Environmental Monitoring ; methods ; Environmental Pollutants ; analysis ; Microchip Analytical Procedures

It is high time to regulate the Chinese medical ethics review system and construct a supervision system of medical ethics review.According to the guideline of WHO,models of supervision system of medical ethic review in certain developed countries,and national conditions,this paper proposes several countermeasures including perfecting related legal system,constructing certification system of ethics review committee,and formulating integrated contents and procedure of supervision.

Objective To study the influence of microinflammation factors on the pregnancy outcome in gestational diabetes mellitus (GDM) patients.Methods Forty-eight GDM women with abnormal hsCRP and IL-6 concentration were selected as study group another 36 GDM women with normal concentration as control group.The difference of the two groups in common data and outcomes of pregnancy were retrospectively analyzed.Results There were significant difference in hypertensive disorders,prom,premature delivery,intra-uterine asphyxia,mega fetus,uterine-incision delivery and fetus hypoglycemia hypocalcemia between two groups (P ＜0.05).Conclusions Microinflammation factors have promote influence on the development and outcomes of GDM.Early diagnosis and impose intervention may have positive effect.

In this paper,our study on cultivating the quality and capabilities of the med-ical students in obstetrics and gynecology practice shows that quality education is the key to training talented students with lofty ethics,professional skills and humanities knowledge.

Retinal angiomatous proliferation(RAP) is a special type of age-related macular degeneration (AMD) with a pathological process of neovascularization.Different with several types of neovascular AMD,the new blood vessel in RAP is believed to originate from the inner retinal circulation.Because of inadequate knowledge,there still exist some limited understanding for this disease,such as its clinical diagnosis,therapy effectiveness and its poor prognosis.The newest interpretation about RAP was based on the findings of indocyanine green angiography(ICGA) and the first generation of optical coherence tomography (OCT) imaging system.The stage,histogenesis,histopathology,nature process,fundus findings,differentiating diagnosis and treatrnent of RAP were reviewed.

The treatments of infected bone defects are still a major clinical problem.In recent years,local delivery systems applied as anti-infection and bone repair material become a hot research topic.In this review,we discuss various influence factors such as osteoinductive growth factors,antibiotics,cartier material,extended release methods.We also introduce the recent progress in the development of local delivery system for the treatment of infected bone defects.

Objective:In order to observe the effect of avandia combined with insulin to treat patients with type 2 diabetes mellitus(T2DM). Methods:Seventy two patients whose blood sugar was not controlled well by hypodermic were randomized devided into two groups. Group A was administered insulin alone,Group B was administered insulin and avandia. Fast plasma glucose(FPG),blood sugar 2 hours following meals,HbA1c,plasm insulin and exogenetic insulin doses,etc. Results:FPG,blood sugar 2 hours following meals,HbA1c,plasm insulin level and exogenetic insulin dose were all decreased. Conclusion:Using avandia combined with insulin to treat patients with T2DM can lower blood sugar level of patients and improve insulin resistance. [

Objective:To observe the effects of Lipo PGE1 in Treatment of Diabetic nephropathy(DN).Methods:60 patients with clinical albuminuria were divided randomly into the treatment group and control group,receiving regular treatment.In addition,the cases of treatment group received treatment of PGE1 10?g daily for two weeks.The index of Scr and UAER were observed before and after treatment.Results:The Scr and UAER in treatment group were more decreased than those in control group.Conclusion:Lipo PGE1 is effective in treating Diabetic nephropathy.

Objective:To compare the safety and efficacy of premixed insulin aspart 30 (BIAsp30) with premixed human insulin 30R (BHI30)used in twice-daily injection regimen in patients with type 2 diabetes. Methods:Sixty-eight patients with inadequate glycemia control by oral drug were randomly divided into two groups using twice-daily insulin for 12 weeks comparison of BIAsp30 and BHI30. We compared HbA1c,seven-point blood glucose and frequency of hypoglycemia in two groups. Results:Blood glucose after breakfast and after dinner were significantly lower in BIAsp30 group than in BHI30 group(P0.05),meanwhile no serious hypoglycemia happened in BIAsp30 group. Conclusion:Post-prandial glycemia control was significantly improved,without increasing the risk of hypoglycemia,when people with type 2 diabetes were treated in twice-daily injection regimen with BIAsp30,as compared with BHI30.

Objective:To prepare amphotericin B(AmB)-polybutylcyanoacrylate(PBCA) nanoparticle and evaluate its characteristics,so as to screen for the optimal preparation technique.Methods: AmB was loaded to blank PBCA nanoparticles by incubation to prepare AmB-PBCA nanoparticles.The surface of the nanoparticles was modified with polysorbate 80.The AmB concentration of AmB-PBCA-NP solution was calculated with the standard curve of AmB at D_(405),and the stability of solution was assessed.The diameter distribution of the particles was determined with Coulter Laser granulometer.The colloid solution of AmB-PBCA-NP was centrifuged and the supernatant was harvested to determine the concentration of AmB.The encapsulation rate,drug loading rate,and in vitro drug release were measured.The optimized preparation recipe was screened using diameter,drug loading rate,and encapsulation rate of the particles as indices.Results: The prepared AmB-PBCA nanoparticle had a regular spherical or elliptic surface,with a mean diameter of(69.01?28.56) nm.The curve of standard AmB was linear within the range of 1.12-5.60 ?g/ml: D_(405)=0.163 4c+0.006 6(r=0.999 3).The average recovery of AmB-PBCA-NP was(99.93%,) showing the solution of AmB-PBCA-NP was stable within 12 h.The nanoparticles showed a sustained drug release in vitro within 24 h.The optimized recipe was: DextranT-70 stabilizer without sodium deoxycholate,with a mean encapsulation rate of 56.10% and a drug loading rate of 82%.Conclusion: The current method for preparing AmB-PBCA nanoparticles is simple and can meet the requirements of pharmaceutics.