Abstract: Objective To investigate the prevalence and influencing factors of depressive symptoms among primary and middle school students in Xihu District, Hangzhou City, so as to provide insights into depression control among primary and middle school students. Methods: Students were sampled from two primary schools, two junior high schools, two ordinary high schools and one vocational high school in Xihu District using a stratified cluster random sampling method from September to November, 2021. Participants' demographics, diet, exercise, sleep and campus bullying were collected using questionnaire surveys. The depressive symptoms were evaluated using the Chinese version of the Center for Epidemiologic Studies-Depression Scale (CES-D), and factors affecting the depressive symptoms were identified among primary and middle school students using a multivariable logistic regression model. Results: A total of 1 518 students were investigated, including 518 primary school students (34.12%), 363 junior high school students (23.91%), 463 ordinary high school students (30.50%) and 174 vocational high school students (11.46%). Of all participants, there were 805 males (53.03%). The prevalence of depressive symptoms was 38.87% among the participants, and was 36.10%, 42.42%, 42.33% and 30.46% among primary school, junior high school, ordinary high school and vocational high school students, respectively. The multivariable logistic regression analysis showed that gender (OR=1.601, 95%CI: 1.289-1.989), type of school (junior high school, OR=1.299, 95%CI: 0.974-1.734; ordinary high school, OR=1.351, 95%CI: 1.025-1.780; vocational high school, OR=0.862, 95%CI: 0.585-1.272), frequency of fresh vegetable intake (less than once daily, OR=0.454, 95%CI: 0.304-0.679; once and more daily, OR=0.359, 95%CI: 0.235-0.548), duration spent on the internet (0.5 to 1 h daily, OR=1.447, 95%CI: 1.044-2.006; 1 h and longer daily, OR=1.456, 95%CI: 1.072-1.978), sufficient sleep (OR=0.525, 95%CI: 0.371-0.744), suffering from campus bullying (OR=1.992, 95%CI: 1.491-2.661) were associated with the development of depressive symptoms. Conclusions The prevalence of depressive symptoms is high among primary and middle school students in Xihu District. Gender, type of school, dietary behaviors, sleep duration and campus bullying are factors affecting the development of depressive symptoms.

Background and Aims:Severe and multiple complications significantly affect the survival of patients after pancreaticoduodenectomy(PD).Previous studies have primarily focused on improving anastomosis techniques to reduce postoperative fistulas,with limited research on anatomical approaches to decrease complications and improve patient outcomes.This article summarizes our team's experience in applying curettage and suction dissection method in PD and analyzes its safety and clinical efficacy. Methods:The clinical data from patients undergoing elective PD in the Department of Hepatobiliary Surgery of Inner Mongolia Medical University Hospital from January 2021 to June 2023 were retrospectively collected.Patients using the curettage and suction dissection method were designated as the observation group,while those using traditional anatomical techniques were served as the control group.The observation group utilized the Peng's multifunctional operational dissector(PMOD),whereas the control group used conventional electrotome and ultrasonic scalpel during operation.The main clinical variables between the two groups were compared,and factors affecting postoperative survival of patients were also analyzed. Results:A total of 169 patients were included,with 59 in the observation group and 110 in the control group.No significant differences in baseline characteristics were found between the groups(all P＞0.05).The observation group exhibited more nerve infiltration during surgery than the control group(64.41％vs.39.09％,P=0.002),but had significantly shorter operative time(236 min vs.330 min,P＜0.01).There were no significant differences in lymph node metastasis,blood loss,or vascular infiltration between the two groups(all P＞0.05).The incidence of postoperative pancreatic fistula was significantly lower in the observation group than that in the control group(16.9％vs.40.0％,P=0.002).No significant differences were noted between the groups in terms of reoperation rate within one month,postoperative hospitalization duration,bile leakage,bleeding,infection,delayed gastric emptying or survival(all P＞0.05).Multivariate Logistic regression analysis identified smoking,tumor nerve infiltration,and delayed gastric emptying as independent risk factors affecting survival(all P＜0.05). Conclusion:Using curettage and suction dissection method with PMOD in PD is safe and feasible.It is simpler,less invasive,and results in shorter operative time compared to traditional method,indirectly reducing postoperative complications.Its clinical efficacy is reliable,suggesting potential for broader application in clinical practice.

Onodera prognostic nutrition index (OPNI) is a simple and effective parameter. It is calculated by serum albumin level and peripheral blood lymphocyte count. Initially, OPNI is used to assess preoperative nutritional status and surgical risk. In recent years, researchers have found that OPNI is related to the prognosis of many tumors. Simple and accurate prognosis evaluation can help to select treatment methods for digestive system malignant tumors, determine the best pre-operative treatment time and operation time, and improve the survival rate of patients with diges-tive system malignant tumors. The authors review the related literatures at home and abroad, and summarize the research advances in the prognostic value of OPNI for malignant tumors of digestive systems.

Presently, nonalcoholic fatty liver disease has become the most common pathogenic factor of chronic liver disease worldwide that can lead to the occurrence of hepatocellular carcinoma (HCC). Lipid metabolism in cancer cells is closely related to tumorgenesis, invasion and metastasis, and thus acts as one of the hallmark of cancer cells. Lipolipomics is an important branch of metabolomics, which has been adapted recently in the study of HCC for analysis of the structure and function of lipid components by chromatography and mass spectrometry. Fatty acids, glycerides, glycerophospholipids, sphingolipids, and sterol are significantly different in HCC tissues or serum. Therefore, it contributes to the diagnosis, determination of prognosis, mechanistic study and targeted therapy of HCC.