1.Research advance on the mechanism of congenital anomalies caused by folic acid deficiency.
Chinese Journal of Contemporary Pediatrics 2006;8(6):527-530
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
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genetics
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Carrier Proteins
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genetics
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Congenital Abnormalities
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etiology
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Folate Receptors, GPI-Anchored
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Folic Acid Deficiency
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complications
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etiology
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Homocysteine
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blood
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Humans
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Membrane Transport Proteins
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genetics
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Methylenetetrahydrofolate Reductase (NADPH2)
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genetics
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Receptors, Cell Surface
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genetics
2.A child with thrombus formation in a giant coronary aneurysm caused by Kawasaki disease.
Shu-qun WU ; Ping HUANG ; Na DAI
Chinese Journal of Pediatrics 2006;44(5):385-386
Child
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Coronary Aneurysm
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diagnostic imaging
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physiopathology
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Coronary Thrombosis
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diagnostic imaging
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physiopathology
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Coronary Vessels
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diagnostic imaging
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physiopathology
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Female
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Humans
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Mucocutaneous Lymph Node Syndrome
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complications
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diagnosis
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diagnostic imaging
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physiopathology
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Ultrasonography, Doppler
3.Competing endogenous RNA and tumor pathological mechanism
Shu ZHOU ; Na SHEN ; Fanjun CHENG
Journal of International Oncology 2017;44(2):115-117
Competing endogenous RNA (ceRNA) is a class of RNA which includes mRNA,pseudogenes,long non-coding RNA (lncRNA),circular RNA (circRNA).ceRNA weakens its inhibitory effect on mRNA translation through competitive binding with shared microRNA (miRNA).Many studies have confirmed that the disorder of ceRNA is closely related to the occur-ence of breast cancer,gastric cancer,lymphoma and other tumors.With the improvement of researches,ceRNA may be used as a tumor marker of clinical diagnosis and therapeutic target.
4.Design of Health Service Mode Based on Informatization Reengineering of Medical Process
Shu LI ; Na LIU ; Mingju WANG
Journal of Medical Informatics 2017;38(5):16-20
Based on the analysis of the existing medical service process,the paper takespatient centered as the ultimate objective,and transforms the health service process from the view of informatization including smart hospital,regional health and family health processes.The design includes the health service modes of smart hospital,family health and regional health sub-modules,and provides ideas for the achievement of wisdom medical in the future.
7.Analysis of the influence factors of central venlus catheters-related infections in postoperative patients with gastric carcinoma treated with parenteral nutrition
Yanxia TAO ; Yue ZHAO ; Na SHU ; Guiming YAN
Chinese Journal of Practical Nursing 2015;31(22):1662-1665
Objective To investigate the influence factors of central venous catheter related infections (CVC-RI) in postoperative patients with gastric carcinoma treated with parenteral nutrition,in order to provide scientific basis for prevention and treatment.Methods Using the retrospective study method,150 patients who treated with parenteral nutrition after operation of gastric carcinoma from December 2013 to March 2014 were selected.Information including age,sex,anamnesis,catheter indwelling time,infusion rate of nutrient solution,and so on were collected.Patients with central venous catheter related infections were set as infection group,patients without infection as the control group,and the group logistic regression analysis was used to analyze the collected data.Results 21 patients in infection group had CVC-RI,and the incidence was 14.00% (21/150),while 129 patients in control group had CVC-RI.Univariate analysis showed there was significant difference between infection group and control group in age,anamnesis,catheter indwelling time and infusion rate of nutrient solution (x2=17.126,5.447,12.795,7.973,P<0.05),however there was no significant difference in sex,health insurance,the success rate of catheterization and whether glutamine was in nutrient solution (P>0.05);the group logistic regression analysis showed that age (OR=15.927,95%CI 3.305-76.756,P<0.05)and catheter indwelling time (OR=3.511,95%CI 1.028-11.992,P<0.05) were independent risk factors for CVC-RI,however infusion rate of nutrient solution (OR=0.140,95%CI 0.033-0.597,P<0.05) was a protective factor.Conclusions For the postoperative patients with gastric carcinoma treated with parenteral nutrition,CVC-RI is closely related to age,catheter indwelling time and infusion rate of nutrient solution.So reducing catheter indwelling time,restoring the enteral nutrition under condition permission as so on as possible can reduce infection of elderly patients.
8.Glucocorticoid or androgen for autoimmune premature ovary failure in mice
Xiaobo SHI ; Na LI ; Can LIAO ; Qing SHU ; Fufan ZHU
Journal of Central South University(Medical Sciences) 2009;34(7):576-581
Objective Using mouse autoimmune premature ovary failure (POF) model to seek theoretical evidence for a possible clinical therapy of autoimmune POF with glucocorticoid (GC) or an-drogen. Methods After autoimmune POF was induced in 60 mice by Pzp3, the mice were randomly as-signed into 3 groups (n=20) : Two groups were treated with GC or androgen and the control group was treated with distilled water. We observed the changes in the sexual cycles of the mice, the serum level of AzpAb, infiltration of cells positively expressing CD45 in the ovary, and pathological alterations of the ovary. Results The sexual cycle of each therapy group was significantly different from that of the control group. The mean serum level of AzpAb of each therapy group was significantly lower than that of the con-trol group, and the mean serum level of AzpAb in the GC group was significantly higher than that of the androgen group. The percentage of growing follicles in the ovary of each therapy group was significantly higher than that of the control group. Ovaries infiltrated by cells positively expressing CD45 of each thera-py group were significantly fewer than those of the control group. Conclusion GC or androgen in mice with autoimmune POF could obviously ameliorate the pathogenetic conditions of the disorder, and both treatments have similar therapeutic efficacy.