Objective To observe clinical effects of compound Muniziqi granules combined with vitamin A acid cream, and analyze its mechanism of action.Methods 76 cases of patients with chloasma treated in our hospital in March 2010 to February 2014 were selected.They were divided into two groups according to random number table method, 38 cases in each group.Observation group was given compound Muniziqi granules( three times per day,orally) combined with vitamin A acid cream(smear once respectively each morning and evening),control group was taken vitamin C 0.3 g and vitamin E 0.2 g ( three times per day, orally ) comined with vitamin A acid cream ( smear once respectively each morning and evening ) treatment.Observed clinical effects, scores of lesion area and color, detected serum estrogen level in both groups by radioimmunoassay. Results Compared with pre-treatment lesion area and color scores of observation group significantly reduced ( P<0.05 ).Compared with control group post-treatment, lesion area and color scores of observation group significantly reduced(P<0.05).Clinical effective rates of observation group and control group was 94.74%and 75.31%, respectively, the difference was significantly between two groups(P<0.05).Compared with pre-treatment, serum E2, FSH, LH levels of observation group were remarkably reduced(P<0.05).Compared with control group post-treatment, serum E2,FSH,LH levels of observation group significantly reduced(P<0.05).Conclusion The clinical effect of compound Muniziqi granules combined with vitamin A acid cream on chloasma is significant.Its mechanism may be relate to levels of estradiol, follicle-stimulating hormone and luteinizing hormone.