ObjectiveTo investigate the influential factors on the deaf children's hearing and speech rehabilitation.Methods43 deaf children were involved in our study. They performed the hearing thresholds, hearing ability, speech ability and learning aptitude tests.ResultsGender and hearing aid mode didn't correlate with the children's hearing and speech performance (P>0.05). Hearing thresholds had significant influence on the hearing ability (P<0.05), and the speech ability had a strong correlation with the children's learning aptitude (P<0.05). The multiple regression analysis showed that the hearing ability was a significant predictor of speech ability (P<0.001).ConclusionGiving hearing compensation timely and effectively and grasping the critical period of language development to do rehabilitation training as soon as possible are very important to deaf children's rehabilitation of hearing and speech ability.

Transient receptor potential(TRP) superfamily includes seven subfamilies and TRP channels are regulated by a wide variety of physical and chemical factors. Recently, several members of the TRP channel family have been reported to be regulated by phosphatidylinositol 4,5-bisphosphate(PIP2). The regulation is complex and it can be activation or inhibition, involving multiple mechanisms and factors. This review summarizes the PIP2 regulation of several TRP channels of different superfamilies and the related pathophysiological significance.

Objective To investigate the distribution and susceptibility of carbapenem resistant citrobacter freundii for rational antimicrobial therapy.Methods The C.freumdii were collected between January 2011 and December 2014 from inpatients.The minimum inhibitory concentration (MIC) were detected by an automated analyzer (VITEK 2) to analyze the characteristic of tested bacteria.Results (1) Of the 21 strains of carbapenemresistant citrobacter freundii,95％ were collected from urine,among which most of the strains were isolated from the Department of Transplantology (66.7％) and Urology (19％);(2) Antimicrobials Susceptibility test showed that Citmbacter freund were highly resistant to Cephalosporins and relevant beta-lactamase inhibitors.Even carbapenem were highly resistant.Imipenem had a resistance rate of 90％ (95％ confidence interval:70 to 99),Meropenem 85.7％ (95％ confidence interval:64 to 97),The drug resistance rate to Amikacin was only 4.8％,followed by Nitrofuran toin (10.5％) and Fosfomycin (15％).Conclusions Carbapenem resistant citrobacter freundii,which often causes urinary tract infection in our hospital,was characterized by multi-drug resistant (MDR).Monitoring of the Citrobaeter freundii should be strengthened to control the prevalence of drug resistance.

Objective: To study the anti-inflammatory, analgesic and immunosuppressive action of Niuhuang Qianjin San (NQS). Methods: The anti-inflammatory action of NQS was studied by the methods of rat paw swelling and mouse ear swelling and the analgesic action by mouse body torsion method and K + subcutaneous penetration method in rats.Immunosuppressive effect was evaluated by peripheral T lymphocyte percentage, splenic lymphocyte transformation ratio, phagocytic function of intraperitoneal magocytes, the activity of delayed hypersensitivity, serum hemolysin level and the function of antibody-yielding cells in mice. Results: NQS could obviously alleviate inflammation, increase codeine's analgesic action and suppress immunity. The difference were significant (P

Objective: To study the anti-inflammatory, analgesic and immunosuppressive action of Niuhuang Qianjin San (NQS). M ethods: The anti-inflammatory action of NQS was studied by the methods of rat pa w swelling and mouse ear swelling and the analgesic action by mouse body torsion method and K+ subcutaneous penetration method in rats.Immunosuppressive effec t was evaluated by peripheral T lymphocyte percentage, splenic lymphocyte transfor mation ratio, phagocytic function of intraperitoneal magocytes, the activity of delayed hypersensitivity, serum hemolysin level and the function of antibody-yie lding cells in mice. Results: NQS could obviously alleviate inflammation, increa se codeine's analgesic action and suppress immunity. The difference were signif icant (P<0.01) as compared with normal saline contr ol group.Conclusion:NQS exerts certain anti-inflammatory,analagisic and immunosu ppressive action.

Objective To investigate the relationship between with or without non?alcoholic fatty liver disease(NAFLD) and diabetic retinopathy(DR) in type 2 diabetes mellitus(T2DM)?Methods Clinical and laboratorial data of 517 cases T2DM hospitalized patients were collected,and the patients were divided into two groups according to if the NAFLD was complicated or not?Group A was T2DM with NAFLD and group B was T2DM without NAFLD?The general information and the laboratorial checking results were Compared, then various index were used as the independent variable, DR was used as the dependent variable for Logistic regression analysis?Results (1)In the 517 cases of T2DM patients,the incorporative rate of the NAFLD was 65?7%(349/517)?(2)Compared with group B,the levels of body mass index(BMI),insulin resistance index (HOMA?IR),glutamyltransferase(GGT),alanine aminotransferase(ALT),aspartate aminotransferase(AST), triglyceride(TG),total cholesterol(TC),low?density lipoprotein cholesterol(LDL?C) and uric acid(UA) for group A were significantly increased, while the high?density lipoprotein cholesterol ( HDL?C ) level was significantly decreased?All the differences were statistically significant( P<0?05)?( 3) Logistic analysis showed that the duration of the extension,hypertension,the increasing level of NAFLD,LDL?C were the risk factors of DR?Even though excluded the influence of duration,high blood pressure and LDL?C level,NAFLD was still the risk factor for T2DM complicated by the DR( OR=2?176,95% CI ( 1?354,3?199) )?Conclusion NAFLD and DR are closely related, so early diagnosis and intervention of NAFLD may prevent the occurrence and development of DR.

Objective To explore the characteristic of SPECT/CT imaging of osteolytic lesions with increased bone metabolism and its correlation with CT manifestation. Methods Twenty?one cancer patients with bone metastases underwent 99 Tcm?MDP SPECT/CT imaging ( 13 males, 8 females; age: ( 60. 52 ± 6?85) years) were retrospectively studied. The imaging characteristic of the lesion with high uptake of 99Tcm?MDP was observed and the correlation between the lesion/background ( L/B ) ratio and CT manifestation were analyzed. One?way analysis of variance, two?sample t test and linear correlation analysis were used. Results A total of 111 lesions were found in 21 patients by 99 Tcm?MDP whole?body bone scan, and 125 le?sions were found by SPECT/CT imaging, including 111 lesions with increased bone metabolism and abnor?mal CT manifestation and 14 osteolytic lesions with decreased bone metabolism. In 111 lesions with in?creased bone metabolism, there were 23(20.72%) osteolytic lesions, 54 (48.65%) osteoblastic lesions and 34 (30.63%) mixed lesions. The L/B ratio of osteolytic lesions with increased bone metabolism (11.82± 6?61) was lower than that of osteoblastic lesions (20.03±13.24) and that of mixed lesions (25.42±19.51;F=6.00, P<0?05) . The CT value of osteolytic lesions with increased bone metabolism was higher than that of osteolytic lesions with decreased bone metabolism :(167.53±79.21) HU vs (88.63±49.16) HU; t=3?345, P<0.05. The L/B ratio of lesions with increased bone metabolism was positively correlated to CT val?ue(r=0.404, P<0?05). Conclusions A part of lesions with increased bone metabolism on SPECT/CT im?ages are osteolytic lesions. The L/B ratio of them is positively correlated to CT value. SPECT/CT imaging can reduce missed diagnosis and misdiagnosis.

BACKGROUND: Many animal and clinical studies have reported that the safe and effective usage of umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) transplantation for treatment of neurological genetic diseases.OBJECTIVE: To investigate the feasibility and effect of UCB-MSCs transplantation in the treatment of spinal muscular atrophy (SMA).METHODS: A child admitted at January 2010 had been confirmed as having SMA, and drug and rehabilitation therapies were invalid. Then, the child received UCB-MSCs transplantation via the first intravenous infusion and three times of subarachnoid injection, once a week, (4-6)×107 cells once and four times as a course. Neurological physical examination, biochemical test, muscle enzymes detection, FIM scoring and electromyography (EMG) examination were conducted. RESULTS AND CONCLUSION: Compared with prior to transplantation, the level of muscle enzymes decreased, FIM scores were increased from 68 to 93 points, EMG results showed that the motor units with re-contraction in each 10.0 ms were increased that the motor function was improved, the lower extremity muscle strength elevated, and the self-care ability was improved in the SMA child at 6 months after transplantation. During the 10-month follow-up, the child had no adverse effects. It is indicated that UCB-MSCs transplantation is effective to treat SMA, and the neurological function has a remarkable restoration.

Objective To explore the relationship between emotional intelligence and job performance by investigating the level of them in pediatric nurses,and to provide a basis for improving job performance and the implementation of“quality care.Methods 335 pediatric nurses were investigated by using emotional intelligence scale and job performance scale.And the result of the investigation was analyzed statistically.Results The average score of the emotional intelligence of the pediatric nurses were (3.63±0.52),the highest score was interpersonal latitude (3.87± 0.69),the lowest score was management of emotions latitude (3.25±0.90); titles,the form of post and degree of nurses had a certain influence on the emotional intelligence.The score of job performance was(3.65±0.75).By Pearson correlation analysis,the emotional intelligence score and job performance score were obtained a significant positive correlation,self-motivation latitude and job performance were the most related,the management of emotional latitude job performance was the lowest.Conclusions Nursing managers should take corresponding measures to improve nurses' emotional intelligence and job performance levels,and promote the implementation of quality care effectively.