1.Cytotoxicity and Structure Activity Relationship of Dammarane-Type Triterpenoids from the Bark of Aglaia elliptica against P-388 Murine Leukemia Cells.
Ace Tatang HIDAYAT ; Kindi FARABI ; Desi HARNETI ; Rani MAHARANI ; DARWATI ; NURLELASARI ; Tri MAYANTI ; Arlette Suzy SETIAWAN ; Unang SUPRATMAN ; Yoshihito SHIONO
Natural Product Sciences 2017;23(4):291-298
Six dammarane-type triterpenoids, dammar-24-en-3β-ol (1), 3β-epicabraleahydroxy lactone (2), (E)-25-hydroperoxydammar-23-en-3β,20-diol (3), dammar-24-en-3β,20-diol (4), 3β-acetyl-20S,24S-epoxy-25-hydroxydammarane (5), and 3β-epiocotillol (6) were isolated from the methanolic extract of the bark of Aglaia elliptica. The chemical structure were identified on the basis of spectroscopic evidence and by comparison with those spectra previously reported. Compounds 1 – 6 were isolated first time from this plant. Compounds 1 – 6, along with a known synthetic analog, cabraleone (7) were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds 3β-acetyl-20S,24S-epoxy-25-hydroxydammarane (5) showed strongest cytotoxic activity with IC₅₀ value of 8.02 ± 0.06 µM.
Aglaia*
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In Vitro Techniques
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Leukemia*
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Meliaceae
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Methanol
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Plants
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Structure-Activity Relationship*
2.Cytotoxic Constituents from the Stem Bark of Chisocheton pentandrus
Rurini RETNOWATI ; Hermin SULISTYARTI ; Nikmatus Zahro WAHIDAH ; Anisa Lailatusy SYARIFAH ; Suprianto SALAM ; Nurlelasari ; Agus SAFARI ; Desi HARNETI ; Mulyadi TANJUNG ; Ace Tatang HIDAYAT ; Rani MAHARANI ; Unang SUPRATMAN ; Yoshihito SHIONO
Natural Product Sciences 2021;27(1):18-27
Eight cytotoxic constituents, consisting of six triterpenoids, cabralealactone (1), cabraleadiol (2), prototiamin A (3), 23-desmethyllimocin B (5), melianodiol (7) and indicalilacol (8) along with one limonoid, neemfruitins A (4) and one protolimonoid, protoxylocarpin G (6), were isolated from the extract of n-hexane of the stembark of Chisocheton pentandrus. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant. Compounds 1 - 8 were evaluated for their cytotoxic effect against MCF-7 breast cancer lines in vitro.Among the isolated compounds, melianodiol (7) showed the strongest cytotoxic activity with IC 50 values of 16.8µM
3.Cytotoxic Constituents from the Stem Bark of Chisocheton pentandrus
Rurini RETNOWATI ; Hermin SULISTYARTI ; Nikmatus Zahro WAHIDAH ; Anisa Lailatusy SYARIFAH ; Suprianto SALAM ; Nurlelasari ; Agus SAFARI ; Desi HARNETI ; Mulyadi TANJUNG ; Ace Tatang HIDAYAT ; Rani MAHARANI ; Unang SUPRATMAN ; Yoshihito SHIONO
Natural Product Sciences 2021;27(1):18-27
Eight cytotoxic constituents, consisting of six triterpenoids, cabralealactone (1), cabraleadiol (2), prototiamin A (3), 23-desmethyllimocin B (5), melianodiol (7) and indicalilacol (8) along with one limonoid, neemfruitins A (4) and one protolimonoid, protoxylocarpin G (6), were isolated from the extract of n-hexane of the stembark of Chisocheton pentandrus. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant. Compounds 1 - 8 were evaluated for their cytotoxic effect against MCF-7 breast cancer lines in vitro.Among the isolated compounds, melianodiol (7) showed the strongest cytotoxic activity with IC 50 values of 16.8µM