle fractures.Methods The databases,PubMed,CENTAL and CBM,were searched according to the standards of the Cochrane Collaboration for all the randomized controlled trials (RCTs) and clinical controlled trials (CCTs) comparing intramedullary pin with plate fixation for treatment of displaced mid-shaft clavicle fractures.In addition,hand search was also conducted in relevant journals.Time limit for search was from the beginning till December 2013.Trial quality was assessed using the modified Jadad scale and effective data were pooled for Meta analysis with software RevMan5.2.7,including wound infection,hospital stay,wound size,intraoperative blood loss,operation duration,implant irritation,implant problems,delayed union,malunion,nonunion,total complications and Constant scoring.Results Three RCTs and 7 CCTs with 697 patients were included in our study.The modified Jadad scoring showed fine quality of the 10 trials.Intramedullary fixation was significantly superior to plate fixation in wound size,intraoperative blood loss,operation duration,hospital stay,wound infection,and symptomatic hardware (P ＜ 0.05),but led to a significantly higher rate of implant problems (P ＜ 0.05).However,no significant differences were identified in total complication rate,delayed union,nonunion,malunion or Constant score (P ＞ 0.05).Conclusions The superiority of intramedullary fixation for displaced mid-shaft clavicle fracture lies in its advantages of minimally invasion,such as limited incision,less intraoperative bleeding,shorter operation time and hospital stay,less wound infection and implant irritation.Ahhough intramedullary fixation may lead to a higher rate of implant problems,it shows no significant differences from plate fixation in bone healing and functional recovery.

This paper is prepared to discuss the common issues in data management, such as building and training of data management team, standard operation procedure, document management, execution and communication, strategies to correct and prevent mistakes, and measures to improve the quality and efficiency of clinical trials and data management.

In recent years,along with social economic development and population aging,more and more fracture patients have received internal fixation and artificial joint replacement.Postoperative infection related to orthopedic implants is a catastrophic complication which imposes serious psychological,physiological and economic burdens on the patients.Therefore,it is necessary to be able to make an early diagnosis of the infection.However,diagnosis of implant-related infection is always a clinical problem for orthopedists.Currently,it is thought to be a valuable way to judge orthopedic implant infection by monitoring inflammatory cytokines.This article will offer an overview on the progress in research of diagnosis values of different inflammatory cytokines in postoperative infection related to orthopedic implants.

Absctact: Objective To discuss the correlation between the TCM syndromes and the clinical pathological features of central air way non-small cell lung cancer.MethodsTCM syndromes were determined through inquiry and physical examination for 109 cases of lung cancer patients. Remaining specimens after excision and routine pathological examination were under HE staining for pathological diagnosis and study. The correlation between the TCM syndromes and the clinical pathological features was analyzed.ResultsThe histological types of central airway non-small cell lung cancer comprised squamous cell carcinoma (69/109, 63.3%), salivary type carcinoma (27/109, 24.8%), adenocarcinoma (10/109, 9.2%) and other rare carcinomas (adenosquamous, 2/109, 1.8%; sarcomatoid carcinoma, 1/109, 0.9%). The clinical and pathological features showed that the elderly, male, smoking patients most commonly suffered from squamous cell carcinoma, while the young, female, non-smoking patients suffered from salivary type carcinoma most frequently. The distribution characteristics showed that the qi-yin deficiency syndrome was most common in squamous cell carcinoma and salivary type carcinoma, accounting for 41.4% (29/70) and 40.7% (11/27) respectively; qi-deficiency and phlegm-dampness syndrome was most common in adenocarcinoma, accounting for 50.0% (6/12). TCM syndrome types were closely related to sex, to smoking history, and to Karnofsky score respectively, with statistical significance (P<0.05,P<0.01). The qi-yin deficiency syndrome was common in male, smoking patients, while the qi-deficiency and phlegm-dampness syndrome and yin-deficiency and heat-toxin syndrome were common in female and non-smokers. The qin-yin deficiency syndrome was common in patients of Karnofsky score≥60, and qi-deficiency and phlegm-dampness syndrome was most frequently found in <60 scores group.Conclusion The histological types of central air way non-small cell lung cancer are related to age, gender and smoking history of patients. Patients with different ages, genders and smoking histories distribute differently in TCM syndrome.