A compalative study of maximal aerobic power (MAP) with special reference to age were carried out as a basic study for determing the optimal physical load for successful living in modern society or in future ages. 169 males who have a sedentary living style profoundly affected by the motorization, 10-69 years of age, in suburban district of Fukuoka City (JAPAN) and 54 males who have a natural living style, 16-55 years of age, in rural districts of Nepal were selected as subjects. Measurement of MAP was made indirectly following to the method of Margaria et al.. Each subject were given two different intensity step up and down exercises, and MAP was calculated from heart rates immediately after exercises and individual's estimated maximal heart rate. % Fat was estimated from skinfold thickness according to the method of Nagamine.
Statistically significant correlations were found both of Japanese group (r= -0.554, P<0.001) and Nepalese group (r=0.561, P<0.001), and each regression equation etween MAP (ml/kg/min) and Age (yr) were as follows :
MAP=-0.350 Age +52.121 in the case of Japanese group.
MAP=-0.446 Age +63.395 in the case of Nepalese group.
However, difference of the regression coefficient was not significant.
Mean MAP per kilogram of body weight or per kilogram of lean body mass of every Japanese age groups wese lower than those of Nepalese groups with coincidental age, respectively. Generally, it is said that the socio-economical condition of Nepal today is a similar to that of Japan in the Meiji era. Therefore, it may be considered that modernization or urbanization have lowerd the system of Japanese people.
According to the review of literatures concerning to the living style and MAP in a evolutional and comparative point of view, it may be considerd that human races have maintained the relatively high MAP like Nepalese group today. Therefore, it is said conclusionally that the maintenance of mean MAP like Nepalese group is desirable in modern society or in future ages to prevent the degeneration of functions attributing the new health problem of modern society.

Objective: To investigate frequency of adverse drug reactions (ADR) on HIGURD ®
, a switch OTC product of azelastine hydrochloride, in a three-year post-marketing surveillance study.
Methods: We conducted two surveys in this study a solicited survey with a questionnaire and a survey of spontaneous ADR reports.
Results: A total of 183 cases with 293 ADRs were reported in the solicited survey on 3,453 consumers and a total of 29 cases with 37 ADRs were reported from spontaneous sources.  No serious ADRs were reported.  Most frequently reported ADRs were somnolence, thirst, malaise, and dysgeusia, all of which are common on azelastine hydrochloride.  This study indicated that HIGURD ®
is well tolerated.
Conclusion: This study suggested that efficacy and safety of HIGURD ®
depend on how much consumers understand the contents of “Precautions for Use” section of package insert.  It is considered to be effective for safety assurance in an early post-marketing phase that pharmacists inform consumers about appropriate use of HIGURD ®
and ask for the occurrence of ADRs.