Objectivc To compare the clinical effieacy of laparoscopic cholecystectomy(LC) combined with endoscopic sphincterotomy (EST) and LC in treatment of cholecystolithiasis associated with choledocholithiasls.Methods Seventy-six patients with cholecystolithiasis associated with choledocholithiasis were divided into observation group and control group by random digits table,38 cases in each group,and respectively received LC combined with EST and LC combined with choledocholithotomy and T drainage.Theoperative time,hospitalization time,blood loss and complications in the two groups were compared.Results The operative time and hospitalization time of observation group were(105.3±13.2)min and(11.3±3.2)d respectively,and which were significantly shorter than those in control group[(140.5±15.6)min,(14.2±4.6)d],the differences were statistically significant between the two groups(P<0.05).Both groups had no serious complications happened.Conclusion LC combined with EST in treatment of cholecystolithiasis associated with choledocholithiasis has advantages such as effective,litfle trauma,rapid recovecy and less comphcations,it is worthy of clinical application.